Zobrazeno 1 - 10
of 76
pro vyhledávání: '"M E Dolan"'
Autor:
Amy L. Stark, Wendy B. London, Navin Pinto, Sharon J. Diskin, Nancy J. Cox, M E Dolan, Susan L. Cohn, Hae Kyung Im, Nirav N. Antao, Eric R. Gamazon, Jamie Myers, Anuar Konkashbaev, John M. Maris, Susan M. Ludeman
Publikováno v:
Clinical pharmacology and therapeutics
High-risk neuroblastoma is an aggressive malignancy, with high rates of treatment failure. We evaluated genetic variants associated with in vitro sensitivity to two derivatives of cyclophosphamide for association with clinical response in a separate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::678982b07d2f849ae1809e26f0b8689d
http://europepmc.org/articles/PMC4029857
http://europepmc.org/articles/PMC4029857
Publikováno v:
Cancer Research. 73:P3-15
Chemotherapy-induced peripheral neuropathy is the major dose-limiting toxicity for several anti-cancer drugs including taxanes, platinating agents and microtubule inhibitors. In general, animal models have been used to study neuropathy. Our goals are
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::572868a9aa1e1f24f67d626f39e6710f
https://doi.org/10.1158/0008-5472.sabcs13-p3-15-10
https://doi.org/10.1158/0008-5472.sabcs13-p3-15-10
Autor:
Hitoshi Zembutsu, Eric P. Winer, Nancy J. Cox, M E Dolan, Claudia Wing, Mark J. Ratain, Michiaki Kubo, Chidiamara Njoku, Eric R. Gamazon, Dorothy Watson, Clifford A. Hudis, Yusuke Nakamura, Ivo D. Shterev, Kouros Owzar, Heather E. Wheeler, Chen Jiang, Deanna L. Kroetz, Robert Michael Baldwin, Lawrence N. Shulman, Uchenna O. Njiaju
Publikováno v:
Clinical Cancer Research. 19:491-499
Purpose: We sought to show the relevance of a lymphoblastoid cell line (LCL) model in the discovery of clinically relevant genetic variants affecting chemotherapeutic response by comparing LCL genome-wide association study (GWAS) results to clinical
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::52ab903ebd9ce84ee8e5b3bf7db1c03c
https://doi.org/10.1158/1078-0432.ccr-12-2618
https://doi.org/10.1158/1078-0432.ccr-12-2618
Autor:
Lidija K. Gorsic, Dana Ziliak, Heather E. Wheeler, Yujia Wen, M E Dolan, Rong Stephanie Huang
Publikováno v:
Pharmacogenetics and Genomics. 21:476-488
Aim To determine whether cellular apoptosis is a suitable phenotypic trait for pharmacogenomics studies by evaluating caspase 3/7-mediated activity in lymphoblastoid cell lines after treatment with six chemotherapeutic agents: 5′-deoxyfluorouridine
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f6c72cf1f645c25a1864a9192ad16818
https://doi.org/10.1097/fpc.0b013e3283481967
https://doi.org/10.1097/fpc.0b013e3283481967
Autor:
Eric R. Gamazon, Emily O. Kistner, Wei Zhang, Shiwei Duan, Rong Stephanie Huang, Nancy J. Cox, M E Dolan
Publikováno v:
Pharmacogenetics and Genomics. 20:269-273
We have developed Pharmacogenomics And Cell database (PACdb), a results database that makes available relationships between single nucleotide polymorphisms, gene expression, and cellular sensitivity to various drugs in cell-based models to help deter
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ad44228d3ea7d249d1002c3b5cda7ad9
https://doi.org/10.1097/fpc.0b013e328337b8d6
https://doi.org/10.1097/fpc.0b013e328337b8d6
Publikováno v:
Clinical Pharmacology & Therapeutics. 92:425-427
The use of cell-based models has emerged as a promising means to discover and validate pharmacologic phenotype-genotype relationships. The availability of large-scale genome studies in both human and model systems is now allowing us unprecedented opp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::035fd5046037d3f28f320f03d228d083
https://doi.org/10.1038/clpt.2012.115
https://doi.org/10.1038/clpt.2012.115
Publikováno v:
Bone Marrow Transplantation. 27:1201-1209
The ability to culture CD34+ stem cells, while maintaining their pluripotency, is essential for manipulations such as gene transfection for therapeutic trials. Human peripheral blood (PB) CD34+ cells (> or = 90% purity) were cultured for up to 4 days
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cbfe819582ce9bf7d15ff2bcaaceb9f7
https://doi.org/10.1038/sj.bmt.1703054
https://doi.org/10.1038/sj.bmt.1703054
Publikováno v:
Gene Therapy. 8:384-390
Introduction of foreign genes into human CD34(+) hematopoietic precursor cells offers a means to correct inborn errors or to protect human stem cells from chemotherapeutic damage. Electroporation is a non-chemical, nonviral, highly reproducible means
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6226e5221e90b71697ced3b968572e8e
https://doi.org/10.1038/sj.gt.3301393
https://doi.org/10.1038/sj.gt.3301393
Autor:
M E Dolan, Reginald B. Ewesuedo
Publikováno v:
Cancer Chemotherapy and Pharmacology. 46:150-155
Purpose: O6-Benzylguanine (BG) is a modulator of the DNA repair protein, O6-alkylguanine-DNA alkyltransferase (AGT). BG is converted in mice, rats and humans to an equally active, yet longer-lived metabolite, O6-benzyl-8-oxoguanine (8-oxo-BG) by CYP1
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5b67119d7a6b35fb0428861059744c41
https://doi.org/10.1007/s002800000121
https://doi.org/10.1007/s002800000121
Publikováno v:
Bioinformation
The International HapMap Project has recently made available genotypes and frequency data for phase 3 (NCBI build 36, dbSNPb129) of the HapMap providing an enriched genotype dataset for approximately 1.6 million single nucleotide polymorphisms (SNPs)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8b0badf1506bfe2b780816509d16b1e5
https://doi.org/10.6026/97320630003139
https://doi.org/10.6026/97320630003139