Zobrazeno 1 - 2
of 2
pro vyhledávání: '"M E, Zoeckler"'
Autor:
P A, Trail, D, Willner, J, Knipe, A J, Henderson, S J, Lasch, M E, Zoeckler, M D, TrailSmith, T W, Doyle, H D, King, A M, Casazza, G R, Braslawsky, J, Brown, S J, Hofstead, R S, Greenfield, R A, Firestone, K, Mosure, K F, Kadow, M B, Yang, K E, Hellström, I, Hellström
Publikováno v:
Cancer research. 57(1)
The internalizing anti-Le(y) monoclonal antibody (MAb) BR64 was conjugated to the anticancer drug doxorubicin (DOX) using an acid-labile hydrazone bond to the DOX and either a disulfide or thioether bond to the MAb. The resulting disulfide (BR64-SS-D
Autor:
P A, Trail, D, Willner, S J, Lasch, A J, Henderson, R S, Greenfield, D, King, M E, Zoeckler, G R, Braslawsky
Publikováno v:
Cancer research. 52(20)
The anticarcinoma antibody BR64 was conjugated to a doxorubicin derivative, doxorubicin 13-[3-(2-pyridyldithio)propionyl]hydrazone, and the resulting conjugates (BR64-DOX) were evaluated for activity and immunological specificity in vitro and in huma