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Alternate splicing of mouse fusin/CXC chemokine receptor-4: stromal cell-derived factor-1alpha is a ligand for both CXC chemokine receptor-4 isoforms

Autor: M Heesen, M A Berman, U E Höpken, N P Gerard, M E Dorf

Publikováno v: The Journal of Immunology. 158:3561-3564

Inspection of the intron splice junction of the mouse chemokine receptor fusin/CXC chemokine receptor R-4 (CXCR-4) revealed a potential in-frame alternative splice site in the region encoding the N-terminal ectodomain of the receptor. Both predicted

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::9c5e913c9fac3ae6e09812c2d7d0a711
https://doi.org/10.4049/jimmunol.158.8.3561

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Beta-chemokine TCA3 binds to and activates rat vascular smooth muscle cells

Autor: Y Luo, P A D'Amore, M E Dorf

Publikováno v: The Journal of Immunology. 157:2143-2148

The present study compares the activity of TCA3 with other beta-chemokines (macrophage inflammatory protein (MIP)-1 alpha, MIP-1 beta, and monocyte chemoattractant protein (MCP)-1) on rat vascular smooth muscle cells. TCA3, MIP-1 alpha, and MCP-1 (bu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::07dd70fa5567a3f30750b8f9166bb97f
https://doi.org/10.4049/jimmunol.157.5.2143

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Beta-chemokine TCA3 binds to mesangial cells and induces adhesion, chemotaxis, and proliferation

Autor: Y Luo, M E Dorf

Publikováno v: The Journal of Immunology. 156:742-748

Specific receptors for the beta-chemokine TCA3 have been identified on mouse monocyte/macrophage cell lines and on mouse mesangial cells. Using Scatchard plot analysis with 125I-labeled TCA3, a single high-affinity receptor (3-4 nM) was identified. C

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::1d33aca551b51fd85326411581d90e4c
https://doi.org/10.4049/jimmunol.156.2.742

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Biologic activities of the beta-chemokine TCA3 on neutrophils and macrophages

Autor: S Devi, J Laning, Y Luo, M E Dorf

Publikováno v: The Journal of Immunology. 154:5376-5383

Previous in vivo and in vitro studies demonstrated that the murine beta-chemokine TCA3 is a chemoattractant for monocytes/macrophages and neutrophils. The ability of TCA3 to activate these cell populations is now evaluated. Treatment with 10 to 20 nM

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::200a994c392195651d0f20f2a0441ad4
https://doi.org/10.4049/jimmunol.154.10.5376

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Transfection of TCR alpha-chains into suppressor and T helper cell hybridomas. Production of suppressor factors with predicted antigen specificity

Autor: V K Kuchroo, M C Byrne, E Greenfield, M J Whitters, E A Nalefsky, A Rao, M Collins, M E Dorf

Publikováno v: The Journal of Immunology. 154:5030-5038

Conditioned medium from Ag-specific suppressor T cell hybridomas contains soluble factors (TsF) that modulate immune responses in an Ag-specific manner. We previously generated a series of TCR-alpha- and TCR-beta- expression variants from a 4-hydroxy

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::3df1b68a8622fce05dccd4bf0afc5d08
https://doi.org/10.4049/jimmunol.154.10.5030

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T cell receptor alpha-chain defines the antigen specificity of antigen-specific suppressor factor but does not impart genetic restriction

Autor: R M O'Hara, M C Byrne, V K Kuchroo, A Nagelin, M J Whitters, S Jayaraman, S L Henderson, M E Dorf, M Collins

Publikováno v: The Journal of Immunology. 154:2075-2081

Previous studies utilizing NP (4-hydroxy, 3-nitrophenyl acetyl hapten)-specific, T suppressor hybridomas have indicated that expression of TCR-alpha, but not TCR-beta, mRNA is required for expression of Ag-specific suppressor factor bioactivity. Supp

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::8a6b176f412a428ca56571a1dcba8257
https://doi.org/10.4049/jimmunol.154.5.2075

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Biologic activities of the murine beta-chemokine TCA3

Autor: Y Luo, J Laning, S Devi, J Mak, T J Schall, M E Dorf

Publikováno v: The Journal of Immunology. 153:4616-4624

The murine beta-chemokine TCA3 was purified to homogeneity. The biologic activities of the purified glycoprotein were evaluated in vivo and in vitro. Mice injected i.p. with 1- to 100-ng purified rTCA3 exhibited a rapid influx of neutrophils and macr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::f7436528323f0dde4e629dd9c19fb079
https://doi.org/10.4049/jimmunol.153.10.4616

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Inhibition of in vivo tumor growth by the beta chemokine, TCA3

Autor: J Laning, H Kawasaki, E Tanaka, Y Luo, M E Dorf

Publikováno v: The Journal of Immunology. 153:4625-4635

TCA3 is a proinflammatory murine glycoprotein that shares structural features with cytokines of the beta chemokine family and is a chemoattractant for neutrophils and monocytes. To assess the in vivo functions of TCA3, the cDNA was expressed in two m

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::d2613ef7831c169b7791e0e926e5778d
https://doi.org/10.4049/jimmunol.153.10.4625

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Serologic analysis of the mouse beta chemokine JE/monocyte chemoattractant protein-1

Autor: Y Luo, J Laning, M Hayashi, P R Hancock, B Rollins, M E Dorf

Publikováno v: The Journal of Immunology. 153:3708-3716

Mouse monocyte chemoattractant protein-1 (MCP-1), previously termed JE, is a member of the beta chemokine gene family and a homologue of the human monocyte chemoattractant protein, MCP-1. Mouse rMCP-1 was used to immunize hamsters for the production

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::bc5518ffa4a91fb8e96d70b031f5f71b
https://doi.org/10.4049/jimmunol.153.8.3708

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