Zobrazeno 1 - 10
of 16
pro vyhledávání: '"M E, Marongiu"'
Autor:
Ettore Novellino, M. E. Marongiu, P. La Colla, Marco Artico, Roberta Costi, Silvio Massa, Giovanni Greco, Enzo Tramontano, R. Di Santo, A. De Montis
Publikováno v:
Journal of Medicinal Chemistry. 41:3948-3960
Various cinnammoyl-based structures were synthesized and tested in enzyme assays as inhibitors of the HIV-1 integrase (IN). The majority of compounds were designed as geometrically or conformationally constrained analogues of caffeic acid phenethyl e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::18c8a4b53cbbf5d5d858ec0f5c1ed277
https://doi.org/10.1021/jm9707232
https://doi.org/10.1021/jm9707232
Autor:
Maurizio Botta, Augusto Gambacorta, A. Pani, P. La Colla, Marco Artico, M. E. Marongiu, Silvio Massa
Publikováno v:
ChemInform. 23
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c02373c6c6b99ff693ec0b8fc6447359
https://doi.org/10.1002/chin.199239211
https://doi.org/10.1002/chin.199239211
Publikováno v:
Antiviral chemistrychemotherapy. 12
Worldwide, the heterosexual route is the prevalent mode of transmission of AIDS; therefore, demands have been raised for measures that block sexual spreading of the HIV infection. Development of microbicides for topical use may represent an efficacio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::0d6542065935920986c41a0af19fb0d2
https://pubmed.ncbi.nlm.nih.gov/11594689
https://pubmed.ncbi.nlm.nih.gov/11594689
Autor:
P. La Colla, Enzo Tramontano, Silvio Massa, M. E. Marongiu, Gianluca Sbardella, A. G. Loi, Ettore Novellino, Antonello Mai, Giovanni Greco, Marino Artico
Publikováno v:
Journal of medicinal chemistry. 42(4)
Molecular modeling analysis of compounds belonging to the recently published series of dihydro-alkoxy-benzyl-oxopyrimidines (DABOs), such as S-DABOs and DATNOs, gave support to the design of new 2, 6-disubstituted benzyl-DABO derivatives as highly po
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f9abb2236bb5c080d1d34c4f24f90474
https://pubmed.ncbi.nlm.nih.gov/10052969
https://pubmed.ncbi.nlm.nih.gov/10052969
Autor:
P, Franchetti, P, Perlini, G, Abu Sheikha, L, Cappellacci, M, Grifantini, A G, Loi, A, De Montis, A, Pani, M E, Marongiu, P, La Colla
Publikováno v:
Antiviral chemistrychemotherapy. 9(4)
A series of human immunodeficiency virus (HIV) protease inhibitors, which are analogues of N-[2(R)-hydroxy-1(S)- indanyl]-5(S)-[(tert-butyloxycarbonyl)amino]-4(S)-hydroxy-6-phenyl-2-(R) - [[4-(carboxymethoxy)phenyl]methyl]hexanamide (L-694,746), a me
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::f8bd43fef900af257319ce9319b71799
https://pubmed.ncbi.nlm.nih.gov/9875409
https://pubmed.ncbi.nlm.nih.gov/9875409
Autor:
C B, Vicentini, S, Manfredini, M, Manfrini, R, Bazzanini, C, Musiu, M, Putzolu, G, Perra, M E, Marongiu
Publikováno v:
Archiv der Pharmazie. 331(9)
In view of the biological relevance of triazole-based heterocyclic structures as antifungal, antiviral, and antitumor agents, we have synthesized a series of substituted pyrazolo[3,4-d]-1,2,3-triazoles (2e-h, 2j, 4b) which we evaluated for their cyto
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::a7afad2c4b73a1f2db49402cb369f828
https://pubmed.ncbi.nlm.nih.gov/9793481
https://pubmed.ncbi.nlm.nih.gov/9793481
Autor:
A, Pani, M E, Marongiu, E, Pinna, F, Scintu, G, Perra, A D, Montis, S, Manfredini, P, La Colla
Publikováno v:
Anticancer research. 18(4A)
IPCAR is a pyrazole nucleoside analog which belongs to a class of compounds structurally related to the inosine monophosphate (IMP) dehydrogenase (IMPDH) inhibitors ribavirin, selenazofurin and tiazofurin. Unlike other anticancer drugs, IPCAR showed
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::27206cfd322cc86551fa1dcb1e46fbf7
https://pubmed.ncbi.nlm.nih.gov/9703919
https://pubmed.ncbi.nlm.nih.gov/9703919
Autor:
A M, Almerico, P, Diana, P, Barraja, G, Dattolo, F, Mingoia, M, Putzolu, G, Perra, C, Milia, C, Musiu, M E, Marongiu
Publikováno v:
Farmaco (Societa chimica italiana : 1989). 52(11)
The series of 1-(1,3-dihydroxy-2-propoxy)methylpyrroles 2a-o were prepared in good overall yields according to Scheme I. When evaluated for antiviral activity against HIV-1, only compounds of the triphenyl series (R3 = NH2, N3, Br) were found to inhi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::0091ae88c83673aa541ccc31d9044391
https://pubmed.ncbi.nlm.nih.gov/9550092
https://pubmed.ncbi.nlm.nih.gov/9550092
Publikováno v:
The new microbiologica. 18(4)
2',3'-dideoxyadenosine (ddAdo) and 2',3'-dideoxyinosine (ddIno) are potent and selective inhibitors of the replication of the human immunodeficiency virus type 1 (HIV1) in several cell culture systems. Equipotent in terms of antiviral activity, both
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::4906c9cc6ec8f3dfb52ae9580d3eddc8
https://pubmed.ncbi.nlm.nih.gov/8590388
https://pubmed.ncbi.nlm.nih.gov/8590388
Autor:
E, Tramontano, M E, Marongiu, A, de Montis, A G, Loi, M, Artico, S, Massa, A, Mai, P, la Colla
Publikováno v:
The new microbiologica. 17(4)
Novel 3,4-dihydro-6-benzyl-4-oxopyrimidines (DABOs), variously substituted at both the C-2 and C-5 positions of the pyrimidine ring, proved to be specific inhibitors of the human immunodeficiency virus type 1 (HIV-1) in vitro. Some compounds showed p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::9263aab01d683f5bda1c98f9f27871df
https://pubmed.ncbi.nlm.nih.gov/7532270
https://pubmed.ncbi.nlm.nih.gov/7532270