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Topoisomerase II activity involved in cleaving DNA into topological domains is altered in a multiple drug-resistant Chinese hamster ovary cell line

Autor: D M, Sullivan, L A, Eskildsen, K R, Groom, C D, Webb, M D, Latham, A W, Martin, S R, Wellhausen, P E, Kroeger, T C, Rowe

Publikováno v: Molecular pharmacology. 43(2)

Drug resistance to inhibitors of DNA topoisomerase II can result from qualitative or quantitative alterations in the target enzyme, topoisomerase II, or from perturbations in drug transport that may or may not involve P-glycoprotein. In the present s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::bb4627c72411dae130a71e073d74d974
https://pubmed.ncbi.nlm.nih.gov/8094226

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Attenuated topoisomerase II content directly correlates with a low level of drug resistance in a Chinese hamster ovary cell line

Autor: C D, Webb, M D, Latham, R B, Lock, D M, Sullivan

Publikováno v: Cancer research. 51(24)

A new multiple drug-resistant Chinese hamster ovary cell line, CHO-SMR5, has been isolated which demonstrates a direct correlation between reduced cellular topoisomerase II activity (5-fold reduction) and a low level of resistance (3- to 7-fold) to t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::9ee29c5415b55cc7ecf6b527ec6a6c7c
https://pubmed.ncbi.nlm.nih.gov/1660341

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WEIGHT GAIN OF KENYAN SCHOOL CHILDREN INFECTED WITH HOOKWORM, TRICHURIS TRICHIURA AND ASCARIS LUMBRICOIDES IS IMPROVED FOLLOWING ONCE- AND TWICE-YEARLY TREATMENT WITH ALBENDAZOLE

Autor: L. S. Stephenson, M. D. Latham, E. J. Adams

Publikováno v: Pediatrics. 95:895-895

Hookworm, Ascaris lumbricoides, and Trichuris trichiura each are estimated to infect ⅙ to ¼ of the world's population. Many studies show the association between infestation with these parasites and poor growth in children. Although the long-term s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::422f21f92c5030f6f83c4c8c896f8efd
https://doi.org/10.1542/peds.95.6.895

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Proliferation-dependent topoisomerase II content as a determinant of antineoplastic drug action in human, mouse, and Chinese hamster ovary cells

Autor: D M, Sullivan, M D, Latham, W E, Ross

Publikováno v: Cancer research. 47(15)

We have shown previously that quiescent Chinese hamster ovary (CHO) cells are less sensitive than log phase CHO cells to the cytotoxic and DNA cleavage effects of etoposide, a drug which appears to act via DNA topoisomerase II. This loss of sensitivi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::2c4c4ea961bd0148608fd9f736eb9237
https://pubmed.ncbi.nlm.nih.gov/3038304

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