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Changes in phosphate metabolism in thymoma cells suggest mechanisms for resistance to dexamethasone-induced apoptosis. A 31P NMR spectroscopic study of cell extracts

Autor: N W, Lutz, M E, Tome, N R, Aiken, M M, Briehl

Publikováno v: NMR in biomedicine. 15(5)

Treatment of the mouse thymoma-derived WEHI7.2 cell line with dexamethasone, a synthetic glucocorticoid, causes the cells to undergo apoptosis. Previous studies have shown that WEHI7.2 cell variants with an increased antioxidant defense exhibit incre

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::95e0bf9bf73631aff853f501bf15d581
https://pubmed.ncbi.nlm.nih.gov/12203227

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Catalase-overexpressing thymocytes are resistant to glucocorticoid-induced apoptosis and exhibit increased net tumor growth

Autor: M E, Tome, A F, Baker, G, Powis, C M, Payne, M M, Briehl

Publikováno v: Cancer research. 61(6)

Glucocorticoids are used for the treatment of lymphoid neoplasms, taking advantage of the well-known ability of these compounds to cause apoptosis in lymphoid tissues. Previously, we have shown that dexamethasone, a synthetic glucocorticoid, causes a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::f985cda1ef9dc2e94c66494941b1f8a1
https://pubmed.ncbi.nlm.nih.gov/11289160

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Thymocytes selected for resistance to hydrogen peroxide show altered antioxidant enzyme profiles and resistance to dexamethasone-induced apoptosis

Autor: Margaret M. Briehl, M E Tome

Publikováno v: Cell death and differentiation. 8(9)

Treatment of WEHI7.2 cells, a mouse thymoma-derived cell line, with dexamethasone, a synthetic glucocorticoid, causes the cells to undergo apoptosis. Previous work has shown that treatment of WEHI7.2 cells with dexamethasone results in a downregulati

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6b61f9f7653c2dbad9d9e4ca42c5ee77
https://pubmed.ncbi.nlm.nih.gov/11526450

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Hypusine biosynthesis in protein and its biological consequences

Autor: R J, Murphey, M E, Tome, E W, Gerner

Publikováno v: Advances in experimental medicine and biology. 250

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::bf76ee480d0e9da1f5e8c774ba7c7ed0
https://pubmed.ncbi.nlm.nih.gov/3151230

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Inhibition of ionizing radiation recovery processes in polyamine-depleted Chinese hamster cells

Autor: E W, Gerner, M E, Tome, S E, Fry, G T, Bowden

Publikováno v: Cancer research. 48(17)

Polyamines are involved in many cellular processes, including DNA structure and function. Since DNA, or some DNA-containing structure, is known to be the target for cell killing induced by ionizing radiation and a number of chemotherapeutic agents, w

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::268ae4be82530a919dc811ff8af786dc
https://pubmed.ncbi.nlm.nih.gov/3136915

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