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An intracellular guanine nucleotide release protein for G0. GAP-43 stimulates isolated alpha subunits by a novel mechanism

Autor: Mark C. Fishman, M E Linder, Dario Valenzuela, Stephen M. Strittmatter, Y Sudo

Publikováno v: Journal of Biological Chemistry. 266:22465-22471

G protein-coupled membrane receptors activate G proteins by enhancing guanine nucleotide exchange. G0 is a major component of the growing regions (growth cones) of neurons. GAP-43 is a neuronal protein associated with the cytosolic face of the growth

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::d9cd53431664282dcbed9d6bfa8ccded
https://doi.org/10.1016/s0021-9258(18)54595-6

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Enrichment of G-protein palmitoyltransferase activity in low density membranes: in vitro reconstitution of Galphai to these domains requires palmitoyltransferase activity

Autor: J T, Dunphy, W K, Greentree, M E, Linder

Publikováno v: The Journal of biological chemistry. 276(46)

Many signaling proteins are targeted to low density, sphingomyelin- and cholesterol-enriched membranes, also called lipid rafts. These domains organize receptor-mediated signaling events at the plasma membrane. Fatty acylation is one mechanism for ta

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::3d678282e5e31396093a81ab33cf3fb6
https://pubmed.ncbi.nlm.nih.gov/11557754

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Role of the gamma subunit prenyl moiety in G protein beta gamma complex interaction with phospholipase Cbeta

Autor: V C, Fogg, I, Azpiazu, M E, Linder, A, Smrcka, S, Scarlata, N, Gautam

Publikováno v: The Journal of biological chemistry. 276(45)

The G protein betagamma complex regulates a wide range of effectors, including the phospholipase Cbeta isozymes (PLCbetas). Prenyl modification of the gamma subunit is necessary for this activity. Evidence presented here supports a direct interaction

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::58b106a98d72d2f6c224ed079ff89145
https://pubmed.ncbi.nlm.nih.gov/11546822

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Palmitoylation of G-protein alpha subunits

Autor: M E, Linder, C, Kleuss, S M, Mumby

Publikováno v: Methods in enzymology. 250

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::000f02ebb0a7113b88fc11d30a2edebb
https://pubmed.ncbi.nlm.nih.gov/7651161

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Expression of G-protein alpha subunits in Escherichia coli

Autor: E, Lee, M E, Linder, A G, Gilman

Publikováno v: Methods in enzymology. 237

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::4b7c87e2eb484faedd6c627776bbfe0a
https://pubmed.ncbi.nlm.nih.gov/7934993

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Myristoylation of G-protein alpha subunits

Autor: S M, Mumby, M E, Linder

Publikováno v: Methods in enzymology. 237

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::79ea90b122ae27fd254d0689e97fce9f
https://pubmed.ncbi.nlm.nih.gov/7935001

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Lipid modifications of G protein subunits. Myristoylation of Go alpha increases its affinity for beta gamma

Autor: M E, Linder, I H, Pang, R J, Duronio, J I, Gordon, P C, Sternweis, A G, Gilman

Publikováno v: The Journal of biological chemistry. 266(7)

Myristoylated recombinant proteins can be synthesized in Escherichia coli by concurrent expression of the enzyme myristoyl-CoA:protein N-myristoyl-transferase with its protein substrates (Duronio, R.J., Jackson-Machelski, E., Heuckeroth, R.O., Olins,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::154847eaca8590f00d336490ba630e7f
https://pubmed.ncbi.nlm.nih.gov/1900297

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Purification of recombinant Gi alpha and Go alpha proteins from Escherichia coli

Autor: M E, Linder, A G, Gilman

Publikováno v: Methods in enzymology. 195

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::3a3f9ad8aaea08a3b6fd1afcc6d0258d
https://pubmed.ncbi.nlm.nih.gov/1903487

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Purification and characterization of Go alpha and three types of Gi alpha after expression in Escherichia coli

Autor: M E, Linder, D A, Ewald, R J, Miller, A G, Gilman

Publikováno v: The Journal of biological chemistry. 265(14)

Complementary DNAs for the G protein alpha subunits Gi alpha 1, Gi alpha 2, Gi alpha 3, and Go alpha were expressed in Escherichia coli, and the four proteins were purified to homogeneity. The recombinant proteins exchange and hydrolyze guanine nucle

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::8f41656b9c6017d444061136c668151c
https://pubmed.ncbi.nlm.nih.gov/2159473

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Immunological characterization of proteins detected by phosphotyrosine antibodies in cells transformed by Rous sarcoma virus

Autor: M E Linder, John G. Burr

Publikováno v: Journal of Virology. 62:2665-2673

Phosphotyrosine antibodies were used to identify tyrosine-phosphorylated proteins in Rous sarcoma virus (RSV)-transformed chicken embryo fibroblasts. A large number of tyrosine phosphoproteins were detected. A similar set of proteins was observed in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::37c5fed6513c403614cb807fa7c51640
https://doi.org/10.1128/jvi.62.8.2665-2673.1988

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