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Akademický článek

Peptoid-based macrodiscs of variable lipid composition for structural studies of membrane proteins by oriented-sample solid-state NMR

Autor: Azamat R. Galiakhmetov, Adit A. Shah, Addison Lane, Carolynn M. Davern, Caroline Proulx, Alexander A. Nevzorov

Publikováno v: Journal of Structural Biology: X, Vol 9, Iss , Pp 100095- (2024)

Solid-state Nuclear Magnetic Resonance (NMR) in combination with magnetically aligned discoidal lipid mimics allows for studying the conformations of membrane proteins in planar, lipid-rich bilayer environments and at the physiological temperature. W

Externí odkaz: https://doaj.org/article/38b3098d271b49aa86a05a72d44afe35

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Akademický článek

Detection and quantification of γ-H2AX using a dissociation enhanced lanthanide fluorescence immunoassay

Autor: Felicite K. Noubissi, Amber A. McBride, Hannah G. Leppert, Larry J. Millet, Xiaofei Wang, Sandra M. Davern

Publikováno v: Scientific Reports, Vol 11, Iss 1, Pp 1-12 (2021)

Abstract Phosphorylation of the histone protein H2AX to form γ-H2AX foci directly represents DNA double-strand break formation. Traditional γ-H2AX detection involves counting individual foci within individual nuclei. The novelty of this work is the

Externí odkaz: https://doaj.org/article/b318484cefd641de873ac56966a7f9c7

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Akademický článek

Identifying Candidate Biomarkers of Ionizing Radiation in Human Pulmonary Microvascular Lumens Using Microfluidics—A Pilot Study

Autor: Larry J. Millet, Richard J. Giannone, Michael S. Greenwood, Carmen M. Foster, Kathleen M. O’Neil, Alexander D. Braatz, Sandra M. Davern

Publikováno v: Micromachines, Vol 12, Iss 8, p 904 (2021)

The microvasculature system is critical for the delivery and removal of key nutrients and waste products and is significantly damaged by ionizing radiation. Single-cell capillaries and microvasculature structures are the primary cause of circulatory

Externí odkaz: https://doaj.org/article/47be94ec8f6940b1b64693ad80f3e0f2

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Akademický článek

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Review

Places for People: Hotels, Motels, Restaurants, Bars, Clubs, Community Recreation Facilities, Camps, Parks, Plazas and Playgrounds, An Architectural Record Book Jeanne M. Davern Jan V. White

Autor: Bender, Richard

Publikováno v: Journal of the Society of Architectural Historians, 1977 Dec 01. 36(4), 273-273.

Externí odkaz: https://www.jstor.org/stable/989298

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P09.07 Novel insights into immune-independent functions of immune checkpoint inhibitors in oesophageal adenocarcinoma; potential implications for designing combination immuno-chemotherapy regimens to achieve synergistic responses

Autor: M Davern, C Buckley, C Fitzgerald, AB Heeran, NE Donlon, J McGrath, R O’ Brien, F O’ Connell, B Murphy, N Lynam-Lennon, JV Reynolds, SG Maher, AD Sheppard, A Bhardwaj, C Butler, N Ravi, J Lysaght

Publikováno v: Poster Presentations.

Background Immune checkpoint inhibitors (ICIs) reinvigorate anti-tumour immunity in oesophageal adenocarcinoma (OAC). However, emerging studies have identified novel immune-independent functions for immune checkpoints (ICs) in other solid tumour-type

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::c35235016f5eb71009514b1273e5e858
https://doi.org/10.1136/jitc-2021-itoc8.57

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Tailoring the Radionuclide Encapsulation and Surface Chemistry of La(223Ra)VO4 Nanoparticles for Targeted Alpha Therapy

Autor: Roy Copping, David A. Cullen, Saed Mirzadeh, Allison Peacock, Andrew Miskowiec, Miguel Toro-González, Sandra M. Davern

Publikováno v: Journal of Nanotheranostics
Volume 2
Issue 1
Pages 3-50

The development of targeted alpha therapy (TAT) as a viable cancer treatment requires innovative solutions to challenges associated with radionuclide retention to enhance local tumor cytotoxicity and to minimize off-target effects. Nanoparticles (NPs

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::44c0f42af14d9add0adafc8303edc47c
https://doi.org/10.3390/jnt2010003

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Submonomer synthesis of peptoids containing trans-inducing N-imino- and N-alkylamino-glycines

Autor: Carolynn M. Davern, Brandon D. Lowe, Elon A. Ison, Adam Rosfi, Caroline Proulx

Publikováno v: Chemical Science

The use of hydrazones as a new type of submonomer in peptoid synthesis is described, giving access to peptoid monomers that are structure-inducing. A wide range of hydrazones were found to readily react with α-bromoamides in routine solid phase pept

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4bc8a531cefbec37169e5abd6f8159f3
https://doi.org/10.1039/d1sc00717c

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