Characterisation of the immune microenvironment of primary breast cancer and brain metastasis reveals depleted T-cell response associated to ARG2 expression

Autor: A, Giannoudis, D, Varešlija, V, Sharma, R, Zakaria, A, Platt-Higgins, P S, Rudland, M D, Jenkinson, L S, Young, C, Palmieri

Publikováno v: ESMO Open. 7:100636

Immune checkpoint inhibition is an established treatment in programmed death-ligand 1 (PD-L1)-positive metastatic triple-negative (TN) breast cancer (BC). However, the immune landscape of breast cancer brain metastasis (BCBM) remains poorly defined.T

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f95e469e4966adf9d81df380b19bb455
https://doi.org/10.1016/j.esmoop.2022.100636

Abstracts from the 2011 BNOS Conference, June 29 - July 1, 2011, Homerton College, Cambridge

Autor: S. Ammoun, L. Zhou, M. Barczyk, D. Hilton, S. Hafizi, C. Hanemann, K. S. Lehnus, L. K. Donovan, G. J. Pilkington, Q. An, I. A. Anderson, S. Thomson, M. Bailey, E. Lekka, J. Law, C. Davis, K. Banfill, C. Loughrey, P. Hatfield, D. Bax, R. Elliott, R. Bishop, K. Taylor, L. Marshall, N. Gaspar, M. Viana-Pereira, R. Reis, J. Renshaw, A. Ashworth, C. Lord, C. Jones, C. Bellamy, L. Shaw, J. Alder, A. Shorrocks, R. Lea, S. Birks, M. Burnet, G. Pilkington, J. D. Bruch, J. Ho, C. Watts, S. J. Price, S. Camp, V. Apostolopoulos, A. Mehta, F. Roncaroli, D. Nandi, B. Clark, M. Mackinnon, N. MacLeod, W. Stewart, A. Chalmers, A. Cole, G. Hanna, K. Bailie, D. Conkey, J. Harney, C. Darlow, S. Chapman, L. Mohsen, S. Price, L. Donovan, H. Dyer, H. Lord, K. Fletcher, R. das Nair, J. MacNiven, S. Basu, P. Byrne, L. Glancz, G. Critchley, M. Grech-Sollars, D. Saunders, K. Phipps, J. Clayden, C. Clark, A. Greco, S. Acquati, S. Marino, S. Hammouche, S. P. Wilkins, T. Smith, A. Brodbelt, S. Clark, A. H. L. Wong, P. Eldridge, J. O. Farah, J. Bruch, G. Lamb, S. Smith, A. James, M. Glegg, T. Jeffcote, S. Boulos, P. Robbins, N. Knuckey, A. Banigo, A. R. Brodbelt, M. D. Jenkinson, J. N. Jeyapalan, M. A. Mumin, T. Forshew, A. R. Lawson, R. G. Tatevossian, T. S. Jacques, D. Sheer, J. Kilday, K. Wright, S. Leavy, J. Lowe, E. Schwalbe, S. Clifford, R. Gilbertson, B. Coyle, R. Grundy, P. Kinsella, M. Clynes, V. Amberger-Murphy, N. Barron, S. R. Lambert, D. Jones, D. Pearson, I. Ichimura, V. Collins, L. Steele, P. Sinha, P. Chumas, J. Tyler, D. Ogawa, E. Chiocca, M. DeLay, A. Bronisz, M. Nowicki, J. Godlewski, S. Lawler, M. K. Lee, M. Javadpour, P. Abel, T. Dawson, B. Lea, C. S.-K. Lim, P. L. Grundy, M. Pendleton, A. Williamson, A. Merve, X. Zhang, S. Miller, H. A. Rogers, P. Lyon, V. Rand, M. Adamowicz-Brice, S. C. Clifford, J. T. Hayden, S. Dyer, S. Pfister, A. Korshunov, M.-A. Brundler, R. G. Grundy, M. Nankivell, P. Mulvenna, R. Barton, P. Wilson, C. Faivre-Finn, C. Pugh, R. Langley, D. Ngoga, D. Tennant, A. Williams, P. Moss, G. Cruickshank, K. Owusu-Agyemang, S. Bell, J. St.George, S. G. Piccirillo, S. Qadri, E. Pirola, M. Jenkinson, R. Rahman, C. Rahman, D. MacArthur, F. Rose, K. Shakesheff, C. Carroll, P. Watson, M. Hawkins, H. Spoudeas, D. Walker, T. Holland, H. Ring, A. Rooney, S. McNamara, M. Fraser, R. Rampling, A. Carson, R. Grant, J. Royds, S. Al Nadaf, A. Ahn, Y.-J. Chen, A. Wiles, D. Jellinek, A. Braithwaite, B. Baguley, M. MacFarlane, N. Hung, T. Slatter, S. Rusbridge, N. Walmsley, S. Griffiths, P. Wilford, J. Rees, D. Ryan, P. Liu, S. Galavotti, M. Shaked-Rabi, E. Tulchinsky, S. Brandner, P. Salomoni, A. Schulte, H. S. Gunther, S. Zapf, S. Riethdorf, M. Westphal, K. Lamszus, S. K. Selvanathan, H. J. Salminen, S. Setua, M. E. Welland, M. Shevtsov, W. Khachatryan, A. Kim, K. Samochernych, A. Pozdnyakov, I. V. Guzhova, I. V. Romanova, B. Margulis, J. Barrow, D. Macarthur, A. Long, Z. Maherally, J. R. Smith, L. Dickson, S. Prabhu, F. Harris, T. J. Snape, M. Sussman, S. Wilne, W. Whitehouse, G. Chow, J.-F. Liu, T. Snape, A. Karakoula, F. Rowther, T. Warr, A. Zisakis, V. Varsos, A. Panteli, O. Karypidou, A. Zampethanis, A. Fotovati, S. Abu-Ali, P.-S. Wang, L. Deleyrolle, C. Lee, J. Triscott, J. Y. Chen, S. Franciosi, Y. Nakamura, Y. Sugita, T. Uchiumi, M. Kuwano, B. R. Leavitt, S. K. Singh, A. Jury, H. Wakimoto, B. A. Reynolds, C. J. Pallen, S. E. Dunn, S. Shepherd, S. Scott, D. Bowyer, L. Wallace, B. Hacking, R. Jena, J. Gillard, M. Verraeult, B. Reynolds, C. Dunham, M. Bally, J. Hukin, S. Singhal, S. Singh, S. Dunn

