Výsledky vyhledávání - "M E, Federici"

Combination therapy with stavudine and didanosine in children with advanced human immunodeficiency virus infection: pharmacokinetic properties, safety, and immunologic and virologic effects

Autor: M W, Kline, C V, Fletcher, M E, Federici, A T, Harris, K D, Evans, V L, Rutkiewicz, W T, Shearer, L M, Dunkle

Publikováno v: Pediatrics. 97(6 Pt 1)

To obtain preliminary information on the pharmacokinetic properties, tolerance, safety, and antiviral activity of combination therapy with stavudine and didanosine in children with advanced human immunodeficiency virus (HIV) infection.Eight children

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::482b344df873fa665d3e2a1f56b14af9
https://pubmed.ncbi.nlm.nih.gov/8657531

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A phase I/II evaluation of stavudine (d4T) in children with human immunodeficiency virus infection

Autor: M W, Kline, L M, Dunkle, J A, Church, J C, Goldsmith, A T, Harris, M E, Federici, M E, Schultze, L, Woods, D F, Loewen, S, Kaul

Publikováno v: Pediatrics. 96(2 Pt 1)

To determine the pharmacokinetic properties, tolerance, safety, and preliminary activity of stavudine in human immunodeficiency virus (HIV)-infected children.Phase I/II, open and dose-ranging (0.125 to 4 mg/kg/day in two divided doses).Thirty-seven H

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::a4a6afc6e5e9bd19c93b4a67e1ee7676
https://pubmed.ncbi.nlm.nih.gov/7630678

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Genotypic and phenotypic analysis of human immunodeficiency virus type 1 isolates from patients on prolonged stavudine therapy

Autor: P.-F. Lin, H. Samanta, R. E. Rose, A. K. Patick, J. Trimble, C. M. Bechtold, D. R. Revie, N. C. Khan, M. E. Federici, H. Li, A. Lee, R. E. Anderson, R. J. Colonno

Publikováno v: The Journal of infectious diseases. 170(5)

Development of stavudine resistance was studied using human immunodeficiency virus type 1 isolates from 13 patients treated with stavudine for 18-22 months. Drug sensitivity testing on 11 of these pre- and posttherapy isolates identified only 2 postt

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4916112d636fc8c408959d05e5fc38f8
https://pubmed.ncbi.nlm.nih.gov/7963708

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Non-prostanoid prostacyclin mimetics. 6. Derivatives of 2-[3-[2-(4,5-Diphenyl-2-oxazolyl)ethyl]phenoxy]acetic acid modified beta-to the oxazole ring

Autor: N A, Meanwell, M J, Rosenfeld, A K, Trehan, J J, Wright, C L, Brassard, J O, Buchanan, M E, Federici, J S, Fleming, M, Gamberdella, K S, Hartl

Publikováno v: Drug design and discovery. 11(1)

2-[3-[2-(4,5-Diphenyl-2-oxazolyl)ethyl]phenoxy]acetic acid, 1, has been described as a non-prostanoid PGI2 mimetic that demonstrates anti-thrombotic properties of long duration in animal models of thrombosis. The effects of substitution and modificat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::dd302b8fc14602beae6edb4ff879ef0e
https://pubmed.ncbi.nlm.nih.gov/7520762

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Nonprostanoid prostacyclin mimetics. 2. 4,5-Diphenyloxazole derivatives

Autor: N A, Meanwell, M J, Rosenfeld, A K, Trehan, J J, Wright, C L, Brassard, J O, Buchanan, M E, Federici, J S, Fleming, M, Gamberdella, G B, Zavoico

Publikováno v: Journal of medicinal chemistry. 35(19)

4,5-Diphenyl-2-oxazolenonanoic acid (18b) was synthesized and found to inhibit ADP-induced aggregation of human platelets with an IC50 of 2.5 microM. Acid 18b displaced [3H]iloprost from human platelet membranes in a concentration-dependent fashion,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::deb469276b75ebdbe0342d149073f522
https://pubmed.ncbi.nlm.nih.gov/1404230

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