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Autor:
Mauro Robello, R. Ferruzzi, M Di Braccio, Elena Gatta, Giancarlo Grossi, Giorgio Roma, Aroldo Cupello
Publikováno v:
Neuroscience. 166:917-923
Various new 1,5-benzodiazepine compounds were synthesized and tested for their biological activity in terms of effects on GABA A receptors of rat cerebellar granules in culture. Their effects were compared to those of a 1,4-benzodiazepine agonist, fl
Autor:
G, Roma, N, Cinone, M, Di Braccio, G, Grossi, G, Leoncini, M G, Signorello, A, Carotti, A, Carott
Publikováno v:
Bioorganic & Medicinal Chemistry. 8:751-768
2-(1-Piperazinyl)-4H-pyrido[1,2-a]pyrimidin-4-one Chart 5 , Scheme 2 Download : Download high-res image (50KB) Download : Download full-size image Chart 5 . Download : Download high-res image (186KB) Download : Download full-size image Scheme 2 . is
Autor:
Giancarlo Grossi, Mauro Robello, Aroldo Cupello, Elena Gatta, M Di Braccio, Periklis Nikas, Francesca Pellistri
Publikováno v:
Neuroscience. 243
In previous work our group described the synthesis and the activity on rat cerebellum granule cell GABAA receptors of new 1,5-benzodiazepine compounds. Here we are describing the synthesis of new triazolobenzodiazepines (mainly 1,5-benzodiazepine der
Publikováno v:
European Journal of Medicinal Chemistry. 30:27-38
Summary A number of 3-(dialkylamino)-1 H -pyrimido[1,2- a ]quinolin-1-ones 3 and 2-(dialkylamino)-4 H -pyrimido[2,1- a ] iso-quinolin-4-ones 4 were prepared by treating the corresponding chloro derivatives with an excess of dialkylamines. The highest
Publikováno v:
European Journal of Medicinal Chemistry. 28:577-584
The cyclocondensation of (dimethylamino)benzodiazepinones 3a,b with hydrazides yielded triazolobenzodiazepinones 4 which were treated with Lawesson's reagent to give thiolactams 5 . The phase-transfer catalyzed (TEBA) alkylation of compounds 5 with s
Publikováno v:
ChemInform. 22
Publikováno v:
ChemInform. 22
Publikováno v:
ChemInform. 23
Publikováno v:
ChemInform. 25