Zobrazeno 1 - 10 of 84 pro vyhledávání: '"M E, Weksler"'
1
Cellular Basis of B Cell Clonal Populations in Old Mice
Autor: J, LeMaoult, J S, Manavalan, R, Dyall, P, Szabo, J, Nikolic-Zugic, M E, Weksler
Publikováno v: The Journal of Immunology. 162:6384-6391
Previous studies from this laboratory have shown that >85% of old mice have stable B cell clonal populations detectable by Ig heavy chain complementary-determining region 3 mRNA size analysis and confirmed by sequence analysis. B cells from the same
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::79cf904b509911c12b2c09321c734b9a
https://doi.org/10.4049/jimmunol.162.11.6384
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2
Clonal expansions of B lymphocytes in old mice
Autor: J LeMaoult, S Delassus, R Dyall, J Nikolić-Zugić, P Kourilsky, M E Weksler
Publikováno v: The Journal of Immunology. 159:3866-3874
The effect of age on the diversity of the murine Ig heavy chain repertoire has been studied in unimmunized C57BL/6 mice. We examined the heterogeneity of complementarity-determining region 3 (CDR3) sizes of Ig mRNA of the IgM and IgG isotypes using t
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::5199101177cb8b9c12a86cb2d3f96529
https://doi.org/10.4049/jimmunol.159.8.3866
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3
Expanded CD4+ and CD8+ T cell clones in elderly humans
Autor: R Schwab, P Szabo, J S Manavalan, M E Weksler, D N Posnett, C Pannetier, P Kourilsky, J Even
Publikováno v: The Journal of Immunology. 158:4493-4499
The diversity of the human TCR repertoire in aging has been studied by examining the profiles of complementarity-determining region 3 (CDR3) sizes expressed by the BV families. The TCRBV CDR3 profile, which shows size heterogeneity in young adult hum
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::ca8c26b38162bfcd339ccd78f0139822
https://doi.org/10.4049/jimmunol.158.9.4493
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4
Decreased steady state c-myc mRNA in activated T cell cultures from old humans is caused by a smaller proportion of T cells that transcribe the c-myc gene
Autor: D A Gamble, R Schwab, M E Weksler, P Szabo
Publikováno v: The Journal of Immunology. 144:3569-3573
The proliferative response of T cells is known to decrease with age of the T cell donor. We now report that this proliferative defect affects both major subsets (CD4+, CD8- and CD4-, CD8+) of peripheral T cells from old humans. Furthermore, this prol
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::d3e1ebe51a59095b511a31b629243aab
https://doi.org/10.4049/jimmunol.144.9.3569
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5
Abnormal T-cell repertoire is consistent with immune process underlying the pathogenesis of paroxysmal nocturnal hemoglobinuria
Autor: A, Karadimitris, J S, Manavalan, H T, Thaler, R, Notaro, D J, Araten, K, Nafa, I A, Roberts, M E, Weksler, L, Luzzatto
Publikováno v: Blood. 96(7)
Paroxysmal nocturnal hemoglobinuria (PNH) is an acquired clonal disorder of the hematopoietic stem cell (HSC). Somatic mutations in the PIG-A gene result in the deficiency of several glycosylphosphatidylinositol-linked proteins from the surface of bl
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::a2baf41c310cbd1d24b7b7f3c711f33c
https://pubmed.ncbi.nlm.nih.gov/11001919
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6
The effect of age on the B-cell repertoire
Autor: M E, Weksler, P, Szabo
Publikováno v: Journal of clinical immunology. 20(4)
The antibody repertoire changes with age. This change reflects, in part, the age-associated impairment in the production of a diverse population of naive B cells in the bone marrow and, in part, by the decreased diversification of B cells in the germ
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::03790e99ce1cb76e7c8ac3bcf99020fa
https://pubmed.ncbi.nlm.nih.gov/10939711
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7
Brain aging and memory: new findings help differentiate forgetfulness and dementia
Autor: M, D'Esposito, M E, Weksler
Publikováno v: Geriatrics. 55(6)
Geriatrics is pleased to highlight the clinical implications of research topics supported by the American Federation for Aging Research (AFAR). AFAR is a leading private organization supporting research on the aging process and diseases of older popu
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::911d6cb47a37eccf1ddfa0add96de673
https://pubmed.ncbi.nlm.nih.gov/10872346
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8
Failure of rearranged TCR transgenes to prevent age-associated thymic involution
Autor: H D, Lacorazza, J A, Guevara Patiño, M E, Weksler, D, Radu, J, Nikolić-Zugić
Publikováno v: Journal of immunology (Baltimore, Md. : 1950). 163(8)
After puberty, the thymus undergoes a dramatic loss in volume, in weight and in the number of thymocytes, a phenomenon termed age-associated thymic involution. Recently, it was reported that age-associated thymic involution did not occur in mice expr
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::5bdf77c3bd6a1479cd14504db769c0e4
https://pubmed.ncbi.nlm.nih.gov/10510364
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10
Stability of natural self-reactive antibody repertoires during aging
Autor: S, Lacroix-Desmazes, L, Mouthon, S V, Kaveri, M D, Kazatchkine, M E, Weksler
Publikováno v: Journal of clinical immunology. 19(1)
We have used a quantitative immunoblotting technique to analyze the repertoires of self-reactive antibodies in serum samples obtained from the same five healthy adults over a 25-year interval. The average age of the donors was 43 years at the time of
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::3bc5a7b3df3710eec790252057f0bbb1
https://pubmed.ncbi.nlm.nih.gov/10080102
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