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Akademický článek

Multimodal genome-wide survey of progressing and non-progressing breast ductal carcinoma in-situ

Publikováno v: Breast Cancer Research, Vol 26, Iss 1, Pp 1-15 (2024)

Abstract Background Ductal carcinoma in-situ (DCIS) is a pre-invasive form of invasive breast cancer (IBC). Due to improved breast cancer screening, it now accounts for ~ 25% of all breast cancers. While the treatment success rates are over 90%, this

Externí odkaz: https://doaj.org/article/a106b36b520948e78078f14a3c21f70b

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Akademický článek

Parkinson’s Disease: A Narrative of the Evolving Understanding of the Role of α-Synuclein in Screening

Autor: Alan D. Kaye, Kassady A. Perkinson, Noah J. Spillers, Alexis J. Vega, Caylin J. Roberts, Evan M. Downs, Melissa M. Sheth, David W. McGregor, Shahab Ahmadzadeh, Jibin Mathew, Sahar Shekoohi

Publikováno v: Current Issues in Molecular Biology, Vol 46, Iss 11, Pp 12746-12755 (2024)

The present investigation aims to examine the role of α-synuclein seed amplification assays for screening Parkinson’s disease. Parkinson’s disease (PD) is a debilitating neurodegenerative disorder caused by the loss of dopaminergic neurons in th

Externí odkaz: https://doaj.org/article/e2647ba951444d35be4036e8b31748cb

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Akademický článek

RidA proteins contribute to fitness of S. enterica and E.coli by reducing 2AA stress and moderating flux to isoleucine biosynthesis

Autor: Ronnie L. Fulton, Bryce R. Sawyer, Diana M Downs

Publikováno v: Microbial Cell, Vol 11, Pp 339-352 (2024)

Defining the physiological role of a gene product relies on interpreting phenotypes caused by the lack, or alteration, of the respective gene product. Mutations in critical genes often lead to easily recognized phenotypes that can include changes in

Externí odkaz: https://doaj.org/article/fc39ba40cef346aa9fc66aa2bef13cf8

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Akademický článek

Real-world effectiveness and causal mediation study of BNT162b2 on long COVID risks in children and adolescentsResearch in context

Publikováno v: EClinicalMedicine, Vol 79, Iss , Pp 102962- (2025)

Summary: Background: The impact of pre-infection vaccination on the risk of long COVID remains unclear in the pediatric population. We aim to assess the effectiveness of BNT162b2 on long COVID risks with various strains of the SARS-CoV-2 virus in chi

Externí odkaz: https://doaj.org/article/07113564bd944de1a14bb0a80886c1e1

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Akademický článek

Purine limitation prevents the exogenous pyridoxal 5′-phosphate accumulation of Salmonella enterica yggS mutants

Autor: Kailey S. Ezekiel, Diana M. Downs

Publikováno v: Microbiology Spectrum, Vol 12, Iss 12 (2024)

ABSTRACT YggS belongs to the highly conserved pyridoxal 5′-phosphate (PLP) binding protein family (COG0325) that is found in all domains of life. Though no precise biochemical activity or molecular mechanism has been determined for this protein, an

Externí odkaz: https://doaj.org/article/5acc45aabb3241ffa6e431a3ffb1115b

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Akademický článek

Oral fentanyl consumption and withdrawal impairs fear extinction learning and enhances basolateral amygdala principal neuron excitatory-inhibitory balance in male and female mice

Autor: Anthony M. Downs, Gracianne Kmiec, Zoé A. McElligott

Publikováno v: Addiction Neuroscience, Vol 13, Iss , Pp 100182- (2024)

The number of opioid overdose deaths has increased over the past several years, mainly driven by an increase in the availability of highly potent synthetic opioids, like fentanyl, in the un-regulated drug supply. Over the last few years, changes in t

Externí odkaz: https://doaj.org/article/b971f853e54f4f1c8e93848cd94b7c37

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Review

The Golden Ghetto: The American Commercial Community at Canton and the Shaping of American China Policy, 1784–1844 Jacques M. Downs

Autor: Van Dyke, Paul

Publikováno v: Journal of the Royal Asiatic Society Hong Kong Branch, 2015 Jan 01. 55, 216-218.

Externí odkaz: https://www.jstor.org/stable/jroyaaisasocihkb.55.216

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Akademický článek

Applied Research Note: The impact of retention time during the conditioning process of a broiler starter diet on performance, apparent metabolizable energy, and apparent ileal digestibility of nutrients

Autor: Joseph P. Gulizia, Abigail D. McConnell, Rachel E. Strobeck, Cecilia M. Broadwater, Eva G. Guzman, Cristina T. Simões, Jose R. Hernandez, Wilmer J. Pacheco, Kevin M. Downs

Publikováno v: Journal of Applied Poultry Research, Vol 33, Iss 3, Pp 100435- (2024)

SUMMARY: Understanding the influence of feed processing on early broiler growth is essential for maintaining production and increasing profit. The purpose of this research was to assess the effects of 3 retention times (RT) during the conditioning pr

Externí odkaz: https://doaj.org/article/435d11c7e48f45168f2eede6b0fe45df

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