Zobrazeno 1 - 6
of 6
pro vyhledávání: '"M E, Kyle"'
Publikováno v:
Biochemical pharmacology. 40(6)
Over the course of 4 hr, the metabolism of acetaminophen (APAP) by cultured rat hepatocytes resulted in a depletion of protein thiols and an accumulation of oxidized glutathione (GSSG) in the medium. With 20 mM APAP, arylation and the formation of gl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::6b916a357060b46d38c741500260d431
https://pubmed.ncbi.nlm.nih.gov/2403376
https://pubmed.ncbi.nlm.nih.gov/2403376
Publikováno v:
Laboratory investigation; a journal of technical methods and pathology. 62(6)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::42a97048dd3e9eb8170bec28ecd79d24
https://pubmed.ncbi.nlm.nih.gov/2162996
https://pubmed.ncbi.nlm.nih.gov/2162996
Publikováno v:
Molecular pharmacology. 37(3)
Pretreatment of cultured hepatocytes with the ferric iron chelator deferoxamine prevents the killing of the cells by tert-butyl hydroperoxide (TBHP). Incubation of the deferoxamine-pretreated hepatocytes in a serum-free medium containing only 0.25 nM
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::1a8fc6cdfeb43758ea29b25a8afce823
https://pubmed.ncbi.nlm.nih.gov/2314391
https://pubmed.ncbi.nlm.nih.gov/2314391
Publikováno v:
Molecular pharmacology. 34(4)
The toxicity of acetaminophen was studied in hepatocytes cultured from phenobarbital-induced male rats. Such cells were less sensitive to acetaminophen than similar ones cultured from animals induced with 3-methylcholanthrene. In both cases, the toxi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::531180798b237d2cd242aec051cb0781
https://pubmed.ncbi.nlm.nih.gov/3173337
https://pubmed.ncbi.nlm.nih.gov/3173337
Autor:
M E, Kyle, J J, Kocsis
Publikováno v:
Advances in experimental medicine and biology. 197
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::52a3a6ff0783030cc275e8c08861133a
https://pubmed.ncbi.nlm.nih.gov/3766290
https://pubmed.ncbi.nlm.nih.gov/3766290
Autor:
M E, Kyle, J J, Kocsis
Publikováno v:
Toxicology and applied pharmacology. 81(2)
The administration of 500 mg/kg sodium [14C]salicylate to 3- and 12-month-old male rats produced proximal tubular necrosis in the older animals but only mild nonspecific cellular changes in the younger group. The onset of renal damage was similar for
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::080d18d831e9dae04acb5cc7b16fc849
https://pubmed.ncbi.nlm.nih.gov/4060159
https://pubmed.ncbi.nlm.nih.gov/4060159