Zobrazeno 1 - 10 of 669 pro vyhledávání: '"M Drouin"'
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Akademický článek
Proteomic analysis of APOEε4 carriers implicates lipid metabolism, complement and lymphocyte signaling in cognitive resilience
Autor: Keenan A. Walker, Yang An, Abhay Moghekar, Ruin Moaddel, Michael R. Duggan, Zhongsheng Peng, Qu Tian, Luke C. Pilling, Shannon M. Drouin, Mark A. Espeland, Stephen R Rapp, Kathleen M Hayden, Aladdin H. Shadyab, Ramon Casanova, Madhav Thambisetty, Peter R. Rapp, Dimitrios Kapogiannis, Luigi Ferrucci, Susan M. Resnick
Publikováno v: Molecular Neurodegeneration, Vol 19, Iss 1, Pp 1-18 (2024)
Abstract Background Apolipoprotein E (APOE) ε4 allele is the strongest genetic risk factor for late onset Alzheimer’s disease (AD). This case-cohort study used targeted plasma biomarkers and large-scale proteomics to examine the biological mechani
Externí odkaz: https://doaj.org/article/ee7fd18cf0994326a5954b2b904a2e34
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2
Akademický článek
Machine learning analyses identify multi-modal frailty factors that selectively discriminate four cohorts in the Alzheimer’s disease spectrum: a COMPASS-ND study
Autor: Linzy Bohn, Shannon M. Drouin, G. Peggy McFall, Darryl B. Rolfson, Melissa K. Andrew, Roger A. Dixon
Publikováno v: BMC Geriatrics, Vol 23, Iss 1, Pp 1-18 (2023)
Abstract Background Frailty indicators can operate in dynamic amalgamations of disease conditions, clinical symptoms, biomarkers, medical signals, cognitive characteristics, and even health beliefs and practices. This study is the first to evaluate w
Externí odkaz: https://doaj.org/article/fe0d9a2ae7bf4d159f8911aff0474e3b
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3
Akademický článek
Gender specific factors contributing to cognitive resilience in APOE ɛ4 positive older adults in a population-based sample
Autor: Lidan Zheng, Ranmalee Eramudugolla, Nicolas Cherbuin, Shannon M. Drouin, Roger A. Dixon, Kaarin J. Anstey
Publikováno v: Scientific Reports, Vol 13, Iss 1, Pp 1-9 (2023)
Abstract Although APOE ɛ4 has been identified as the strongest genetic risk factor for Alzheimer’s Disease, there are some APOE ɛ4 carriers who do not go on to develop Alzheimer’s disease or cognitive impairment. This study aims to investigate
Externí odkaz: https://doaj.org/article/26f3cd784f384dd2a96e54fe1a354ea6
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4
Akademický článek
A Comprehensive Study of the Effects by Sequence Truncation within Inverted Terminal Repeats (ITRs) on the Productivity, Genome Packaging, and Potency of AAV Vectors
Autor: Yinxing Chen, Shiliang Hu, William Lee, Noel Walsh, Kayla Iozza, Neil Huang, Gregory Preston, Lauren M. Drouin, Nannan Jia, June Deng, Matthias Hebben, Jing Liao
Publikováno v: Microorganisms, Vol 12, Iss 2, p 310 (2024)
One of the primary challenges in working with adeno-associated virus (AAV) lies in the inherent instability of its inverted terminal repeats (ITRs), which play vital roles in AAV replication, encapsidation, and genome integration. ITRs contain a high
Externí odkaz: https://doaj.org/article/55b423e76b5c4528bcaaa86d72561929
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5
Akademický článek
Identifying key multi-modal predictors of incipient dementia in Parkinson’s disease: a machine learning analysis and Tree SHAP interpretation
Autor: G. Peggy McFall, Linzy Bohn, Myrlene Gee, Shannon M. Drouin, Harrison Fah, Wei Han, Liang Li, Richard Camicioli, Roger A. Dixon
Publikováno v: Frontiers in Aging Neuroscience, Vol 15 (2023)
BackgroundPersons with Parkinson’s disease (PD) differentially progress to cognitive impairment and dementia. With a 3-year longitudinal sample of initially non-demented PD patients measured on multiple dementia risk factors, we demonstrate that ma
Externí odkaz: https://doaj.org/article/cb57e9deb24a42a8a198cfbbbdfcdd56
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6
Traitement des effluents de désulfuration des gaz d’échappement des navires de transport maritime par filtration membranaire
Autor: M. DROUIN, G. PARRAVICINI, S. NASSER, P. MOULIN
Publikováno v: Techniques Sciences Méthodes. :27-39
En 2020, la concentration en oxyde de soufre autorisée dans les fumées de gaz d’échappement des bateaux de la marine marchande a été réduite d’un facteur 7 par l’Organisation maritime internationale. Pour satisfaire ces nouvelles normes d
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::bebe1341eaf03c137515013235951965
https://doi.org/10.36904/202301027
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7
Akademický článek
In multiple facets of subjective memory decline sex moderates memory predictions
Autor: Shannon M. Drouin, G. Peggy McFall, Roger A. Dixon
Publikováno v: Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring, Vol 12, Iss 1, Pp n/a-n/a (2020)
Abstract Introduction Two established subjective memory decline facets (SMD; complaints, concerns) are early indicators of memory decline and Alzheimer's disease. We report (1) a four‐facet SMD inventory (memory complaints, concerns, compensation,
Externí odkaz: https://doaj.org/article/3d2f02abe72d4ed897be2c160f2a7c47
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8
Akademický článek
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9
Subjective memory concerns, poor vascular health, and male sex predict exacerbated memory decline trajectories: An integrative data-driven class and prediction analysis
Autor: G. Peggy McFall, Shannon M. Drouin, Roger A. Dixon
Publikováno v: Neuropsychology
OBJECTIVE Subjective memory decline (SMD) has been identified as a potential early marker of nonnormal and accelerated cognitive decline. We performed data-driven analyses that integrated trajectory classification with prediction modeling to test dec
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e37ecaf31d0f76a77ed1163c42d5aec5
https://doi.org/10.1037/neu0000784
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10
Akademický článek
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