Zobrazeno 1 - 10
of 182
pro vyhledávání: '"M De Pablos"'
Autor:
Juan García-Revilla, Rocío Ruiz, Ana M. Espinosa-Oliva, Marti Santiago, Irene García-Domínguez, Lluís Camprubí-Ferrer, Sara Bachiller, Tomas Deierborg, Bertrand Joseph, Rocío M. de Pablos, José A. Rodríguez-Gómez, José Luis Venero
Publikováno v:
Cell Death and Disease, Vol 15, Iss 8, Pp 1-17 (2024)
Abstract Parkinson’s Disease (PD) is a progressive neurodegenerative disorder characterized by the loss of dopaminergic neurons in the Substantia nigra pars compacta (SNpc). Apoptosis is thought to play a critical role in the progression of PD, and
Externí odkaz:
https://doaj.org/article/5830f9192c8c4eeb8035fd4999643512
Autor:
Isaac Rosado-Sánchez, Inés Herrero-Fernández, Salvador Sobrino, Ana E. Carvajal, Miguel Genebat, Laura Tarancón-Díez, María Carmen Garcia-Guerrero, María Carmen Puertas, Rocío M. de Pablos, Rocío Ruiz, Javier Martinez-Picado, Manuel Leal, Yolanda M. Pacheco
Publikováno v:
Journal of Microbiology, Immunology and Infection, Vol 56, Iss 6, Pp 1129-1138 (2023)
Background: Blood OX40-expressing CD4 T-cells from antiretroviral (ART)-treated people living with HIV (PWH) were found to be enriched for clonally-expanded HIV sequences, hence contributing to the HIV reservoir. OX40-OX40L is also a checkpoint regul
Externí odkaz:
https://doaj.org/article/6a42bf8683cc4f4594a259ba027a4f58
Autor:
Juan García-Revilla, Antonio Boza-Serrano, Ana M. Espinosa-Oliva, Manuel Sarmiento Soto, Tomas Deierborg, Rocío Ruiz, Rocío M. de Pablos, Miguel Angel Burguillos, Jose L. Venero
Publikováno v:
Cell Death and Disease, Vol 13, Iss 7, Pp 1-11 (2022)
Abstract The advent of high-throughput single-cell transcriptomic analysis of microglia has revealed different phenotypes that are inherently associated with disease conditions. A common feature of some of these activated phenotypes is the upregulati
Externí odkaz:
https://doaj.org/article/76375f01088348f6b172a92d7d5af1f9
Autor:
Rocío Piñero-Pérez, Alejandra López-Cabrera, Mónica Álvarez-Córdoba, Paula Cilleros-Holgado, Marta Talaverón-Rey, Alejandra Suárez-Carrillo, Manuel Munuera-Cabeza, David Gómez-Fernández, Diana Reche-López, Ana Romero-González, José Manuel Romero-Domínguez, Rocío M. de Pablos, José A. Sánchez-Alcázar
Publikováno v:
Antioxidants, Vol 12, Iss 12, p 2023 (2023)
Nemaline myopathy (NM) is one of the most common forms of congenital myopathy and it is identified by the presence of “nemaline bodies” (rods) in muscle fibers by histopathological examination. The most common forms of NM are caused by mutations
Externí odkaz:
https://doaj.org/article/3f35ec582d594ef09dd5ac35e561212f
Autor:
I. Suárez-Pereira, I. García-Domínguez, L. Bravo, M. Santiago, J. García-Revilla, A. M. Espinosa-Oliva, I. M. Alonso-Bellido, C. López-Martín, E. M. Pérez-Villegas, J. A. Armengol, E. Berrocoso, J. L. Venero, R. M. de Pablos, R. Ruiz
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 10 (2022)
In the last decade, new non-apoptotic roles have been ascribed to apoptotic caspases. This family of proteins plays an important role in the sculpting of the brain in the early stages of development by eliminating excessive and nonfunctional synapses
Externí odkaz:
https://doaj.org/article/36e8ad09c5b848ca9a77299371b31f8a
Autor:
Ana M. Espinosa-Oliva, Pablo García-Miranda, Isabel María Alonso-Bellido, Ana E. Carvajal, Melania González-Rodríguez, Alejandro Carrillo-Jiménez, Arturo J. Temblador, Manuel Felices-Navarro, Irene García-Domínguez, María Angustias Roca-Ceballos, María D. Vázquez-Carretero, Juan García-Revilla, Marti Santiago, María J. Peral, José Luis Venero, Rocío M. de Pablos
Publikováno v:
Frontiers in Pharmacology, Vol 12 (2021)
Parkinson’s disease is a highly prevalent neurological disorder for which there is currently no cure. Therefore, the knowledge of risk factors as well as the development of new putative molecular targets is mandatory. In this sense, peripheral infl
Externí odkaz:
https://doaj.org/article/d1fc2af0ac2241a0a19c37ad805ef7b5
Autor:
Ana K Ibarrola-Vannucci, Luis M De Pablos, Lissette Retana-Moreira, Alberto Cornet-Gomez, Teresa Cruz-Bustos, Alejandro G Schijman, José L Ramírez, Susana Vílchez, Antonio Osuna
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 15, Iss 4, p e0009322 (2021)
BackgroundChagas disease is the third most important neglected tropical disease. There is no vaccine available, and only two drugs are generally prescribed for the treatment, both of which with a wide range of side effects. Our study of T. cruzi PHBs
Externí odkaz:
https://doaj.org/article/c3caafb8f9bc4889aaa484a3a8af039a
Autor:
Juan Carlos Fernández-Martín, Ana María Espinosa-Oliva, Irene García-Domínguez, Isaac Rosado-Sánchez, Yolanda M. Pacheco, Rosario Moyano, José G. Monterde, José Luis Venero, Rocío M. de Pablos
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 3, p 1170 (2022)
Lipopolysaccharide (LPS)-induced endotoxemia induces an acute systemic inflammatory response that mimics some important features of sepsis, the disease with the highest mortality rate worldwide. In this work, we have analyzed a murine model of endoto
Externí odkaz:
https://doaj.org/article/268d18d650db49e6944aee21e95a0025
Autor:
Irene García-Domínguez, Karolina Veselá, Juan García-Revilla, Alejandro Carrillo-Jiménez, María Angustias Roca-Ceballos, Marti Santiago, Rocío M. de Pablos, José L. Venero
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 12 (2018)
The impact of systemic inflammation in nigral dopaminergic cell loss remains unclear. Here, we have investigated the role of peripheral inflammation induced by systemic lipopolysaccharide (LPS) administration in the MPTP-based model of Parkinson’s
Externí odkaz:
https://doaj.org/article/eea619f87a7a4fb896ea30bddf7ad24f
Autor:
Khadija Tayara, Ana M. Espinosa-Oliva, Irene García-Domínguez, Afrah Abdul Ismaiel, Antonio Boza-Serrano, Tomas Deierborg, Alberto Machado, Antonio J. Herrera, José L. Venero, Rocío M. de Pablos
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 12 (2018)
The oral antidiabetic drug metformin is known to exhibit anti-inflammatory properties through activation of AMP kinase, thus protecting various brain tissues as cortical neurons, for example. However, the effect of metformin on the substantia nigra (
Externí odkaz:
https://doaj.org/article/12db5a065ee949e1a31d4d80433e4a2b