Zobrazeno 1 - 10
of 69
pro vyhledávání: '"M D Siperstein"'
Publikováno v:
Journal of Lipid Research, Vol 27, Iss 10, Pp 1044-1051 (1990)
The cause of the hypercholesterolemia that characterizes the nephrotic syndrome has never been adequately explained. The present study examines the possibility that enhanced availability of the cholesterol precursor, mevalonic acid, to the liver in t
Externí odkaz:
https://doaj.org/article/96577f261f4d43f9a8673bbee0e7d815
Publikováno v:
Journal of Lipid Research, Vol 16, Iss 5, Pp 360-366 (1975)
The level of cholesterol synthesis and the activity of the cholesterol feedback system were studied in tissue slices from a number of organs of the guinea pig. In contrast to the tissue distribution of sterol synthesis in the rat, liver slices of the
Externí odkaz:
https://doaj.org/article/b80ec541cebf4d87a6026df0ab0e9579
Publikováno v:
Journal of Lipid Research, Vol 22, Iss 6, Pp 990-997 (1981)
Circulating mevalonate is metabolized by two mechanisms: the sterol pathways leading to cholesterol and the shunt pathway resulting in CO2 production. The kidney is the chief site of circulating mevalonate metabolism by both pathways. The present stu
Externí odkaz:
https://doaj.org/article/b5b2ebe77d07402392efecec5a213c1e
Publikováno v:
Journal of Lipid Research, Vol 24, Iss 3, Pp 290-296 (1983)
HMG-CoA reductase activity can be modulated by a reversible phosphorylation-dephosphorylation with the phosphorylated form of the enzyme being inactive and the dephosphorylated form, active. Phosphatases from diverse sources, including cytosol, have
Externí odkaz:
https://doaj.org/article/dba227b37619473aa49c35fea2641193
Autor:
M D Siperstein
Publikováno v:
Journal of Lipid Research, Vol 25, Iss 13, Pp 1462-1468 (1984)
In summary, there is now ample evidence that cell growth, as well as DNA replication, is closely linked to cholesterogenesis in a manner that has only recently been appreciated. Mevalonic acid, the product of HMG-CoA reductase, the rate-limiting enzy
Externí odkaz:
https://doaj.org/article/619bbfebc1c44340af3486cb8f5baef2
Publikováno v:
Biochemical Journal. 288:883-889
We have investigated the biochemical basis of the mevalonate dependence of DNA replication. Stimulating quiescent rat hepatoma cells to proliferate in the presence of compactin, an inhibitor of mevalonate synthesis, prevented DNA replication in as ma
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bc79438f7b534c37a32a94f935407254
https://doi.org/10.1042/bj2880883
https://doi.org/10.1042/bj2880883
Autor:
M D, Siperstein
Publikováno v:
Advances in experimental medicine and biology. 369
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::d822ee2d3bae9fa9d2f51c49a4a6ec51
https://pubmed.ncbi.nlm.nih.gov/7598003
https://pubmed.ncbi.nlm.nih.gov/7598003
Autor:
M D, Siperstein
Publikováno v:
Endocrinology and metabolism clinics of North America. 21(2)
DKA-hyperosmolar coma is a readily diagnosed and easily treated, potentially catastrophic emergency that regularly occurs in both Type I and Type II diabetics. This review emphasized that diabetic ketoacidosis and hyperosmolar coma can, and very freq
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::a370b4f7ccaee8d3110bce88d32a2242
https://pubmed.ncbi.nlm.nih.gov/1612073
https://pubmed.ncbi.nlm.nih.gov/1612073
Autor:
Eva Tsalikian, Mara Lorenzi, M D Siperstein, M Rosenthal, John H. Karam, John E. Gerich, Peter H. Forsham, J J O'Donnell
Publikováno v:
Diabetes. 25:24-28
In a pair of 19-year-old monozygotic twin girls, one developed insulin-dependent, ketosis-prone diabetes at the age of three and has required insulin for the past 16 years. Her identical twin has maintained normal oral and intravenous glucose toleran
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2e9e73d9fa0d141fa8cae7c1fb5b18f4
https://doi.org/10.2337/diabetes.25.1.24
https://doi.org/10.2337/diabetes.25.1.24
Publikováno v:
Journal of Biological Chemistry. 251:2716-2721
The metabolism of mevalonic acid by both sterol and non-sterol pathways has been evaluated in nine tissues of the rat. An in vitro estimation of the non-sterol, or "shunt", pathway of mevalonate metabolism was made possible by determining the convers
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f6d62c985d06664739a5da1b1389c1b1
https://doi.org/10.1016/s0021-9258(17)33546-9
https://doi.org/10.1016/s0021-9258(17)33546-9