Publikováno v: Neuro-Oncology. 13:ii1-ii14

INTRODUCTION: Substituted indoles and related structures have been shown to exhibit potent anticancer activity against breast cancer cell lines. Here, the effects of structurally similar substituted indoles against the human glial cancer cell lines,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1fd03645d5059bcd6cdb359145b1432b
https://doi.org/10.1093/neuonc/nor144

Diffusion weighted MRI is a promising imaging biomarker in brain metastases

Autor: R, Zakaria, M D, Jenkinson

Publikováno v: Journal of neuro-oncology. 121(2)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::d47363ce39c8688bf6054657fecc2f70
https://pubmed.ncbi.nlm.nih.gov/24760414

Interaction between bacterial peptides, neutrophils and goblet cells: a possible mechanism for neutrophil recruitment and goblet cell depletion in colitis

Autor: K, Leiper, B J, Campbell, M D, Jenkinson, J, Milton, L G, Yu, J, Democratis, J M, Rhodes

Publikováno v: Clinical science (London, England : 1979). 101(4)

Goblet cell depletion occurs in various forms of colitis, but its mechanism is unknown. We have investigated two linked hypotheses: (i) that bacterial peptides, such as formyl-methionyl-leucyl-phenylalanine (fMLP), interact with epithelial cells indu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::565810e38982bb4095597c5abf0e7708
https://pubmed.ncbi.nlm.nih.gov/11566077