Zobrazeno 1 - 10
of 463
pro vyhledávání: '"M Crean"'
Publikováno v:
QRB Discovery, Vol 5 (2024)
Protein tyrosine phosphatases (PTPs) are crucial regulators of cellular signaling. Their activity is regulated by the motion of a conserved loop, the WPD-loop, from a catalytically inactive open to a catalytically active closed conformation. WPD-loop
Externí odkaz:
https://doaj.org/article/32a8f2bafca546caae7c24425fd85836
Autor:
Andrew M. Crean, MRCP, FRCR, Lara Gharibeh, PhD, Zain Saleem, David Glineur, MD, Gyaandeo Maharaj, MD, FRCSC, Juan B. Grau, MD
Publikováno v:
CJC Open, Vol 4, Iss 11, Pp 921-928 (2022)
Hypertrophic cardiomyopathy (HCM) is one of the commonest inherited cardiac abnormalities. The disorder is clinically and genetically heterogeneous and is characterized by left ventricular wall thickening that is not explained by abnormal loading con
Externí odkaz:
https://doaj.org/article/d7fc6407d10144ee8d79c55eba834871
Autor:
Anahita Tavoosi, Juliana Brenande de Oliveira Brito, Huda El Mais, Toby D. Small, Andrew M. Crean, Benjamin J.W. Chow, Gary R. Small
Publikováno v:
International Journal of Cardiology: Heart & Vasculature, Vol 44, Iss , Pp 101166- (2023)
Rationale and objectives: Determine in cardiac amyloid (CA) patients, whether cardiac CT derived extracellular volume (ECV) correlates with that obtained by MRI. Perform this correlation with single (SECT) versus dual energy (DECT) CT and evaluate wh
Externí odkaz:
https://doaj.org/article/e7a8064c41c8494fb5aaabbedab59a87
Autor:
Nigel S. Tan, Djeven P. Deva, Kim A. Connelly, Paul Angaran, Iqwal Mangat, Laura Jimenez-Juan, Ming-Yen Ng, Kamran Ahmad, Vamshi K. Kotha, Joao A. C. Lima, Andrew M. Crean, Paul Dorian, Andrew T. Yan
Publikováno v:
Journal of Cardiovascular Magnetic Resonance, Vol 23, Iss 1, Pp 1-9 (2021)
Abstract Background Cardiovascular magnetic resonance (CMR) is increasingly used in the evaluation of patients who are potential candidates for implantable cardioverter-defibrillator (ICD) therapy to assess left ventricular (LV) ejection fraction (LV
Externí odkaz:
https://doaj.org/article/3fac42991193430ea4ac1500f23a2955
Publikováno v:
JACS Au, Vol 1, Iss 5, Pp 646-659 (2021)
Externí odkaz:
https://doaj.org/article/da102b1a014a4b79994618d7468aebba
Autor:
James S. Smith, Katrina M. Lappin, Stephanie G. Craig, Fabio G. Liberante, Clare M. Crean, Simon S. McDade, Alexander Thompson, Ken I. Mills, Kienan I. Savage
Publikováno v:
Journal of Translational Medicine, Vol 18, Iss 1, Pp 1-18 (2020)
Abstract Background The cohesin complex plays a major role in folding the human genome into 3D structural domains. Mutations in members of the cohesin complex are known early drivers of myelodysplastic syndromes (MDS) and acute myeloid leukaemia (AML
Externí odkaz:
https://doaj.org/article/3da9f9f6b1b142149744239d66e7c7a9
Autor:
Rory M. Crean, Bruce J. MacLachlan, Florian Madura, Thomas Whalley, Pierre J. Rizkallah, Christopher J. Holland, Catriona McMurran, Stephen Harper, Andrew Godkin, Andrew K. Sewell, Christopher R. Pudney, Marc W. van der Kamp, David K. Cole
Publikováno v:
Molecular Therapy: Oncolytics, Vol 18, Iss , Pp 443-456 (2020)
Immuno-oncology approaches that utilize T cell receptors (TCRs) are becoming highly attractive because of their potential to target virtually all cellular proteins, including cancer-specific epitopes, via the recognition of peptide-human leukocyte an
Externí odkaz:
https://doaj.org/article/468343d29a914222a4306cde545a8b9d
Publikováno v:
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 10, Iss 22 (2021)
The anomalous aortic origin of the right coronary artery (AAORCA) from the left sinus is a congenital anomaly affecting both the origin and course of the right coronary artery. AAORCA is nowadays easily and increasingly recognized by several cardiac
Externí odkaz:
https://doaj.org/article/420273864a0f4e21948861fb104d5f3e
Autor:
Emilie Laflamme, Rafael Alonso-Gonzalez, S. Lucy Roche, Rachel M. Wald, Lorna Swan, Candice K. Silversides, Sara A. Thorne, Eric M. Horlick, Lee N. Benson, Mark Osten, Edward Hickey, David J. Barron, Jack M. Colman, Erwin Oechslin, Andrew M. Crean
Publikováno v:
International Journal of Cardiology Congenital Heart Disease, Vol 4, Iss , Pp 100169- (2021)
Background: Anomalous origin of a coronary artery from the pulmonary artery (PA) is a rare condition that usually presents in childhood. The aim of this study is to describe its characteristics in unrepaired adults. Methods: We conducted a retrospect
Externí odkaz:
https://doaj.org/article/df88318c17be4c899bc9e2c5d8d8ffe7
Autor:
Raghu V. G. Peddapatla, Conor Slevin, Gerard Sheridan, Caoimhe Beirne, Shrikant Swaminathan, Ivan Browning, Clare O’Reilly, Zelalem A. Worku, David Egan, Stephen Sheehan, Abina M. Crean
Publikováno v:
Pharmaceutics, Vol 14, Iss 4, p 695 (2022)
The ability to predict formulation behaviour at production scale during formulation design can reduce the time to market and decrease product development costs. However, it is challenging to extrapolate compaction settings for direct compression form
Externí odkaz:
https://doaj.org/article/1da0eacebdde4c43bbe0a73c22776da2