Výsledky vyhledávání - "M D, Ribadeneira"

Design and synthesis of a series of (2R)-N(4)-hydroxy-2-(3-hydroxybenzyl)-N(1)- [(1S,2R)-2-hydroxy-2,3-dihydro-1H-inden-1-yl]butanediamide derivatives as potent, selective, and orally bioavailable aggrecanase inhibitors

Autor: W, Yao, Z R, Wasserman, M, Chao, G, Reddy, E, Shi, R Q, Liu, M B, Covington, E C, Arner, M A, Pratta, M, Tortorella, R L, Magolda, R, Newton, M, Qian, M D, Ribadeneira, D, Christ, R R, Wexler, C P, Decicco

Publikováno v: Journal of medicinal chemistry. 44(21)

A pharmacophore model of the P1' site, specific for aggrecanase, was defined using the specificity studies of the matrix metalloproteinases and the similar biological activity of aggrecanase and MMP-8. Incorporation of the side chain of a tyrosine re

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::66b60bcb0ff1f67244f659e6c7b37881
https://pubmed.ncbi.nlm.nih.gov/11585439

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Effects of structural modifications on the intestinal permeability of angiotensin II receptor antagonists and the correlation of in vitro, in situ, and in vivo absorption

Autor: M D, Ribadeneira, B J, Aungst, C J, Eyermann, S M, Huang

Publikováno v: Pharmaceutical research. 13(2)

The effects of structural modifications on the membrane permeability of angiotensin II (Ang II) receptor antagonists and the usefulness of in vitro and in situ intestinal absorption models in predicting in vivo absorption or bioavailability were inve

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::563b0d1942d3b0f9f3579025906808f2
https://pubmed.ncbi.nlm.nih.gov/8932441

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