Zobrazeno 1 - 10
of 54
pro vyhledávání: '"M David Stewart"'
Autor:
Tara L Rasmussen, Yanlin Ma, Chong Yon Park, June Harriss, Stephanie A Pierce, Joseph D Dekker, Nicolas Valenzuela, Deepak Srivastava, Robert J Schwartz, M David Stewart, Haley O Tucker
Publikováno v:
PLoS ONE, Vol 10, Iss 3, p e0121765 (2015)
Smyd1/Bop is an evolutionary conserved histone methyltransferase previously shown by conventional knockout to be critical for embryonic heart development. To further explore the mechanism(s) in a cell autonomous context, we conditionally ablated Smyd
Externí odkaz:
https://doaj.org/article/6474b35f28774de6a4df747fea3aeed0
Autor:
M. David Stewart, Suhujey Lopez, Harika Nagandla, Benjamin Soibam, Ashley Benham, Jasmine Nguyen, Nicolas Valenzuela, Harry J. Wu, Alan R. Burns, Tara L. Rasmussen, Haley O. Tucker, Robert J. Schwartz
Publikováno v:
Disease Models & Mechanisms, Vol 9, Iss 3, Pp 347-359 (2016)
The Smyd1 gene encodes a lysine methyltransferase specifically expressed in striated muscle. Because Smyd1-null mouse embryos die from heart malformation prior to formation of skeletal muscle, we developed a Smyd1 conditional-knockout allele to deter
Externí odkaz:
https://doaj.org/article/7624d789c2964ec3942e5143c4307fb0
Autor:
M. David Stewart, Xin Wang, Fan Wang, Yinghong Ren, Raymond Saba, Zhi Tan, Benjamin Soibam, Anam Syed, Rui Liang, Robert J. Schwartz, Xiaopeng Shen, Yu Liu, Yoonjung Park, Bradley K. McConnell, Alex DesJarlais, Jin Yang, Shreesti Shrestha, Xuan Ji, Ashok Kumar, Fang Yu
Publikováno v:
Journal of Cachexia, Sarcopenia and Muscle, Vol 12, Iss 6, Pp 2174-2186 (2021)
Journal of Cachexia, Sarcopenia and Muscle
Journal of Cachexia, Sarcopenia and Muscle
Background Skeletal muscle atrophy is a debilitating complication of many chronic diseases, disuse conditions, and ageing. Genome‐wide gene expression analyses have identified that elevated levels of microRNAs encoded by the H19X locus are among th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c25aec77d5b0c266ed04b205024cf60e
https://doi.org/10.1002/jcsm.12827
https://doi.org/10.1002/jcsm.12827
Autor:
C Allison Stewart, M David Stewart, Ying Wang, Rachel D Mullen, Bonnie K Kircher, Rui Liang, Yu Liu, Richard R Behringer
Publikováno v:
Endocrinology
Female mice homozygous for an engineered Gnrhr E90K mutation have reduced gonadotropin-releasing hormone signaling, leading to infertility. Their ovaries have numerous antral follicles but no corpora lutea, indicating a block to ovulation. These muta
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d80c23dc76f3bf1eb15dd67d45cf3484
https://doi.org/10.1210/endocr/bqac011
https://doi.org/10.1210/endocr/bqac011
Autor:
M. David Stewart, Bradley K. McConnell, Corey L. Reynolds, Robert J. Schwartz, Suchi Raghunathan
Publikováno v:
Fundamental & Clinical Pharmacology. 33:25-30
Inbred mouse strains are the most widely used mammalian model organism in biomedical research owing to ease of genetic manipulation and short lifespan; however, each inbred strain possesses a unique repertoire of deleterious homozygous alleles that c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7537e042242f0b1305bcdc01eb59d640
https://doi.org/10.1111/fcp.12398
https://doi.org/10.1111/fcp.12398
Autor:
Jingliang Cheng, Luquan Yang, Junjiang Fu, Dianzheng Zhang, Shangyi Fu, Chunli Wei, Xiuli Xiao, M. David Stewart
Publikováno v:
Oncotarget
// Shangyi Fu 2, * , Jingliang Cheng 1, * , Chunli Wei 1, * , Luquan Yang 1 , Xiuli Xiao 3 , Dianzheng Zhang 4 , M. David Stewart 2, 5, 6 and Junjiang Fu 1, 7 1 Key Laboratory of Epigenetics and Oncology, the Research Center for Preclinical Medicine,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a5cedec656a3dee7a81ce539e633374a
http://europepmc.org/articles/PMC5546446
http://europepmc.org/articles/PMC5546446
Autor:
Matthew J. Roberston, M. David Stewart, Bradley K. McConnell, Vladimir N. Potaman, Robert J. Schwartz, Fan Zhang, Suchi Raghunathan
Publikováno v:
FASEB J
Muscle wasting, or muscle atrophy, can occur with age, injury, and disease; it affects the quality of life and complicates treatment. Insulin-like growth factor 1 (IGF1) is a key positive regulator of muscle mass. The IGF1/Igf1 gene encodes multiple
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::660960a1131ecc2d979a72a6d5a2472f
https://pubmed.ncbi.nlm.nih.gov/31914652
https://pubmed.ncbi.nlm.nih.gov/31914652
Autor:
Bradley K. McConnell, Yu Liu, Qiying Fan, Nicolas Valenzuela, Robert J. Schwartz, Harika Nagandla, M. David Stewart, Faisal Fa’ak, Benjamin Soibam
Publikováno v:
Disease Models & Mechanisms, Vol 9, Iss 3, Pp 335-345 (2016)
Disease Models & Mechanisms
Disease Models & Mechanisms
HIRA is the histone chaperone responsible for replication-independent incorporation of histone variant H3.3 within gene bodies and regulatory regions of actively transcribed genes, and within the bivalent promoter regions of developmentally regulated
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::362d4758c10799156694af3bc239f85a
https://doi.org/10.1242/dmm.022889
https://doi.org/10.1242/dmm.022889
Autor:
Wei Yu, Haley O. Tucker, Tara L. Rasmussen, Harika Nagandla, Robert J. Schwartz, M. David Stewart, Suhujey Lopez
Publikováno v:
Developmental Biology. 410:86-97
The SMYD (SET and MYND domain) family of lysine methyltransferases harbor a unique structure in which the methyltransferase (SET) domain is intervened by a zinc finger protein–protein interaction MYND domain. SMYD proteins methylate both histone an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::557d61776e33ebb98126c616a8584dfb
https://doi.org/10.1016/j.ydbio.2015.12.005
https://doi.org/10.1016/j.ydbio.2015.12.005
Female mice homozygous for an engineered Gnrhr E90K mutation have reduced gonadotropin-releasing hormone signaling, leading to infertility. Their ovaries have numerous antral follicles but no corpora lutea, indicating a block to ovulation. These muta
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0afcf4b4b5ad2cbd6f3465a502580055
https://doi.org/10.1101/347757
https://doi.org/10.1101/347757
