Výsledky vyhledávání - "M D, Minnich"

Characterization of Mamalian GS-α Proteins Expressed in Yeast

Autor: David J. Ecker, M. Gross, M. D. Minnich, Stanley T. Crooke, Julian B. Marsh, David Powers, Tauseef R. Butt, K. Hoyle, Jeffrey M. Stadel

Publikováno v: Journal of Receptor Research. 14:357-379

The guanine nucleotide regulatory protein, GS, mediates transmembrane signaling by coupling membrane receptors to the stimulation of adenylyl cyclase activity. The full length coding sequences for the M(r) = 42-45,000, short form (S), and M(r) = 46-5

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::06f1a87c3851c5b874ebba67f8209305
https://doi.org/10.3109/10799899409101510

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Inhibition of human immunodeficiency virus-1 protease by a C2-symmetric phosphinate. Synthesis and crystallographic analysis

Autor: S S, Abdel-Meguid, B, Zhao, K H, Murthy, E, Winborne, J K, Choi, R L, DesJarlais, M D, Minnich, J S, Culp, C, Debouck, T A, Tomaszek

Publikováno v: Biochemistry. 32(31)

The human immunodeficiency virus type 1 (HIV-1) protease is a potential target of acquired immune deficiency syndrome (AIDS) therapy. A highly potent, perfectly symmetrical phosphinate inhibitor of this enzyme, SB204144, has been synthesized. It is a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::977ff3a265eaf6a31672893596b3b42f
https://pubmed.ncbi.nlm.nih.gov/8347601

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The crystal structures at 2.2-A resolution of hydroxyethylene-based inhibitors bound to human immunodeficiency virus type 1 protease show that the inhibitors are present in two distinct orientations

Autor: K H, Murthy, E L, Winborne, M D, Minnich, J S, Culp, C, Debouck

Publikováno v: The Journal of biological chemistry. 267(32)

As part of a structure-based drug design program directed against enzyme targets in the human immunodeficiency virus (HIV), we have determined the three-dimensional structures of the HIV type 1 protease complexed with two hydroxyethylene-based inhibi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::ac444d836f2cc3499558c58f0a69a38f
https://pubmed.ncbi.nlm.nih.gov/1429626

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Immuno cross-reactivity suggests that catecholamine biosynthesis enzymes and beta-adrenergic receptors may be related

Autor: R G, Shorr, M D, Minnich, A, Varrichio, M W, Strohsacker, L, Gotlib, L I, Kruse, W E, DeWolf, S T, Crooke

Publikováno v: Molecular pharmacology. 32(1)

Turkey red blood cell, beta 1-adrenergic receptors (BARs) were prepared to electrophoretic homogeneity by affinity chromatography, size exclusion high performance liquid chromatography, and preparative sodium dodecyl sulfate-polyacrylamide gel electr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::d205ea0e26bd82a5d8486513688a9d5f
https://pubmed.ncbi.nlm.nih.gov/3039336

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