Výsledky vyhledávání - "M D, Perloff"

Differential metabolism of midazolam in mouse liver and intestine microsomes: a comparison of cytochrome P450 activity and expression

Autor: M D, Perloff, L L, Von Moltke, D J, Greenblatt

Publikováno v: Xenobiotica; the fate of foreign compounds in biological systems. 33(4)

1. Although multiple cytochrome P450s (CYP) contribute to hepatic phase I metabolism, CYP3A is the principal subfamily present in human and mouse small intestine. 2. Differences in phase I metabolism were investigated using midazolam (MDZ) hydroxylat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::850d4f490db9f79d5dbdb5405cb86149
https://pubmed.ncbi.nlm.nih.gov/12745872

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Saint John's wort: an in vitro analysis of P-glycoprotein induction due to extended exposure

Autor: M D, Perloff, L L, von Moltke, E, Störmer, R I, Shader, D J, Greenblatt

Publikováno v: British journal of pharmacology. 134(8)

1. Chronic use of Saint John's wort (SJW) has been shown to lower the bioavailability for a variety of co-administered drugs including indinavir, cyclosporin, and digoxin. Decreases in intestinal absorption through induction of the multidrug resistan

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::85e07b530d462a407a8ab0c9e8929c94
https://pubmed.ncbi.nlm.nih.gov/11739235

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Methadone inhibits rhodamine123 transport in Caco-2 cells

Autor: E, Störmer, M D, Perloff, L L, von Moltke, D J, Greenblatt

Publikováno v: Drug metabolism and disposition: the biological fate of chemicals. 29(7)

This study investigated the effects of racemic methadone (MET) on P-glycoprotein (P-gp) activity in cell culture. MET showed no differential rates of passage between the basolateral to apical (B to A) and apical to basolateral (A to B) direction acro

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::2db992809b345468f99a3ae78dcf7320
https://pubmed.ncbi.nlm.nih.gov/11408360

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Midazolam and triazolam biotransformation in mouse and human liver microsomes: relative contribution of CYP3A and CYP2C isoforms

Autor: M D, Perloff, L L, von Moltke, M H, Court, T, Kotegawa, R I, Shader, D J, Greenblatt

Publikováno v: The Journal of pharmacology and experimental therapeutics. 292(2)

Midazolam (MDZ) and triazolam (TRZ) hydroxylation, reactions considered to be cytochrome P-4503A (CYP3A)-mediated in humans, were examined in mouse and human liver microsomes. In both species, alpha- and 4-hydroxy metabolites were the principal produ

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::04cd9176ee8bc55c130db41ed2d3634e
https://pubmed.ncbi.nlm.nih.gov/10640299

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