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Akademický článek

An optimized bicistronic chimeric antigen receptor against GPC2 or CD276 overcomes heterogeneous expression in neuroblastoma

Publikováno v: The Journal of Clinical Investigation, Vol 132, Iss 16 (2022)

Chimeric antigen receptor (CAR) T cell therapies targeting single antigens have performed poorly in clinical trials for solid tumors due to heterogenous expression of tumor-associated antigens (TAAs), limited T cell persistence, and T cell exhaustion

Externí odkaz: https://doaj.org/article/114fac18c13d4632b85c061e52d66443

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Akademický článek

CAR T cells targeting tumor-associated exons of glypican 2 regress neuroblastoma in mice

Autor: Nan Li, Madeline B. Torres, Madeline R. Spetz, Ruixue Wang, Luyi Peng, Meijie Tian, Christopher M. Dower, Rosa Nguyen, Ming Sun, Chin-Hsien Tai, Natalia de Val, Raul Cachau, Xiaolin Wu, Stephen M. Hewitt, Rosandra N. Kaplan, Javed Khan, Brad St Croix, Carol J. Thiele, Mitchell Ho

Publikováno v: Cell Reports Medicine, Vol 2, Iss 6, Pp 100297- (2021)

Summary: Targeting solid tumors must overcome several major obstacles, in particular, the identification of elusive tumor-specific antigens. Here, we devise a strategy to help identify tumor-specific epitopes. Glypican 2 (GPC2) is overexpressed in ne

Externí odkaz: https://doaj.org/article/1562370b31514de19b560ba348a2c0f6

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Akademický článek

Reaching Agreement in Quantum Hybrid Networks

Autor: Guodong Shi, Bo Li, Zibo Miao, Peter M. Dower, Matthew R. James

Publikováno v: Scientific Reports, Vol 7, Iss 1, Pp 1-9 (2017)

Abstract We consider a basic quantum hybrid network model consisting of a number of nodes each holding a qubit, for which the aim is to drive the network to a consensus in the sense that all qubits reach a common state. Projective measurements are ap

Externí odkaz: https://doaj.org/article/28ab0592a5554d68b130466e64c6a44b

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A Game Representation for a Finite Horizon State Constrained Continuous Time Linear Regulator Problem

Autor: Peter M. Dower, William M. McEneaney, Michael Cantoni

Publikováno v: Applied Mathematics & Optimization. 88

A supremum-of-quadratics representation for a class of extended real valued barrier functions is developed and applied in the context of solving a continuous time linear regulator problem subject to a single state constraint of bounded norm. It is sh

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::141ad932037ae08f3c4cc6915ecb3c50
https://doi.org/10.1007/s00245-023-09972-6

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Data from Chemotherapy-Induced Upregulation of Small Extracellular Vesicle-Associated PTX3 Accelerates Breast Cancer Metastasis

Autor: Hong-Gang Wang, Jeffrey Sundstrom, Christopher M. Dower, Yuanjun Zhao, Longgui Chen, Xiaoming Liu, Carson A. Wills

Although neoadjuvant chemotherapy is a standard component of breast cancer treatment, recent evidence suggests that chemotherapeutic drugs can promote metastasis through poorly defined mechanisms. Here we utilize xenograft mouse models of triple-nega

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::54c4c984894a5fe98405ea09a63f1884
https://doi.org/10.1158/0008-5472.c.6512464.v1

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