Zobrazeno 1 - 10
of 317
pro vyhledávání: '"M Coccia"'
Autor:
Alessandra Zevini, Enrico Palermo, Daniele Di Carlo, Magdalini Alexandridi, Serena Rinaldo, Alessio Paone, Francesca Cutruzzola, Marilena P. Etna, Eliana M. Coccia, David Olagnier, John Hiscott
Publikováno v:
Frontiers in Cellular and Infection Microbiology, Vol 12 (2022)
Dendritic cells (DCs) are important mediators of the induction and regulation of adaptive immune responses following microbial infection and inflammation. Sensing environmental danger signals including viruses, microbial products, or inflammatory sti
Externí odkaz:
https://doaj.org/article/d66c57fed7be4788a8aa5072998ed0b6
Autor:
Martina Severa, Roberta A Diotti, Marilena P Etna, Fabiana Rizzo, Stefano Fiore, Daniela Ricci, Marco Iannetta, Alessandro Sinigaglia, Alessandra Lodi, Nicasio Mancini, Elena Criscuolo, Massimo Clementi, Massimo Andreoni, Stefano Balducci, Luisa Barzon, Paola Stefanelli, Nicola Clementi, Eliana M Coccia
Publikováno v:
PLoS Pathogens, Vol 17, Iss 9, p e1009878 (2021)
SARS-CoV-2 fine-tunes the interferon (IFN)-induced antiviral responses, which play a key role in preventing coronavirus disease 2019 (COVID-19) progression. Indeed, critically ill patients show an impaired type I IFN response accompanied by elevated
Externí odkaz:
https://doaj.org/article/ad30e9e2c6c54cdfbb29689d53a04fe4
Autor:
Marilena P. Etna, Martina Severa, Valerio Licursi, Manuela Pardini, Melania Cruciani, Fabiana Rizzo, Elena Giacomini, Gianfranco Macchia, Orazio Palumbo, Raffaella Stallone, Massimo Carella, Mark Livingstone, Rodolfo Negri, Sandra Pellegrini, Eliana M. Coccia
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
In human primary dendritic cells (DC) rapamycin—an autophagy inducer and protein synthesis inhibitor—overcomes the autophagy block induced by Mycobacterium tuberculosis (Mtb) and promotes a Th1 response via IL-12 secretion. Here, the immunostimul
Externí odkaz:
https://doaj.org/article/eb748d7cd1c049debd23f736020b2119
Autor:
Marilena P Etna, Aurora Signorazzi, Daniela Ricci, Martina Severa, Fabiana Rizzo, Elena Giacomini, Andrea Gaggioli, Isabelle Bekeredjian-Ding, Anke Huckriede, Eliana M Coccia
Publikováno v:
PLoS Pathogens, Vol 17, Iss 4, p e1009505 (2021)
The Tick-borne encephalitis virus (TBEV) causes different disease symptoms varying from asymptomatic infection to severe encephalitis and meningitis suggesting a crucial role of the human host immune system in determining the fate of the infection. T
Externí odkaz:
https://doaj.org/article/750e33173eeb4ede945877d605a1d8de
Autor:
Ilenia Pacella, Francesca Romana Spinelli, Martina Severa, Eleonora Timperi, Gloria Tucci, Marta Zagaglioni, Fulvia Ceccarelli, Fabiana Rizzo, Eliana M Coccia, Roosheel S Patel, Marta Martin‐Fernandez, Dusan Bogunovic, Fabrizio Conti, Vincenzo Barnaba, Silvia Piconese
Publikováno v:
Clinical & Translational Immunology, Vol 9, Iss 12, Pp n/a-n/a (2020)
Abstract Objectives Type I interferons (IFNs) inhibit regulatory T‐cell (Treg) expansion and activation, making them beneficial in antiviral responses, but detrimental in autoimmune diseases. Herein, we investigate the role of ISG15 in human Tregs
Externí odkaz:
https://doaj.org/article/a26ba7d47ff2480a8aa93f8d37367193
