Zobrazeno 1 - 10
of 18
pro vyhledávání: '"M E Comly"'
Autor:
John A. Hanover, E J Blanchette-Mackie, S C Patel, M Sun, Mei Zhang, R Sundaram, M E Comly, Nancy K. Dwyer
Publikováno v:
Acta Paediatrica. 92:63-73
The cellular location of Niemann-Pick C2 protein (NPC2) in cultured human fibroblasts and Chinese hamster ovary cells was examined immunocytochemically and in living cells by expression of a functional red fluorescent protein chimeric analogue. Resul
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::84561242b5ec77b2114ea961d8e0c944
https://doi.org/10.1111/j.1651-2227.2003.tb00224.x
https://doi.org/10.1111/j.1651-2227.2003.tb00224.x
Autor:
Federico Martinez, John A. Hanover, M E Comly, Toshio Fujimoto, E. Joan Blanchette-Mackie, Pei Liu, Nancy K. Dwyer, Mei Zhang, Jerome F. Strauss, Lane K. Christenson
Publikováno v:
Journal of Biological Chemistry. 277:33300-33310
This study demonstrates that the steroidogenic acute regulatory protein-related lipid transfer (START) domain-containing protein, MLN64, participates in intracellular cholesterol trafficking. Analysis of the intracellular itinerary of MLN64 and MLN64
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7521b2919785d490626c3b4d6b85c168
https://doi.org/10.1074/jbc.m200003200
https://doi.org/10.1074/jbc.m200003200
Autor:
M E Comly, Joan Blanchette-Mackie, Silvia Santamarina-Fojo, Adele Cooney, Edward B. Neufeld, Nancy K. Dwyer, Mei Zhang, John A. Stonik, Alan T. Remaley, H. Bryan Brewer, Stephen J. Demosky
Publikováno v:
Journal of Biological Chemistry. 276:27584-27590
ABCA1, the ATP-binding cassette protein mutated in Tangier disease, mediates the efflux of excess cellular sterol to apoA-I and thereby the formation of high density lipoprotein. The intracellular localization and trafficking of ABCA1 was examined in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a2d2a8da163e4ae6eb149e2fd4ee569d
https://doi.org/10.1074/jbc.m103264200
https://doi.org/10.1074/jbc.m103264200
Autor:
M E Comly, John A. Hanover, Dona C. Love, Michael Krause, Peng Wang, Chithra N. Keembiyehetty, Michelle R. Bond, Salil Ghosh
Publikováno v:
The FASEB Journal. 26
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4a9bc187f1b4a90630b96564627e4507
https://doi.org/10.1096/fasebj.26.1_supplement.472.1
https://doi.org/10.1096/fasebj.26.1_supplement.472.1
Autor:
Raymond R. O'Neill, S Patel, M E Comly, Ehud Goldin, Adele Cooney, G Carstea, J D Butler, Joan Blanchette-Mackie, Calvin F. Roff, Marc C. Patterson
Publikováno v:
Journal of Biological Chemistry. 267:23797-23805
Fluorescent microscopic examination of fibroblasts cultured with low density lipoprotein (LDL) and progesterone (10 micrograms/ml) for 24 h revealed extensive filipin-cholesterol staining of perinuclear lysosomes. Levels of unesterified cholesterol w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::be4fa1d44c0e42e59b2f6d147f6e2348
https://doi.org/10.1016/s0021-9258(18)35908-8
https://doi.org/10.1016/s0021-9258(18)35908-8
Autor:
Dona C. Love, Edward B. Neufeld, Mei Zhang, Peter G. Pentchev, M E Comly, Adele Cooney, E. Joan Blanchette-Mackie, Nancy K. Dwyer, John A. Hanover
Niemann–Pick type C1 (NPC1) disease results from a defect in the NPC1 protein and is characterized by a pathological accumulation of cholesterol and glycolipids in endocytic organelles. We followed the biosynthesis and trafficking of NPC1 with the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c572bf754411bc1252c6990f00334a2b
https://europepmc.org/articles/PMC31858/
https://europepmc.org/articles/PMC31858/
Autor:
S Patel, Hidemichi Watari, John A. Hanover, E. Joan Blanchette-Mackie, Nancy K. Dwyer, Dona C. Love, Adele Cooney, Edward B. Neufeld, Jerome F. Strauss, Mei Zhang, M E Comly, Peter G. Pentchev
Publikováno v:
The Journal of biological chemistry. 276(5)
The Niemann-Pick C1 (NPC1) protein and endocytosed low density lipoprotein (LDL)-derived cholesterol were shown to enrich separate subsets of vesicles containing lysosomal associated membrane protein 2. Localization of Rab7 in the NPC1-containing ves
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4fa1a594215e343ce7c0d60fb108e6da
https://pubmed.ncbi.nlm.nih.gov/11032830
https://pubmed.ncbi.nlm.nih.gov/11032830
Autor:
J D, Butler, J, Blanchette-Mackie, E, Goldin, R R, O'Neill, G, Carstea, C F, Roff, M C, Patterson, S, Patel, M E, Comly, A, Cooney
Publikováno v:
The Journal of biological chemistry. 267(33)
Fluorescent microscopic examination of fibroblasts cultured with low density lipoprotein (LDL) and progesterone (10 micrograms/ml) for 24 h revealed extensive filipin-cholesterol staining of perinuclear lysosomes. Levels of unesterified cholesterol w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::87920567a5ca25cf81a0450640c35c62
https://pubmed.ncbi.nlm.nih.gov/1429719
https://pubmed.ncbi.nlm.nih.gov/1429719
Autor:
E J Blanchette-Mackie, Maria Tsokos, H. F. Merrick, M E Comly, S.P.F. Miller, Christine R. Kaneski, William D. Travis, Richard E. Gregg, Roscoe O. Brady, S. Mackie, M. R. Filling-Katz, Peter G. Pentchev, Robert S. Lebovics
Publikováno v:
Neurology. 42:1768-1768
We describe the unique clinical and histopathologic features of a child with biochemical and immunocytochemical features of Niemann-Pick disease type C (NPC). Clinically, she was found to have multiple xanthomas of the upper aerodigestive tract with
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0a3f0fc2a3b260148f5994a85aa06fd0
https://doi.org/10.1212/wnl.42.9.1768
https://doi.org/10.1212/wnl.42.9.1768
Autor:
T Tokoro, H Weintroub, J D Butler, M E Comly, M Filling-Katz, Marie T. Vanier, J Fink, Jane M. Quirk, Norman W. Barton, Howard S. Kruth
Publikováno v:
Proceedings of the National Academy of Sciences. 84:556-560
Fluorescence microscopic examination of filipin-stained cultured skin fibroblasts derived from two brothers with group D Niemann-Pick disease revealed abnormal storage of low density lipoprotein (LDL)-derived cholesterol. LDL stimulation of intracell
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::619a807b3241f038bc29c767bd7ca2df
https://doi.org/10.1073/pnas.84.2.556
https://doi.org/10.1073/pnas.84.2.556