Výsledky vyhledávání

Elective Surgical Delays Due to COVID-19: The Patient Lived Experience: Erratum

Autor: C. S. Brown, M. E. Byrnes, R. A. C. De

Publikováno v: Medical Care

This qualitative research explored the lived experiences of patients who experienced postponement of elective cardiac and vascular surgery due to coronavirus disease 2019 (COVID-19). We know very little about patients during the novel coronavirus pan

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::155643eb6d224a5f5baa96ff536f94b7
https://doi.org/10.1097/mlr.0000000000001615

Zobrazit plný text záznamu

Chemical synthesis and characterization of ShK toxin: a potent potassium channel inhibitor from a sea anemone

Autor: V.M. Mahnir, M. E. Byrnes, William R. Kem, W .A. Volberg, Ilya Khaytin, D.S. Krafte, William P. Gorczyca, I. Zaydenberg, Michael W. Pennington, R. Hill, J. de Chastonay

Publikováno v: International Journal of Peptide and Protein Research. 46:354-358

ShK-toxin, a 35 residue peptide isolated from the sea anemone Stichodactyla helianthus, was synthesized using an Fmoc strategy and successfully folded to the biologically active form containing three intramolecular disulfide bonds. The ability of syn

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::98bd44f894a140117f8f73f6b4ed18a3
https://doi.org/10.1111/j.1399-3011.1995.tb01068.x

Zobrazit plný text záznamu

Identification of Three Separate Binding Sites on SHK Toxin, a Potent Inhibitor of Voltage-Dependent Potassium Channels in Human T-Lymphocytes and Rat Brain

Autor: I. Zaydenberg, Michael W. Pennington, William R. Kem, Ilya Khaytin, K. Crowley, D.S. Krafte, V.M. Mahnir, M. E. Byrnes

Publikováno v: Biochemical and Biophysical Research Communications. 219:696-701

Eighteen synthetic analogs of ShK toxin, a thirty-five residue K channel blocker derived from the sea anemone Stichodactyla helianthus, were prepared in order to identify functionally important residues. CD spectra of sixteen of the analogs were virt

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8950cf70929191f8371359a6ed57c402
https://doi.org/10.1006/bbrc.1996.0297

Zobrazit plný text záznamu

An Essential Binding Surface for ShK Toxin Interaction with Rat Brain Potassium Channels

Autor: William R. Kem, I. Zaydenberg, M. E. Byrnes, Michael W. Pennington, V.M. Mahnir, Ilya Khaytin

Publikováno v: Biochemistry. 35:16407-16411

An "Ala scan" analysis of ShK toxin, a 35-residue basic peptide possessing three disulfide bonds, identifies seven side chains which influence binding to brain delayed rectifier potassium channels. Additional analogs were synthesized and tested to fu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e632f1f3ff8d65448e196bb31baac3ce
https://doi.org/10.1021/bi962463g

Zobrazit plný text záznamu

Synthesis and structural characterisation of analogues of the potassium channel blocker charybdotoxin

Autor: Raymond S. Norton, Michael W. Pennington, Brendan M. Duggan, Timothy R. Dyke, William R. Kem, M. E. Byrnes

Publikováno v: Biochimica et Biophysica Acta (BBA) - Protein Structure and Molecular Enzymology. 1292:31-38

Charybdotoxin is a 37-residue polypeptide toxin from scorpion venom, which acts by blocking voltage-gated and Ca(2+)-activated K+ channels. We have synthesized charybdotoxin and three mono-substituted analogues using an Fmoc-tBu protocol. The Phe-2 -

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::73c2b0a669ce3a58311a6ea10bbae26a
https://doi.org/10.1016/0167-4838(95)00182-4

Zobrazit plný text záznamu

Assignment of the three disulfide bonds in ShK toxin: A potent potassium channel inhibitor from the sea anemone Stichodactyla helianthus

Autor: Kurt R. Nielsen, Amina S. Woods, Jan Pohl, Michael W. Pennington, M. E. Byrnes, Frantisek Hubalek

Publikováno v: Letters in Peptide Science. 1:291-297

ShK toxin, a 35-residue peptide isolated from the Caribbean sea anemone Stichodactyla helianthus, is a potent inhibitor of the Kv 1.3 potassium channel in lymphocytes. The natural toxin contains three disulfide bonds. The disulfide pairings of the sy

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::f7b69e14d3aca86139face5b76515f30
https://doi.org/10.1007/bf00119770

Zobrazit plný text záznamu

Synthesis and Characterization of Dendrotoxin: A Potent Potassium Channel Inhibitor

Autor: M. E. Byrnes, V.M. Mahnir, W.R. Kem, M. W. Pennington

Publikováno v: Protein & Peptide Letters. 1:239-245

Dendrotoxin, a 59 residue peptide toxin was synthesized using an Fmoc-tBu strategy and folded to the biologically active form . Synthetic dendrotoxin co-eluted with the natural toxin by RP-HPLC, and inhibited [125]-dendrotoxin I binding to rat brain

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::881420e6d88f89851104e4f187de5de2
https://doi.org/10.2174/0929866501666220517214555

Zobrazit plný text záznamu

Vyhledávací nástroje:

Upřesnit hledání