Zobrazeno 1 - 5
of 5
pro vyhledávání: '"M E, Voss"'
Autor:
P H, Carter, P A, Scherle, J K, Muckelbauer, M E, Voss, R Q, Liu, L A, Thompson, A J, Tebben, K A, Solomon, Y C, Lo, Z, Li, P, Strzemienski, G, Yang, N, Falahatpisheh, M, Xu, Z, Wu, N A, Farrow, K, Ramnarayan, J, Wang, D, Rideout, V, Yalamoori, P, Domaille, D J, Underwood, J M, Trzaskos, S M, Friedman, R C, Newton, C P, Decicco, J A, Muckelbauer
Publikováno v:
Proceedings of the National Academy of Sciences. 98:11879-11884
The binding of tumor necrosis factor alpha (TNF-α) to the type-1 TNF receptor (TNFRc1) plays an important role in inflammation. Despite the clinical success of biologics (antibodies, soluble receptors) for treating TNF-based autoimmune conditions, n
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f9a3908e9a1c37930ac42fa8b42d12d9
https://doi.org/10.1073/pnas.211178398
https://doi.org/10.1073/pnas.211178398
Publikováno v:
Journal of Biological Chemistry. 269:15814-15818
Glucokinase regulates insulin secretion by controlling the rate of glucose phosphorylation. In this report we utilize islets transgenic for high affinity yeast hexokinase to examine the role of glucose phosphorylation on other beta cell functions. No
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d673b6a6c93f869649580e08671db332
https://doi.org/10.1016/s0021-9258(17)40753-8
https://doi.org/10.1016/s0021-9258(17)40753-8
Autor:
Chu-Biao Xue, John Roderick, Ronald L. Magolda, Carl P. Decicco, Jingwu Duan, Bruce D. Jaffee, Rui-Qin Liu, Robert C. Newton, Karl D. Hardman, David D. Christ, Irina Cipora Jacobson, W F DeGradodagger, Lihua Chen, Ruth R. Wexler, Li Wang, James M. Trzaskos, David J. Nelson, Dayton T. Meyer, Maryanne B. Covington, Robert A. Copeland, Xiaohua He, Ronald L. Corbett, K Kennedy, Christopher A. Teleha, Robert J. Cherney, M E Voss
Publikováno v:
Journal of medicinal chemistry. 44(16)
To search for TNF-alpha (tumor necrosis factor alpha) converting enzyme (TACE) inhibitors, we designed a new class of macrocyclic hydroxamic acids by linking the P1 and P2' residues of acyclic anti-succinate-based hydroxamic acids. A variety of resid
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::46ba7c5bfa58c64292cf74f355e0915a
https://pubmed.ncbi.nlm.nih.gov/11472217
https://pubmed.ncbi.nlm.nih.gov/11472217
Autor:
J S, Kerr, R S, Wexler, S A, Mousa, C S, Robinson, E J, Wexler, S, Mohamed, M E, Voss, J J, Devenny, P M, Czerniak, A, Gudzelak, A M, Slee
Publikováno v:
Anticancer research. 19(2A)
Recent evidence supports the involvement of integrins in angiogenesis: blockade of alpha v beta 3 and alpha v beta 5 integrins disrupts angiogenesis leading to decreased blood vessel formation and hence decreased tumor growth. We hypothesized that av
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::421ff01934e5f46d1873649960cf58fd
https://pubmed.ncbi.nlm.nih.gov/10368639
https://pubmed.ncbi.nlm.nih.gov/10368639
Publikováno v:
Drug design and discovery. 12(4)
A novel series of cognition enhancers was designed based on molecular modeling and X-ray structure analysis of EXP-9121 (2). This new series features a spirocyclic ring system that constrains the side chain substituents into the orientation seen in t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::d021797406405f6d74cc7bb710b821e6
https://pubmed.ncbi.nlm.nih.gov/9040989
https://pubmed.ncbi.nlm.nih.gov/9040989