Výsledky vyhledávání - "M E, Pierson"

Analysis of the active conformation of angiotensin II: a comparison of AII and non-peptide AII antagonists

Autor: M E, Pierson, R J, Freer

Publikováno v: Peptide research. 5(2)

Several molecular models of angiotensin II (AII) were constructed using information derived primarily from conformationally constrained AII analogues. In order to refine the original models, AII was compared using computer-aided molecular graphics wi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::2a018ad299dc78fdfb48fc3fe99c5e89
https://pubmed.ncbi.nlm.nih.gov/1581636

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Stimulus properties of arylpiperazines: NAN-190, a potential 5-HT1A serotonin antagonist

Autor: Milt Titeler, J. L. Herndon, Richard A. Glennon, M E Pierson, Robert A. Lyon, B. Misenheimer, Noreen Naiman

Publikováno v: Drug Development Research. 16:335-343

Arylpiperazines have been demonstrated to bind both at 5-HT1A and 5-HT1B serotonin receptors. In an attempt to design novel 5-HT1A agonists and antagonists, based on an arylpiperazine nucleus, we investigated the stimulus properties of a series of su

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::7b2965f16c21b3441c2f5a2fbddc061c
https://doi.org/10.1002/ddr.430160227

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N-(phthalimidoalkyl) derivatives of serotonergic agents: a common interaction at 5-HT1A serotonin binding sites?

Autor: Abd M. Ismaiel, Noreen Naiman, Richard A. Glennon, J D Smith, Milt Titeler, Robert A. Lyon, M E Pierson

Publikováno v: Journal of Medicinal Chemistry. 32:1921-1926

Several classes of agents are known to bind at central 5-HT1A serotonin sites In order to challenge the hypothesis that these agents bind in a relatively similar manner (i.e., share common aryl and terminal amine sites), we prepared N-(phthalimidobut

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::40fcc67c6102dad3bcd97bff38c55553
https://doi.org/10.1021/jm00128a039

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Design and synthesis of propranolol analogs as serotonergic agents

Autor: S B Schulman, Robert A. Lyon, Milt Titeler, Richard A. Glennon, P Kowalski, M E Pierson

Publikováno v: Journal of Medicinal Chemistry. 32:859-863

Serotonin (5-HT) binds with nearly identical affinity at the various central 5-HT binding sites. Few agents bind with selectivity for 5-HT1A sites. The beta-adrenergic antagonist propranolol binds stereoselectively both at 5-HT1A and 5-HT1B sites (wi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aeae81b74052385101bcd1c4ab8a0ab0
https://doi.org/10.1021/jm00124a021

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