Výsledky vyhledávání

Outcomes of induction chemotherapy followed by concurrent chemoradiation for nasopharyngeal carcinoma

Autor: Ezra E.W. Cohen, Everett E. Vokes, Daniel J. Haraf, Daniel W. Golden, Sonali Rudra, Elizabeth A. Blair, Kerstin M. Stenson, Tobenna Nwizu, M. E. Witt

Publikováno v: Oral Oncology. 49:277-282

Summary Purpose Current standard therapy for nasopharyngeal carcinoma (NPC) is concurrent chemoradiation based on randomized data. However, limited randomized data exist to support the addition of induction chemotherapy (ICT). Methods 58 Patients wit

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::993a746763733907566dc30ce7141faf
https://doi.org/10.1016/j.oraloncology.2012.10.003

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A phase I dose escalation study of Ad GV.EGR.TNF.11D (TNFerade™ Biologic) with concurrent chemoradiotherapy in patients with recurrent head and neck cancer undergoing reirradiation

Autor: Mark W. Lingen, Joseph K. Salama, Victoria M. Villaflor, Everett E. Vokes, Daniel J. Haraf, Elizabeth A. Blair, Tanguy Y. Seiwert, Kerstin M. Stenson, Thomas E. Darga, Ezra E.W. Cohen, Ralph R. Weichselbaum, M. E. Witt

Publikováno v: Annals of Oncology. 24:769-776

Background AdGV.EGR.TNF.11D (TNFerade™ Biologic) is a replication-deficient adenoviral vector expressing human tumor necrosis factor alpha (TNF-α) under the control of the chemoradiation-inducible EGR-1 promoter. TNF-α has been shown to function

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5cdf74a91759b42771a8bfd5da00963f
https://doi.org/10.1093/annonc/mds523

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A randomized phase II study of 5-fluorouracil, hydroxyurea, and twice-daily radiotherapy compared with bevacizumab plus 5-fluorouracil, hydroxyurea, and twice-daily radiotherapy for intermediate-stage and T4N0-1 head and neck cancers

Autor: Everett E. Vokes, Joseph K. Salama, Daniel J. Haraf, Kerstin M. Stenson, M. E. Witt, T. Seiwert, R. Williams, R. Kunnavakkam, Elizabeth A. Blair, Ezra E.W. Cohen

Publikováno v: Annals of Oncology. 22:2304-2309

Introduction We conducted a randomized phase II study to evaluate the impact of adding bevacizumab (B) to 5-fluorouracil (5-FU), hydroxyurea (HU), and radiotherapy (FHX) for intermediate-stage and select T4 head and neck squamous cell cancers (HNSCC)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::70ecbace8e7203e133064b9ac02ae785
https://doi.org/10.1093/annonc/mdq736

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Induction chemotherapy and concurrent chemoradiotherapy for locoregionally advanced head and neck cancer: a multi-institutional phase II trial investigating three radiotherapy dose levels

Autor: Bruce Brockstein, E.O. Kistner, Everett E. Vokes, Fred R. Rosen, Ezra E.W. Cohen, Bharat B. Mittal, M. E. Witt, Athanassios Argiris, Kerstin M. Stenson, Joseph K. Salama, Daniel J. Haraf

Publikováno v: Annals of Oncology. 19:1787-1794

Background We hypothesized induction chemotherapy (IndCT) would improve distant control (DC) without compromising locoregional control (LRC) for locoregionally advanced head and neck cancer patients. Additionally, we systematically lowered radiothera

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::df24c974eb1ac3a3eea81abadbd47db1
https://doi.org/10.1093/annonc/mdn364

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Functional organ preservation with definitive chemoradiotherapy for T4 laryngeal squamous cell carcinoma

Autor: Joseph K. Salama, Kerstin M. Stenson, B.R. Knab, Ezra E.W. Cohen, Abhishek A. Solanki, Everett E. Vokes, Daniel J. Haraf, M. E. Witt

Publikováno v: Annals of Oncology. 19:1650-1654

Background Randomized trials established chemoradiotherapy as standard treatment for advanced laryngeal cancer. Patients with large-volume T4 disease (LVT4) were excluded from these trials. The purpose of this study was to report T4 laryngeal cancer

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::53144f222edabc9ba19345a6379295f7
https://doi.org/10.1093/annonc/mdn173

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Comparison of outcomes of locoregionally advanced oropharyngeal and non-oropharyngeal squamous cell carcinoma over two decades

Autor: Everett E. Vokes, Kerstin M. Stenson, Ezra E.W. Cohen, Tanguy Y. Seiwert, Daniel J. Haraf, Charles Muller, Lauren C. Das, Theodore Karrison, Elizabeth A. Blair, M. E. Witt

Publikováno v: Annals of oncology : official journal of the European Society for Medical Oncology. 26(1)

Background Human papillomavirus (HPV) has emerged as a causative agent and positive prognostic factor for oropharyngeal (OP) head and neck squamous cell cancer (HNSCC). This prompts inquiry into whether therapy improvements or increasing incidence of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a1e6110ceac603f5e3377e300c04350b
https://pubmed.ncbi.nlm.nih.gov/25361984

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A phase I–II study of concomitant chemoradiotherapy with paclitaxel (one-hour infusion), 5-fluorouracil and hydroxyurea with granulocyte colony stimulating factor support for patients with poor prognosis head and neck cancer

Autor: Laura Sulzen, Daniel J. Haraf, Everett E. Vokes, R. W. Weichselbaum, M. E. Witt, Kerstin M. Stenson, Bruce Brockstein

Publikováno v: Annals of Oncology. 11:721-728

Summary Background Concomitant chemoradiotherapy is an effective treatment modality for advanced head and neck cancer, but improved regimens are needed. We sought to define the toxicities, recommended phase II dose, and outcome of a combination chemo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7c9a1f252129b65ee333da1b65132433
https://doi.org/10.1023/a:1008324131519

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Final Results of a Randomized Phase 2 Trial Investigating the Addition of Cetuximab to Induction Chemotherapy and Accelerated or Hyperfractionated Chemoradiation Therapy for Locoregionally Advanced Head and Neck Cancer: HPV-negative Subset Analysis

Autor: Everett E. Vokes, Daniel J. Haraf, M. E. Witt, Tanguy Y. Seiwert, Victoria M. Villaflor, Allison Dekker, Mark W. Lingen, Elizabeth A. Blair, J.M. Melotek, Ezra E.W. Cohen, Masha Kocherginsky, Ryan J. Brisson

Publikováno v: International Journal of Radiation Oncology*Biology*Physics. 94:867

detection of recurrence were abstracted. Patients either received definitive RT alone (nZ38, 15.4%) or concurrent systemic therapy and RT (nZ209, 84.6%). Outcomes, including local control (LC), regional control (RC), locoregional control (LRC), freed

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::650885bd51ddcdd80f3d39a608d554c4
https://doi.org/10.1016/j.ijrobp.2015.12.029

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