Zobrazeno 1 - 10
of 33
pro vyhledávání: '"M D, Smirnov"'
Publikováno v:
Biochemistry. 38:3591-3598
The phospholipid composition requirements for optimal prothrombin activation and factor Va inactivation by activated protein C (APC) anticoagulant were examined. Vesicles composed of phosphatidylethanolamine (PE) and phosphatidylcholine (PC) supporte
Autor:
M D Smirnov, Charles T. Esmon, Ankur Joshi, Aron B. Fisher, Vladimir R. Muzykantov, Naomi L. Esmon, Irina V. Balyasnikova
Publikováno v:
Drug Delivery. 5:197-206
Internalization of antibodies to thrombomodulin (TM) may provide a mechanism for intraendothelial targeting of drugs or genes. This study characterized three monoclonal antibodies against human TM (mAb 1009,1029, and 1045) and examined their internal
Publikováno v:
Blood. 78:2611-2618
Noncovalent attachment of avidin to the membrane of prebiotinylated red blood cells (RBCs) induces lysis via the alternative pathway of complement (APC). Lysis is not species-dependent; RBCs from humans, rabbits, rats, and sheep were lysed with both
Publikováno v:
Biochemical Journal. 273:393-397
Non-covalent binding of avidin to biotinylated erythrocytes results in complement-dependent haemolysis. Biotinylated erythrocytes, as well as native cells, are not lysed by complement. Complement activation requires a tight contact between avidin and
Publikováno v:
Chinese medical journal. 114(4)
To investigate the factor V Leiden mutation associated with activated protein C resistance (APCR) in Chinese.Thirty "normal" individuals and twenty patients with thrombotic disease from Chinese Han Nationality were studied with APTT +/- APC, PCR foll
Publikováno v:
Blood. 94(11)
In this study, we test the hypothesis that prothrombin levels may modulate activated protein C (APC) anticoagulant activity. Prothrombin in purified systems or plasma dramatically inhibited the ability of APC to inactivate factor Va and to anticoagul
Publikováno v:
Haematologica. 84(5)
Although lupus anticoagulants (LAs) are immunoglobulins that inhibit procoagulant reactions in vitro, these molecules are associated with thrombosis in vivo. We and others have hypothesized that this may be due to selective targeting of the activated
Publikováno v:
The Journal of biological chemistry. 274(9)
The effect of replacing the gamma-carboxyglutamic acid domain of activated protein C (APC) with that of prothrombin on the topography of the membrane-bound enzyme was examined using fluorescence resonance energy transfer. The average distance of clos
Publikováno v:
Thrombosis and haemostasis. 78(1)
These studies indicate how immunoglobulin populations that react with phospholipid surfaces in the absence of other cofactor molecules can selectively inhibit anticoagulant pathways and lead to a prothrombotic state. These studies combined with those
Autor:
M D, Smirnov
Publikováno v:
Vestnik rentgenologii i radiologii. (1)
X-Ray examination of 85 patients (63 with sternal osteomyelitis) carried out to plan a surgical intervention should be based on a complex of special methods including roentgenography in the lateral projection, spot roentgenography in oblique projecti