Zobrazeno 1 - 10
of 81
pro vyhledávání: '"M D Meglasson"'
Publikováno v:
Bioscience Reports. 21:653-666
In rat islets, progesterone caused a prompt concentration-dependent inhibition of glucose-stimulated insulin release with an IC50 of 10 μM at 8.4 mM glucose. The inhibition was specific since both testosterone and 17β-estradiol had no such effect.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::18690b4dffd3a45f7974077826ed33af
https://doi.org/10.1023/a:1014773010350
https://doi.org/10.1023/a:1014773010350
Publikováno v:
Diabetes. 44:984-991
The role of insulin resistance in the impaired glucosestimulated insulin release of Zucker fatty rats was investigated using the insulin-sensitizing thiazolidinedione drug pioglitazone. Fatty rats had fasting hyperinsulinemia yet a blunted secretory
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::729e7b50495db0ce8739f5d599ff7444
https://doi.org/10.2337/diab.44.8.984
https://doi.org/10.2337/diab.44.8.984
Publikováno v:
Diabetes. 43:204-211
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7b987e3efd0473dbb98afa3988324fed
https://doi.org/10.2337/diabetes.43.2.204
https://doi.org/10.2337/diabetes.43.2.204
Publikováno v:
American Journal of Physiology-Endocrinology and Metabolism. 259:E216-E224
The characteristics of somatostatin (SRIF) receptors in rat pancreatic beta-cells were investigated using rat islets and the beta-cell line HIT-T15 (HIT). The biochemical properties of the SRIF receptors were examined with 125I-labeled des-Ala-1,Gly-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::539458bedf34032dec4c0b18d799ac48
https://doi.org/10.1152/ajpendo.1990.259.2.e216
https://doi.org/10.1152/ajpendo.1990.259.2.e216
Autor:
J E Burr, Scott D. Larsen, Paul D. May, Steven P. Tanis, F C Stevens, Michele M. Cudahy, J H Yu, John A. Tucker, M D Meglasson, V A Vaillancourt, Thomas J. Vidmar, M A Connell, D D Robinson, P V Fisher, B R Evans
Publikováno v:
Journal of medicinal chemistry. 44(8)
3-Guanidinopropionic acid (1) has been demonstrated both to improve insulin sensitivity and to promote weight loss selectively from adipose tissue in animal models of non-insulin-dependent diabetes mellitus (NIDDM). However, 1 has also been shown to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3fc99ed8c7655ca2625a9c74ec2d0c03
https://pubmed.ncbi.nlm.nih.gov/11312923
https://pubmed.ncbi.nlm.nih.gov/11312923
Autor:
W. Watt, Theresa J. O’Sullivan, Steven P. Tanis, J C Sih, J H Yu, Valerie A. Vaillancourt, M A Connell, Heinrich J. Schostarez, John A. Tucker, Thomas J. Vidmar, M D Meglasson, Michele M. Cudahy, C M Tegley, Scott D. Larsen, F C Stevens, Paul D. May, B R Evans
Publikováno v:
Journal of medicinal chemistry. 44(8)
3-Guanidinopropionic acid (1, PNU-10483) has been demonstrated to both improve insulin sensitivity and to promote weight loss selectively from adipose tissue in animal models of non-insulin-dependent diabetes mellitus (NIDDM). However, 1 has also bee
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::86a34af10b390522d35c0dea310dcc92
https://pubmed.ncbi.nlm.nih.gov/11312922
https://pubmed.ncbi.nlm.nih.gov/11312922
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 266(3)
To evaluate the long-held concept that acidic guanidines lack glycemic effects, guanidinoalkanoic acids and the biguanide metformin (positive control) were administered to KKAy mice, a model of noninsulin-dependent diabetes. Two acidic guanidines, 3-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::8c71e07096ec1b7ced6dd46a60fa5f8e
https://pubmed.ncbi.nlm.nih.gov/8371149
https://pubmed.ncbi.nlm.nih.gov/8371149
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 264(1)
To investigate the effect of calcium channel blockade on intracellular energy levels and stimulated insulin secretion in isolated rat pancreatic islets, five different blockers of calcium channels were used. Insulin secretion stimulated with 16 mM gl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::515a1739cc0397e56fd2c9093934059d
https://pubmed.ncbi.nlm.nih.gov/8423537
https://pubmed.ncbi.nlm.nih.gov/8423537
Publikováno v:
Biochemical pharmacology. 43(8)
Perifusion of islets with nominally phosphate-free buffer containing increasing concentrations of 2-deoxy-D-glucose (2.5 to 10 mM) produced increments in high alpha-ketoisocaproic acid-induced secretion of insulin beyond those observed in the absence
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::04e81b559327fceb5cbc6952bf7d0a56
https://pubmed.ncbi.nlm.nih.gov/1575778
https://pubmed.ncbi.nlm.nih.gov/1575778
Publikováno v:
Biochemical pharmacology. 42(3)
To define better the role of [ATP]/[ADP] in insulin release from pancreatic islets, changes in the adenine nucleotide ratios elicited by alterations in external pH were correlated with the secretion profiles produced by administration of two metaboli
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::de658f6bb5b3f3509d035aae4ffc6a47
https://pubmed.ncbi.nlm.nih.gov/1859465
https://pubmed.ncbi.nlm.nih.gov/1859465