Zobrazeno 1 - 10
of 461
pro vyhledávání: '"M Crews"'
Autor:
Shanique Alabi, Saul Jaime-Figueroa, Zhan Yao, Yijun Gao, John Hines, Kusal T. G. Samarasinghe, Lea Vogt, Neal Rosen, Craig M. Crews
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-11 (2021)
Hundreds of BRAF mutations have been identified in patients with cancer but currently approved drugs only target BRAF V600 mutants. Here, the authors develop a vemurafenib-based PROTAC that induces degradation of all classes of BRAF mutants without a
Externí odkaz:
https://doaj.org/article/c199e2f0eb92437a873d93ab5b38d197
Publikováno v:
ACS Central Science, Vol 6, Iss 8, Pp 1367-1375 (2020)
Externí odkaz:
https://doaj.org/article/fd36cde10c1e43fbb63ded6891baa8a3
Publikováno v:
AIP Advances, Vol 11, Iss 10, Pp 105111-105111-7 (2021)
In this work, we present the cubic crystal elastic constants of a fully crystallized white dwarf stellar core. Elastic constants were calculated utilizing modal analysis of three-dimensional single-layer and stratified multi-layer crystalline core mo
Externí odkaz:
https://doaj.org/article/bbca3c423c5d4e00aee6caa8777b05f2
Publikováno v:
ACS Central Science, Vol 5, Iss 10, Pp 1682-1690 (2019)
Externí odkaz:
https://doaj.org/article/275e9de7d62243c0bbe092c107de5671
Autor:
Dhanusha A. Nalawansha, Stacey-Lynn Paiva, Diane N. Rafizadeh, Mariell Pettersson, Liena Qin, Craig M. Crews
Publikováno v:
ACS Central Science, Vol 5, Iss 6, Pp 1079-1084 (2019)
Externí odkaz:
https://doaj.org/article/4459b5e89f304e7abf4569b12a2b85f1
Autor:
Blake E. Smith, Stephen L. Wang, Saul Jaime-Figueroa, Alicia Harbin, Jing Wang, Brian D. Hamman, Craig M. Crews
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-13 (2019)
PROTACs enable targeted protein degradation by recruiting an E3 ligase to a specific substrate but the determinants of selectivity are not fully understood. Here, the authors show that varying the linker between warhead and E3 ligand and the orientat
Externí odkaz:
https://doaj.org/article/86ec9e4d91cb498bb96bd2e90667c3f4
Publikováno v:
Nature Reviews Clinical Oncology. 20:265-278
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e98558b6900c1dadd919b04129a30e9b
https://doi.org/10.1038/s41571-023-00736-3
https://doi.org/10.1038/s41571-023-00736-3
Publikováno v:
Journal of the American Chemical Society. 145:4045-4055
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e18bcc97439c09e8d8e6fd10b91d1b7c
https://doi.org/10.1021/jacs.2c11706
https://doi.org/10.1021/jacs.2c11706
Publikováno v:
eLife, Vol 9 (2020)
Axolotls and other salamanders can regenerate entire limbs after amputation as adults, and much recent effort has sought to identify the molecular programs controlling this process. While targeted mutagenesis approaches like CRISPR/Cas9 now permit ge
Externí odkaz:
https://doaj.org/article/6cb4be7d445d43168d6e9b16052a967f
Autor:
Philipp M. Cromm, Craig M. Crews
Publikováno v:
ACS Central Science, Vol 3, Iss 8, Pp 830-838 (2017)
Externí odkaz:
https://doaj.org/article/8dfea66018e343d4a5d8d3049c867669