Zobrazeno 1 - 10
of 20
pro vyhledávání: '"M David, Weingarten"'
Autor:
Shana K. Cyr, M. David Weingarten
Publikováno v:
ACS Med Chem Lett
[Image: see text] Pharmaceutical companies may recoup the investment necessary to discover, develop, and obtain market approval for a new pharmaceutical product by securing and maintaining a strong patent portfolio. To maximize patent protection and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8fc7f4efca37e4266ade33b5a3323b74
https://europepmc.org/articles/PMC6580373/
https://europepmc.org/articles/PMC6580373/
Autor:
Zhihong Ye, Charles Q. Meng, Kimberly J. Worsencroft, James A. Sikorski, Randy B. Howard, Ki-Ling Suen, Martin A. Wasserman, Liming Ni, Jason W. Skudlarek, Jacob E. Simpson, Cynthia L. Sundell, Charles A. Kunsch, Amy Souder, M. David Weingarten, Elaine M. Marino
Publikováno v:
Journal of Medicinal Chemistry. 50:1304-1315
Starting from a simple chalcone template, structure-activity relationship (SAR) studies led to a series of carboxylated, heteroaryl-substituted chalcone derivatives as novel, potent inhibitors of vascular cell adhesion molecule-1 (VCAM-1) expression.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5756878f29e82e8d43f25c4437d306cc
https://doi.org/10.1021/jm0614230
https://doi.org/10.1021/jm0614230
Autor:
John Y. L. Chung, Louis Matty, George Zhou, Fuh-Rong Tsay, Michael H. Kress, Raymond Cvetovich, M. David Weingarten, Joseph S. Amato, Zhen Li
Publikováno v:
The Journal of Organic Chemistry. 70:8560-8563
A practical synthesis of benzisoxazole 1 and its conversion to α-aryloxyisobutyric acid 2 using 1,1,1-trichloro-2-methyl-2-propanol (chloretone) was developed. Benzisoxazole 1 was formed in high yields by the action of either methanesulfonyl chlorid
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d1a505976b09bb9fdf22644c4ee1c993
https://doi.org/10.1021/jo051027+
https://doi.org/10.1021/jo051027+
Discovery of novel heteroaryl-substituted chalcones as inhibitors of TNF-α-induced VCAM-1 expression
Autor:
Jason W. Skudlarek, Martin A. Wasserman, Jacob E. Simpson, James A. Sikorski, Liming Ni, Kimberly J. Worsencroft, Hotema Martha R, Ki-Ling Suen, X.Sharon Zheng, Charles A. Kunsch, Zhihong Ye, Russell R. Hill, Elaine M. Marino, Lee K. Hoong, M. David Weingarten, Joshua M. Gilmore, Charles Q. Meng
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 14:1513-1517
Novel chalcone derivatives have been discovered as potent inhibitors of TNF-α-induced VCAM-1 expression. Thienyl or benzothienyl substitution at the meta-position of ring B helps boost potency while large substitution at the para-position on ring B
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6fccac86680b3969958f87939056d433
https://doi.org/10.1016/j.bmcl.2004.01.021
https://doi.org/10.1016/j.bmcl.2004.01.021
Autor:
M. David Weingarten, Dennis W. P. M. Löwik, Arwin J. Brouwer, Rob M. J. Liskamp, W. Clark Still, Matthias Broekema
Publikováno v:
Angewandte Chemie. 110:1947-1950
Unter Erhaltung der Selektivitat kann durch Variation der Gelenkgruppe eines pinzettenartigen Rezeptors eine hohere Affinitat erzielt werden. So bindet der synthetische Peptidosulfonamid-Rezeptor (unten links; R=Disperse-Rot 1) mit dem Bis(aminomethy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::788d15811663d289f5aeffe63bb47a8d
https://doi.org/10.1002/(sici)1521-3757(19980703)110:13/14<1947::aid-ange1947>3.0.co
https://doi.org/10.1002/(sici)1521-3757(19980703)110:13/14<1947::aid-ange1947>3.0.co
Publikováno v:
The Journal of Organic Chemistry. 62:2001-2010
A series of diazoamido keto esters were prepared by the reaction of N-substituted 3-carbethoxy-2-piperidone with n-butylmagnesium chloride followed by the addition of ethyl 2-diazomalonyl chloride. Treatment of these diazo amides with rhodium(II) ace
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7fee61f36a374f069f2a208530f30c11
https://doi.org/10.1021/jo962184z
https://doi.org/10.1021/jo962184z
Publikováno v:
Tetrahedron. 53:2371-2386
Ethyl (trialkylstannyl)diazoacetates have been employed as substrates in the Stille reaction. The palladium(0)-catalyzed cross coupling works well with aryl iodides but not with acyl or aryl chlorides. Bis -[ethoxycarbonyl-diazomethyl]-mercury showed
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7aa07b2a93a145c07df77579431b00d4
https://doi.org/10.1016/s0040-4020(96)01194-5
https://doi.org/10.1016/s0040-4020(96)01194-5
Publikováno v:
The Journal of Organic Chemistry. 60:5595-5603
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7c508cbbd1a83ff27273dc6433ff08be
https://doi.org/10.1021/jo00122a047
https://doi.org/10.1021/jo00122a047
Publikováno v:
The Journal of Organic Chemistry. 60:53-62
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::07320c776c18180b95752fa6ff89ba31
https://doi.org/10.1021/jo00106a014
https://doi.org/10.1021/jo00106a014
Publikováno v:
Tetrahedron Letters. 34:7853-7856
A new annulation sequence leading to oxabicyclic ring systems is effected by treating o-alkynyl substituted α-diazoacetophenones containing tethered carbonyl groups with Rh(II) carboxylates in the presence of CC π-bonds.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::004aa8472d468da62828aa4e5b41d810
https://doi.org/10.1016/s0040-4039(00)61493-4
https://doi.org/10.1016/s0040-4039(00)61493-4