Autor:
Aurora Signorazzi, Jeroen L. A. Pennings, Marilena P. Etna, Malou Noya, Eliana M. Coccia, Anke Huckriede
Publikováno v:
Vaccines, Vol 9, Iss 6, p 664 (2021)
Tick-borne encephalitis virus (TBEV) infection can lead to inflammation of the central nervous system. The disease can be effectively prevented by whole inactivated virus vaccines. Here, we investigated the innate immune profile induced in vitro by t
Externí odkaz:
https://doaj.org/article/d4df25421400459187d17fa7866e5bee
Autor:
Sundararajan Srinivasan, Martina Severa, Fabiana Rizzo, Ramesh Menon, Elena Brini, Rosella Mechelli, Vittorio Martinelli, Paul Hertzog, Marco Salvetti, Roberto Furlan, Gianvito Martino, Giancarlo Comi, Eliana M. Coccia, Cinthia Farina
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-9 (2017)
Abstract Recent evidence indicates that single multiple sclerosis (MS) susceptibility genes involved in interferon (IFN) signaling display altered transcript levels in peripheral blood of untreated MS subjects, suggesting that responsiveness to endog
Externí odkaz:
https://doaj.org/article/5eca37b29ea3460fbd37602ded3bbfa2
Autor:
Melania Cruciani, Silvia Sandini, Marilena P. Etna, Elena Giacomini, Romina Camilli, Martina Severa, Fabiana Rizzo, Fabio Bagnoli, John Hiscott, Eliana M. Coccia
Publikováno v:
Frontiers in Immunology, Vol 10 (2019)
Understanding Staphylococcus aureus (S. aureus)–host immune system interaction is crucial to meet the tremendous medical need associated with this life-threatening bacterial infection. Given the crucial role of dendritic cells (DC) in dictating imm
Externí odkaz:
https://doaj.org/article/2af1652bc6c74455961e079ff76ba09b
Autor:
Francesca Ligorio, Serena Di Cosimo, Paolo Verderio, Chiara Maura Ciniselli, Sara Pizzamiglio, Lorenzo Castagnoli, Tiziana Triulzi, Elda Tagliabue, Sarra El-Abed, Miguel Izquierdo, Evandro de Azambuja, Paolo Nuciforo, Jens Huober, Luca Moscetti, Wolfgang Janni, M Coccia-Portugal, Paola Corsetto, Antonino Belfiore, Daniele Lorenzini, Maria Grazia Daidone, Andrea VIngiani, Serenella M Pupa, Giancarlo Pruneri, Claudio Vernieri
Publikováno v:
Cancer Research. 82:P2-13
Background: Despite great efforts to identify tumor-related prognostic biomarkers in early-stage Human Epidermal growth factor Receptor 2 (HER2)-positive Breast Cancer (HER2+ BC), reliable determinants of long-term clinical outcomes are lacking. HER2
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d0680dee4cc41e51a47d3417d8fca249
https://doi.org/10.1158/1538-7445.sabcs21-p2-13-12
https://doi.org/10.1158/1538-7445.sabcs21-p2-13-12
Autor:
Marilena P Etna, Alessandro Sinigaglia, Angela Grassi, Elena Giacomini, Alessandra Romagnoli, Manuela Pardini, Martina Severa, Melania Cruciani, Fabiana Rizzo, Eleni Anastasiadou, Barbara Di Camillo, Luisa Barzon, Gian Maria Fimia, Riccardo Manganelli, Eliana M Coccia
Publikováno v:
PLoS Pathogens, Vol 14, Iss 1, p e1006790 (2018)
Autophagy is a primordial eukaryotic pathway, which provides the immune system with multiple mechanisms for the elimination of invading pathogens including Mycobacterium tuberculosis (Mtb). As a consequence, Mtb has evolved different strategies to hi
Externí odkaz:
https://doaj.org/article/fe31d479545c4217b1e5c8195af409a8