Zobrazeno 1 - 10
of 58
pro vyhledávání: '"M D Scharff"'
Publikováno v:
Journal of Molecular Biology. 261:11-22
Cryptococcus neoformans is an encapsulated fungus that causes a life-threatening meningoencephalitis in patients with AIDS. Monoclonal antibodies to the capsular glucuronoxylomannan can modulate the infection in mice, but the epitopes on this complex
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::57d767d61a88cd92a5b53314e609f88e
https://doi.org/10.1006/jmbi.1996.0438
https://doi.org/10.1006/jmbi.1996.0438
Publikováno v:
The Journal of Immunology. 154:1810-1816
Passively administered mAbs to Cryptococcus neoformans capsular polysaccharide can alter the course of infection in mouse models. In preliminary studies of passive Ab efficacy, most IgM, IgA, and IgG1 mAbs were protective, but the few IgG3 mAbs teste
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5bab4c046000528e25f2cb78095d4cb6
https://doi.org/10.4049/jimmunol.154.4.1810
https://doi.org/10.4049/jimmunol.154.4.1810
Autor:
S L Zebedee, R K Koduri, Arturo Casadevall, Sushovita Mukherjee, D F Sauer, M D Scharff, Jean Mukherjee, Sunhee Lee
Publikováno v:
Antimicrobial Agents and Chemotherapy. 38:1507-1514
Passive antibody administration is a potentially useful approach for the therapy of human Cryptococcus neoformans infections. To evaluate the efficacy of the human immunoglobulin G1 (IgG1) constant region against C. neoformans and to construct murine
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a1c563649374b95a5c73d0c7812f5889
https://doi.org/10.1128/aac.38.7.1507
https://doi.org/10.1128/aac.38.7.1507
Autor:
Jean Mukherjee, John B. Robbins, Rachel Schneerson, Arturo Casadevall, Sarvamangala J. N. Devi, M D Scharff
Publikováno v:
The Journal of Infectious Diseases. 165:1086-1093
The antibody responses of BALB/c mice to serotype A Cryptococcus neoformans capsular polysaccharide (CNPS) were compared after cryptococcal infection and immunization with a serotype A glucuronoxylomannan-tetanus toxoid conjugate (GXM-TT). Infection
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::28956e3ac7d133a714239a8d5fa9f4f3
https://doi.org/10.1093/infdis/165.6.1086
https://doi.org/10.1093/infdis/165.6.1086
Publikováno v:
The Journal of Immunology. 146:2010-2016
Mutant mAb with increased Ag binding were generated from a hybridoma cell line, 36-65, that secretes an IgG1,kappa anti-p-azophenylarsonate-(Ars) specific antibody. The mutant antibodies were identified using an Ars-specific ELISA and sib selection s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ac7d036f4ceeff432ddc455cc91cb4f6
https://doi.org/10.4049/jimmunol.146.6.2010
https://doi.org/10.4049/jimmunol.146.6.2010
Publikováno v:
The Journal of Immunology. 146:2017-2020
A V region mutant producing an antibody that had lost the ability to bind phosphocholine was isolated from a hybridoma producing a germline encoded T15 antibody. The mutation resulted in a single aspartic acid to asparagine substitution at residue 95
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e82382feeca23c56a56cba18b608b359
https://doi.org/10.4049/jimmunol.146.6.2017
https://doi.org/10.4049/jimmunol.146.6.2017
Publikováno v:
BioEssays : news and reviews in molecular, cellular and developmental biology. 20(3)
In the course of an immune response, antibodies undergo affinity maturation in order to increase their efficiency in neutralizing foreign invaders. Affinity maturation occurs by the introduction of multiple point mutations in the variable region gene
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::fe23d4d77893876f849ef992e9442ae9
https://pubmed.ncbi.nlm.nih.gov/9631650
https://pubmed.ncbi.nlm.nih.gov/9631650
Publikováno v:
The EMBO journal. 15(11)
We have established B cell culture systems in which transfected and stably integrated Ig constructs spontaneously undergo high rates of variable (V) region mutation. Mutation rates were determined using reversion analysis of an Ig V region nonsense c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::08703d787e7105c417bfbaaa31b2213d
https://pubmed.ncbi.nlm.nih.gov/8654371
https://pubmed.ncbi.nlm.nih.gov/8654371
Publikováno v:
Journal of immunology (Baltimore, Md. : 1950). 154(4)
Passively administered mAbs to Cryptococcus neoformans capsular polysaccharide can alter the course of infection in mouse models. In preliminary studies of passive Ab efficacy, most IgM, IgA, and IgG1 mAbs were protective, but the few IgG3 mAbs teste
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::ddabe2adc613f8e7da0b19f4906e6dd6
https://pubmed.ncbi.nlm.nih.gov/7836766
https://pubmed.ncbi.nlm.nih.gov/7836766
Publikováno v:
Cancer. 73
Although the four human immunoglobulin G (IgG) isotypes are similar in structure, they exhibit significant differences in effector function and catabolic half-life. With advent of structurally engineered antibodies, there is the potential to design a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::46b4bca85b454157924b634675a3ed51
https://pubmed.ncbi.nlm.nih.gov/8306262
https://pubmed.ncbi.nlm.nih.gov/8306262