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Induction of apoptosis in 9-nitrocamptothecin-treated DU145 human prostate carcinoma cells correlates with de novo synthesis of CD95 and CD95 ligand and down-regulation of c-FLIP(short)

Autor: D, Chatterjee, I, Schmitz, A, Krueger, K, Yeung, S, Kirchhoff, P H, Krammer, M E, Peter, J H, Wyche, P, Pantazis

Publikováno v: Cancer research. 61(19)

Stimulation of CD95 leads to oligomerization of this receptor and the recruitment of the Fas-associated death domain (FADD) and procaspase-8 to form the death-inducing signaling complex (DISC). Subsequent proteolytic activation of caspase-8 at the DI

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::b1631051dd58b5eac3d890f8289cdbc4
https://pubmed.ncbi.nlm.nih.gov/11585748

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Selective up-regulation of phosphatidylinositol 3'-kinase activity in Th2 cells inhibits caspase-8 cleavage at the death-inducing complex: a mechanism for Th2 resistance from Fas-mediated apoptosis

Autor: A S, Varadhachary, M E, Peter, S N, Perdow, P H, Krammer, P, Salgame

Publikováno v: Journal of immunology (Baltimore, Md. : 1950). 163(9)

In this study the mechanism of differential sensitivity of CD3-activated Th1- and Th2-type cells to Fas-mediated apoptosis was explored. We show that the Fas-associated death domain protein (FADD)/caspase-8 pathway is differentially regulated by CD3

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::c75e0bab6436783f2e5506faf101afeb
https://pubmed.ncbi.nlm.nih.gov/10528176

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Biochemical characterization of Caenorhabditis elegans UBC-1: self-association and auto-ubiquitination of a RAD6-like ubiquitin-conjugating enzyme in vitro

Autor: M. E. Peter Candido, S. David Leggett

Publikováno v: The Biochemical journal. 327

The Caenorhabditis elegans ubiquitin-conjugating enzyme UBC-1 is distinct from other RAD6 homologues in possessing a C-terminal tail 40 amino acid residues long [Leggett, Jones and Candido (1995) DNA Cell Biol. 14, 883-891]. Such extensions from the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9265e8694bf5bdcc329cac990a2056f2
https://pubmed.ncbi.nlm.nih.gov/9359401

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CD95-Associating Signaling Molecules

Autor: M. E. Peter

Publikováno v: Symposium in Immunology VI ISBN: 9783540617556

In recent years apoptosis has attracted more and more attention. In immunology it has become especially popular since it plays an important role in the development and maturation of normal T and B lymphocytes and in lymphoid malignancies. In the norm

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::5703c712b44f7800d4a6859c0d83ee5e
https://doi.org/10.1007/978-3-642-60562-8_5

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CD95 (APO-1/Fas)-associating signalling proteins

Autor: M E, Peter, F C, Kischkel, S, Hellbardt, A M, Chinnaiyan, P H, Krammer, V M, Dixit

Publikováno v: Cell death and differentiation. 3(2)

The CD95 (APO-1/Fas) receptor has attracted great interest in recent years because it transduces an apoptotic signal in a variety of different tissues. CD95 belongs to the NGF/TNF-receptor superfamily, members of which need to be trimerized by specif

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::1931ac0c90dbca761e263e72aeaa53da
https://pubmed.ncbi.nlm.nih.gov/17180078

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