Výsledky vyhledávání - "M E, Hamrick"

Antagonism of acetaminophen hepatotoxicity by phospholipase A2 inhibitors

Autor: S R, Harris, M E, Hamrick

Publikováno v: Research communications in chemical pathology and pharmacology. 79(1)

A 250 mg/kg subcutaneous injection of acetaminophen (APAP) given to fasted mice was hepatotoxic as indicated by elevated serum alanine aminotransferase activity and electron microscopic studies. When extramitochondrial Ca2+ levels were 200 nM or grea

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::39e7c2f232c086c32e05f8d7056f9aea
https://pubmed.ncbi.nlm.nih.gov/8434130

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2-(beta-Arylethylamino)- and 4-(beta-arylethylamino)quinazolines as phosphodiesterase inhibitors

Autor: J. Millen, I. W. Waters, M. E. Hamrick, Thomas N. Riley

Publikováno v: Journal of medicinal chemistry. 28(1)

The existence of several forms of cAMP phosphodiesterase having differing kinetic characteristics suggests the feasibility of developing tissue-selective inhibitors of this enzyme. This observation is of particular importance in the development of th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d09b6d27a8dc295c9aa4ba1f1446f6ec
https://pubmed.ncbi.nlm.nih.gov/3965705

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Interaction of dantrolene with the hepatic mixed function oxidase system

Autor: S, Roy, F T, Francis, C K, Born, M E, Hamrick

Publikováno v: Research communications in chemical pathology and pharmacology. 27(3)

Dantrolene pretreatment of rats (100 mg/kg/day for five days) causes a fifty percent decrease in hepatic mixed function oxidase (MFO) system activity and a fifty percent decrease in cytochrome P450 content. Recovery of hepatic MFO system activity aft

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::3828315e735db80f4016709d4f8c4079
https://pubmed.ncbi.nlm.nih.gov/7384640

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Ferric ions located in hippocampal subfields of the mouse: effects on behavior

Autor: C A, Boast, S F, Zornetzer, M E, Hamrick

Publikováno v: T.-I.-T. journal of life sciences. 5(1-2)

Using stereotaxic techniques mice were chronically implanted with either stainless steel or platinum-iridium wire probes aimed at the dentate gyrus of the hippocampus. Following a recovery period these mice were trained in a single-trial inhibitor av

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::7c092d3c777e948d44b96e7c9b8ce7e9
https://pubmed.ncbi.nlm.nih.gov/1188934

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Inhibition of the positive atrial chronotropic effect of isoproterenol by exposure to an acrylate floor finish

Autor: M J, Campbell, D W, Willis, M E, Hamrick, C K, Born

Publikováno v: Research communications in chemical pathology and pharmacology. 51(1)

Application of a commercial acrylate sealer/finish to the floor of our animal quarters resulted in almost complete elimination of the positive chronotropic response of the hypoxic rat atria to isoproterenol. Forty-eight hours exposure to this sealer/

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::4477b8766c7c64d9b16e4ae6ab615bed
https://pubmed.ncbi.nlm.nih.gov/3952368

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Inhibition of carbon tetrachloride induced hepatotoxicity by dantrolene sodium

Autor: L S, Steinhauer, J L, Joyave, C P, Davidson, C K, Born, M E, Hamrick

Publikováno v: Research communications in chemical pathology and pharmacology. 52(1)

A 50 mg/kg dose of dantrolene sodium decreased the hepatotoxicity of carbon tetrachloride in fed and fasted rats, as indicated by lower levels of SGPT following a toxic dose of carbon tetrachloride; however, the dantrolene sodium pretreatment did not

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::18a6750c90c71aa47348a15c6c027484
https://pubmed.ncbi.nlm.nih.gov/3012725

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Inhibition of isoproterenol positive atrial chronotropic effect by methylmethacrylate polymer and monomer

Autor: D W, Willis, M J, Campbell, W R, Ravis, M E, Hamrick, C K, Born

Publikováno v: Research communications in chemical pathology and pharmacology. 53(1)

Atria from rats exposed in vivo to methylmethacrylate polymer or monomer were superfused and chronotropic responses to isoproterenol determined. Control and polymer-exposed atria superfused with oxygen-saturated buffer yielded dose-response curves wh

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::78d04765a0e59e20c81035754e4ed565
https://pubmed.ncbi.nlm.nih.gov/3749605

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Alteration of digoxin toxicity by 6-hydroxydopamine and soironolactone

Autor: J C, Anders, F J, Crisona, M E, Hamrick

Publikováno v: Research communications in chemical pathology and pharmacology. 29(3)

The possibility that the Na+-K+ ATPase of cardiac adrenergic neurons is the toxic receptor site of cardiac glycosides was investigated by performing a chemical sympathectomy in dogs using 6-hydroxydopamine to destroy the adrenergic neurons. No altera

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::3ddf17644a96b2a5b924cace13aa7a9f
https://pubmed.ncbi.nlm.nih.gov/7423022

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