Zobrazeno 1 - 10
of 84
pro vyhledávání: '"M D Hollenberg"'
Autor:
B I Posner, M Vranic, R B Haynes, R. J. de Souza, A R Ronald, David J.A. Jenkins, Laura Chiavaroli, Cyril W.C. Kendall, P Gold, Arash Mirrahimi, Effie Viguiliouk, John L. Sievenpiper, T M Chang, Tom Tsirakis, Kristie Srichaikul, Viranda H. Jayalath, Sathish C. Pichika, Andres M. Lozano, Y T Wang, Stephanie K. Nishi, Vivian L Choo, C Gillett, M D Hollenberg, Charles N. Bernstein
Publikováno v:
QJM: An International Journal of Medicine
Summary Background Perhaps, as never before, we need innovators. With our growing population numbers, and with increasing pressures on our education systems, are we in danger of becoming more rigid and formulaic and increasingly inhibiting innovation
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::75bcd7005b43cdf18285e34bcfb76951
https://doi.org/10.1093/qjmed/hcaa210
https://doi.org/10.1093/qjmed/hcaa210
Publikováno v:
British journal of pharmacology. 171(5)
Although it has been known since the 1960s that trypsin and chymotrypsin can mimic hormone action in tissues, it took until the 1990s to discover that serine proteinases can regulate cells by cleaving and activating a unique four-member family of GPC
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::bf2f1047bbd33f111e2f7e85f2478aac
https://pubmed.ncbi.nlm.nih.gov/24354792
https://pubmed.ncbi.nlm.nih.gov/24354792
Publikováno v:
American Journal of Physiology-Regulatory, Integrative and Comparative Physiology. 270:R1065-R1072
The receptor binding and biological activity of epidermal growth factor-urogastrone (EGF) was characterized in the follicle-enclosed goldfish oocyte. The binding of 125I-labeled mouse EGF (mEGF) to goldfish ovarian membrane preparation was peptide sp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1044618a67d40c3e36ce3e370f81ae0a
https://doi.org/10.1152/ajpregu.1996.270.5.r1065
https://doi.org/10.1152/ajpregu.1996.270.5.r1065
Publikováno v:
British journal of pharmacology. 167(8)
The PAR(2) receptors are involved in chronic arthritis by mechanisms that are as yet unclear. Here, we examined PAR(2) activation in the rat knee joint.PAR(2) in rat knee joint dorsal root ganglia (DRG) cells at L3-L5, retrogradely labelled with Fluo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::67cc74742e66c434d1e383e8cc1cf2e9
https://pubmed.ncbi.nlm.nih.gov/22849826
https://pubmed.ncbi.nlm.nih.gov/22849826
Autor:
Y, Li, K, Mihara, M, Saifeddine, A, Krawetz, D C W, Lau, H, Li, H, Ding, C R, Triggle, M D, Hollenberg
Publikováno v:
British journal of pharmacology. 164(8)
We hypothesized that proteinase-activated receptor-2 (PAR2)-mediated vasorelaxation in murine aorta tissue can be due in part to the release of adipocyte-derived relaxing factors (ADRFs).Aortic rings from obese TallyHo and C57Bl6 intact or PAR2-null
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::eb63450f8d60e651fcc463dfb2b104da
https://pubmed.ncbi.nlm.nih.gov/21615723
https://pubmed.ncbi.nlm.nih.gov/21615723
Autor:
R, Ramachandran, M D, Hollenberg
Publikováno v:
British journal of pharmacology. 153
Proteinases like thrombin, trypsin and tissue kallikreins are now known to regulate cell signaling by cleaving and activating a novel family of G-protein-coupled proteinase-activated receptors (PARs 1–4) via exposure of a tethered receptor-triggeri
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::68649f9c1aabf37378b7f492f11f5d1d
https://pubmed.ncbi.nlm.nih.gov/18059329
https://pubmed.ncbi.nlm.nih.gov/18059329
Publikováno v:
British journal of pharmacology. 134(4)
Endostatin is a potent endogenous inhibitor of angiogenesis that was recently shown to be stored in platelets and released in response to thrombin, but not ADP. In the present study, we have tested the hypothesis that thrombin-induced endostatin rele
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::05d1d13bdbc8bc6c758ad5cbb584d94e
https://pubmed.ncbi.nlm.nih.gov/11606309
https://pubmed.ncbi.nlm.nih.gov/11606309
Autor:
L, de Garavilla, N, Vergnolle, S H, Young, H, Ennes, M, Steinhoff, V S, Ossovskaya, M R, D'Andrea, E A, Mayer, J L, Wallace, M D, Hollenberg, P, Andrade-Gordon, N W, Bunnett
Publikováno v:
British journal of pharmacology. 133(7)
Thrombin, generated in the circulation during injury, cleaves proteinase-activated receptor 1 (PAR1) to stimulate plasma extravasation and granulocyte infiltration. However, the mechanism of thrombin-induced inflammation in intact tissues is unknown.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::9905ab83c5a659fd0ae47427b411d93f
https://pubmed.ncbi.nlm.nih.gov/11487506
https://pubmed.ncbi.nlm.nih.gov/11487506
Autor:
M D, Hollenberg, M, Saifeddine
Publikováno v:
Canadian journal of physiology and pharmacology. 79(5)
We studied the actions of receptor-activating peptide analogues (PAR4APs), modeled on the proteolytically-revealed tethered ligand sequence of murine proteinase-activated receptor-4 (PAR4), in a rat platelet aggregation assay. The PAR4APs GYPGKF-NH2
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::be3fe4d17f0c9ec5387c49336431dceb
https://pubmed.ncbi.nlm.nih.gov/11405248
https://pubmed.ncbi.nlm.nih.gov/11405248
Publikováno v:
Canadian journal of physiology and pharmacology. 78(1)
The neuronal growth associated protein B-50/GAP-43 has been localized in synaptosomes both as an intact protein and as a partial proteolysis product (termed B-60) that has an N-terminal sequence SFRGHITR.... Because of the relationship of this amino
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::20d2267498aab7cec1f543704193b374
https://pubmed.ncbi.nlm.nih.gov/10741764
https://pubmed.ncbi.nlm.nih.gov/10741764