Zobrazeno 1 - 10
of 268
pro vyhledávání: '"M Cowell"'
Autor:
Nolwazi Z. Gcwensa, Dreson L. Russell, Khaliah Y. Long, Charlotte F. Brzozowski, Xinran Liu, Karen L. Gamble, Rita M. Cowell, Laura A. Volpicelli-Daley
Publikováno v:
Neurobiology of Disease, Vol 199, Iss , Pp 106595- (2024)
Parkinson's disease (PD) and Dementia with Lewy bodies (DLB) are characterized by neuronal α-synuclein (α-syn) inclusions termed Lewy Pathology, which are abundant in the amygdala. The basolateral amygdala (BLA), in particular, receives projections
Externí odkaz:
https://doaj.org/article/090e4f4033cc4d278eafd11471bee7dd
Autor:
John W. McLean, Mary VanHart, Madilyn P. McWilliams, Charlene B. Farmer, David K. Crossman, Rita M. Cowell, Julie A. Wilson, Scott M. Wilson
Publikováno v:
Current Research in Neurobiology, Vol 7, Iss , Pp 100138- (2024)
The endosomal sorting complexes required for transport (ESCRT) pathway is composed of a series of protein complexes that are essential for sorting cargo through the endosome. In neurons, the ESCRT pathway is a key mediator of many cellular pathways t
Externí odkaz:
https://doaj.org/article/dc9fe283857042a9a222a3f2404e0ed9
Autor:
Skylar E. Davis, Anna K. Cook, Justin A. Hall, Yuliya Voskobiynyk, Nancy V. Carullo, Nicholas R. Boyle, Ahmad R. Hakim, Kristian M. Anderson, Kierra P. Hobdy, Derian A. Pugh, Charles F. Murchison, Laura J. McMeekin, Micah Simmons, Katherine A. Margolies, Rita M. Cowell, Alissa L. Nana, Salvatore Spina, Lea T. Grinberg, Bruce L. Miller, William W. Seeley, Andrew E. Arrant
Publikováno v:
Acta Neuropathologica Communications, Vol 11, Iss 1, Pp 1-19 (2023)
Abstract Loss of function progranulin (GRN) mutations are a major autosomal dominant cause of frontotemporal dementia (FTD). Patients with FTD due to GRN mutations (FTD-GRN) develop frontotemporal lobar degeneration with TDP-43 pathology type A (FTLD
Externí odkaz:
https://doaj.org/article/cb7d9e8149f4472c81b6d7612826356c
Autor:
S. N. Fox, L. J. McMeekin, C. H. Savage, K. L. Joyce, S. M. Boas, M. S. Simmons, C. B. Farmer, J. Ryan, L. Pereboeva, K. Becker, J. Auwerx, S. Sudarshan, J. Ma, A. Lee, R. C. Roberts, D. K. Crossman, A. Kralli, R. M. Cowell
Publikováno v:
npj Parkinson's Disease, Vol 8, Iss 1, Pp 1-19 (2022)
Abstract Many studies implicate mitochondrial dysfunction as a key contributor to cell loss in Parkinson disease (PD). Previous analyses of dopaminergic (DAergic) neurons from patients with Lewy-body pathology revealed a deficiency in nuclear-encoded
Externí odkaz:
https://doaj.org/article/ea2bd0f17cd2417ea87f86dbe8b0be2d
Publikováno v:
Frontiers in Human Neuroscience, Vol 16 (2022)
Moral reasoning develops rapidly in early childhood. Recent evidence from cognitive neuroscience literature suggests that the development of moral reasoning is supported by an integration of cognitive and affective components. However, the role of cu
Externí odkaz:
https://doaj.org/article/d6f7f312afad4b59a6408b33b873a69e
Autor:
Allison R. Fusilier, Jennifer A. Davis, Jodi R. Paul, Stefani D. Yates, Laura J. McMeekin, Lacy K. Goode, Mugdha V. Mokashi, Natalie Remiszewski, Thomas van Groen, Rita M. Cowell, Lori L. McMahon, Erik D. Roberson, Karen L. Gamble
Publikováno v:
Neurobiology of Disease, Vol 158, Iss , Pp 105454- (2021)
Patients with Alzheimer's disease (AD) often have fragmentation of sleep/wake cycles and disrupted 24-h (circadian) activity. Despite this, little work has investigated the potential underlying day/night disruptions in cognition and neuronal physiolo
Externí odkaz:
https://doaj.org/article/170f4063c70843f29032fe341d423aa1
Autor:
Gelare Ghajar-Rahimi, Amie M. Traylor, Bini Mathew, James R. Bostwick, N Miranda Nebane, Anna A. Zmijewska, Stephanie K. Esman, Saakshi Thukral, Ling Zhai, Vijaya Sambandam, Rita M. Cowell, Mark J. Suto, James F. George, Corinne E. Augelli-Szafran, Anupam Agarwal
Publikováno v:
Antioxidants, Vol 11, Iss 10, p 1888 (2022)
Acute kidney injury (AKI) is a major public health concern with significant morbidity and mortality and no current treatments beyond supportive care and dialysis. Preclinical studies have suggested that heme-oxygenase-1 (HO-1), an enzyme that catalyz
Externí odkaz:
https://doaj.org/article/25f0f94d8f124a2fac06bb9aa63b0b1c
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 15 (2021)
Parkinson’s disease (PD) is a progressive neurodegenerative disease that impairs movement as well as causing multiple other symptoms such as autonomic dysfunction, rapid eye movement (REM) sleep behavior disorder, hyposmia, and cognitive changes. L
Externí odkaz:
https://doaj.org/article/d1a17e596a4543c3aded2a04905f74fa
Autor:
Mahendra Singh, Kiran Sapkota, Kenji Sakimura, Masanobu Kano, Rita M Cowell, Linda Overstreet-Wadiche, John J Hablitz, Kazu Nakazawa
Publikováno v:
Neuroscience. 513:38-53
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ff131dc378a4109e86e27840f1f63292
https://doi.org/10.1016/j.neuroscience.2023.01.007
https://doi.org/10.1016/j.neuroscience.2023.01.007
Publikováno v:
Antioxidants, Vol 11, Iss 1, p 8 (2021)
Oxidative stress has been implicated in the etiology and pathobiology of various neurodegenerative diseases. At baseline, the cells of the nervous system have the capability to regulate the genes for antioxidant defenses by engaging nuclear factor er
Externí odkaz:
https://doaj.org/article/e2378f5c431b47ea8e8509a3741c9b2c