Zobrazeno 1 - 10
of 352
pro vyhledávání: '"M Douek"'
Autor:
Rita J. Serrano, Clara Lee, Alon M. Douek, Jan Kaslin, Robert J. Bryson-Richardson, Tamar E. Sztal
Publikováno v:
Disease Models & Mechanisms, Vol 15, Iss 3 (2022)
Cyclin-dependent kinase-like-5 (CDKL5) deficiency disorder (CDD) is a severe X-linked neurodegenerative disease characterised by early-onset epileptic seizures, low muscle tone, progressive intellectual disability and severe motor function. CDD affec
Externí odkaz:
https://doaj.org/article/350b55da664c4c53a07704acd77dfab0
Autor:
Nhi Hin, Morgan Newman, Jan Kaslin, Alon M Douek, Amanda Lumsden, Seyed Hani Moussavi Nik, Yang Dong, Xin-Fu Zhou, Noralyn B Mañucat-Tan, Alastair Ludington, David L Adelson, Stephen Pederson, Michael Lardelli
Publikováno v:
PLoS ONE, Vol 15, Iss 1, p e0227258 (2020)
BACKGROUND:The molecular changes involved in Alzheimer's disease (AD) progression remain unclear since we cannot easily access antemortem human brains. Some non-mammalian vertebrates such as the zebrafish preserve AD-relevant transcript isoforms of t
Externí odkaz:
https://doaj.org/article/03c0068989154a2db2a04048633ea4c2
Autor:
Alon M. Douek, Mitra Amiri Khabooshan, Jason Henry, Sebastian-Alexander Stamatis, Florian Kreuder, Georg Ramm, Minna-Liisa Änkö, Donald Wlodkowic, Jan Kaslin
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 11, p 5948 (2021)
Mucopolysaccharidosis IIIA (MPS IIIA, Sanfilippo syndrome type A), a paediatric neurological lysosomal storage disease, is caused by impaired function of the enzyme N-sulfoglucosamine sulfohydrolase (SGSH) resulting in impaired catabolism of heparan
Externí odkaz:
https://doaj.org/article/2b8c5cdfa1064347a63ff21cb1db2993
Akademický článek
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Publikováno v:
Frontiers in Neuroscience, Vol 11 (2018)
The field of macro-imaging has grown considerably with the appearance of innovative clearing methods and confocal microscopes with lasers capable of penetrating increasing tissue depths. The ability to visualize and model the growth of whole organs a
Externí odkaz:
https://doaj.org/article/f7cd24fac7554c7c866fbf21fee4a436
Autor:
Alon M Douek, Abbas Salavaty, Florian Kreuder, Sebastian-Alexander Stamatis, Joel R Steele, Iresha Hanchapola, Anup D Shah, Ralf B Schittenhelm, Mirana Ramialison, Peter D Currie, Jan Kaslin
Mucopolysaccharidoses are lysosomal storage diseases that collectively represent a major cause of lethal, treatment-refractory childhood dementias 1–7 Clinically-useful interventions are hampered due to an incomplete understanding of their neuropat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0f6830f198a248d2772208598c3f9520
https://doi.org/10.1101/2022.10.03.510585
https://doi.org/10.1101/2022.10.03.510585
Autor:
Yuhuan Li, Yanting Xing, Andrew K. Whittaker, Ibrahim Javed, Alon M. Douek, Aleksandr Kakinen, Ruirui Qiao, Kairi Koppel, Changkui Fu, Xulin Wan, Zhiyuan Song, Fangyun Xin, Nicholas Andrikopoulos, Thomas P. Davis, Jan Kaslin, Pu Chun Ke, Yang Song, Feng Ding
Publikováno v:
Chem Mater
Amyloid aggregation is a ubiquitous form of protein misfolding underlying the pathologies of Alzheimer’s disease (AD), Parkinson’s disease (PD), and type 2 diabetes (T2D), three primary forms of human amyloid diseases. While much has been learned
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e1bedce2b4d13f55524b98758de0a64d
https://doi.org/10.1021/acs.chemmater.1c01947
https://doi.org/10.1021/acs.chemmater.1c01947
Akademický článek
Tento výsledek nelze pro nepřihlášené uživatele zobrazit.
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K zobrazení výsledku je třeba se přihlásit.
Autor:
Sebastian-Alexander Stamatis, Minna-Liisa Änkö, Jason Henry, Alon M. Douek, Mitra Khabooshan, Florian Kreuder, Jan Kaslin, Donald Wlodkowic, Georg Ramm
Publikováno v:
International Journal of Molecular Sciences
Volume 22
Issue 11
International Journal of Molecular Sciences, Vol 22, Iss 5948, p 5948 (2021)
Volume 22
Issue 11
International Journal of Molecular Sciences, Vol 22, Iss 5948, p 5948 (2021)
Mucopolysaccharidosis IIIA (MPS IIIA, Sanfilippo syndrome type A), a paediatric neurological lysosomal storage disease, is caused by impaired function of the enzyme N-sulfoglucosamine sulfohydrolase (SGSH) resulting in impaired catabolism of heparan
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3dc56af47e14587a37c7fb7b49a31682
https://trepo.tuni.fi/handle/10024/142583
https://trepo.tuni.fi/handle/10024/142583
Autor:
Alon M. Douek, Jean K. Tang, Jan Kaslin, Benjamin W. Lindsey, Celia Vandestadt, Georgia E. Aitken, Mitra Khabooshan
Publikováno v:
Scientific Reports, Vol 9, Iss 1, Pp 1-20 (2019)
Scientific Reports
Scientific Reports
How diverse adult stem and progenitor populations regenerate tissue following damage to the brain is poorly understood. In highly regenerative vertebrates, such as zebrafish, radial-glia (RG) and neuro-epithelial-like (NE) stem/progenitor cells contr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5e949c9c2a06b3cf293d391fcf8aeda3
http://link.springer.com/article/10.1038/s41598-019-40734-z
http://link.springer.com/article/10.1038/s41598-019-40734-z