Production of IgG antibodies to pneumococcal polysaccharides is associated with expansion of ICOS+ circulating memory T follicular-helper cells which is impaired by HIV infection.

Autor: Laila N Abudulai, Sonia Fernandez, Karli Corscadden, Sally A Burrows, Michael Hunter, M Christian Tjiam, Lea-Ann S Kirkham, Jeffrey J Post, Martyn A French

Publikováno v: PLoS ONE, Vol 12, Iss 5, p e0176641 (2017)

Dysfunction of T follicular-helper (TFH) cells is a possible cause of impaired germinal centre (GC) and IgG antibody responses in individuals with human immunodeficiency virus-1 (HIV-1) infection and might contribute to decreased magnitude and isotyp

Externí odkaz: https://doaj.org/article/a91e74ee77684e81b9f7fec1a94d0cb3

Klebsiella aerogenes Adhesion Behaviour during Biofilm Formation on Monazite

Autor: Arya Van Alin, Melissa K. Corbett, Homayoun Fathollahzadeh, M. Christian Tjiam, Andrew Putnis, Jacques Eksteen, Anna H. Kaksonen, Elizabeth Watkin

Publikováno v: Microorganisms, Vol 11, Iss 5, p 1331 (2023)

The adsorption behaviour of micro-organisms during the initial attachment stage of biofilm formation affects subsequent stages. The available area for attachment and the chemophysical properties of a surface affect microbial attachment performance. T

Externí odkaz: https://doaj.org/article/1a1cb94c6fb14f14b070605eea648a43

Single-nucleus RNA sequencing of pre-malignant liver reveals disease-associated hepatocyte state with HCC prognostic potential

Autor: Rodrigo Carlessi, Elena Denisenko, Ebru Boslem, Julia Köhn-Gaone, Nathan Main, N. Dianah B. Abu Bakar, Gayatri D. Shirolkar, Matthew Jones, Aaron B. Beasley, Daniel Poppe, Benjamin J. Dwyer, Connie Jackaman, M. Christian Tjiam, Ryan Lister, Michael Karin, Jonathan A. Fallowfield, Timothy J. Kendall, Stuart J. Forbes, Elin S. Gray, John K. Olynyk, George Yeoh, Alistair R.R. Forrest, Grant A. Ramm, Mark A. Febbraio, Janina E.E. Tirnitz-Parker

Publikováno v: Carlessi, R, Denisenko, E, Boslem, E, Köhn-Gaone, J, Main, N, Abu bakar, N D B, Shirolkar, G D, Jones, M, Beasley, A B, Poppe, D, Dwyer, B J, Jackaman, C, Tjiam, M C, Lister, R, Karin, M, Fallowfield, J A, Kendall, T J, Forbes, S J, Gray, E S, Olynyk, J K, Yeoh, G, Forrest, A R R, Ramm, G A, Febbraio, M A & Tirnitz-Parker, J E E 2023, ' Single-nucleus RNA sequencing of pre-malignant liver reveals disease-associated hepatocyte state with HCC prognostic potential ', Cell Genomics, pp. 100301 . https://doi.org/10.1016/j.xgen.2023.100301

Current approaches to stage chronic liver diseases have limited utility to predict liver cancer risk. Here, we employed single nucleus RNA sequencing (snRNA-seq) to characterize the cellular microenvironment of healthy and pre-malignant livers using

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d79b1e0fbed62d67780b4f1bbfca2265
https://doi.org/10.1016/j.xgen.2023.100301

Control of early HIV-1 infection associates with plasmacytoid dendritic cell-reactive opsonophagocytic IgG antibodies to HIV-1 p24

Autor: M. Christian Tjiam, Jesse D. Armitage, Sonia Fernandez, Martyn A. French, James P. A. Taylor, Dino B.A. Tan, Lucy Sariputra, Anthony D. Kelleher, Silvia Lee

Publikováno v: AIDS. 30:2757-2765

We have previously demonstrated that HIV-1 p24-specific plasmacytoid dendritic cell-reactive opsonophagocytic antibody (PROAb) responses associate with control of chronic HIV infection. Here, we examined whether HIV-1 p24-specific PROAbs associate wi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::77930159507c1bc3759a5ad1a5ca219d
https://doi.org/10.1097/qad.0000000000001242

The association of HIV-1 Gag-specific IgG antibodies with natural control of HIV-1 infection in individuals not carrying HLA-B*57:01 is only observed in viremic controllers

Autor: Martyn A. French, Jeffrey N. Martin, Sonia Fernandez, Dino B.A. Tan, Lucy Sariputra, Steven G. Deeks, Silvia Lee, M. Christian Tjiam, Mazmah A. Morshidi

To expand upon our previous observation that HIV-1 Gag-specific IgG antibodies were highest in HIV controllers not carrying HLA-B*57:01, we analysed these antibodies in a larger cohort of viremic controllers (VCs) or elite controllers (ECs) consideri

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8846c548fd6c450463417e82cb7fc6dd
https://europepmc.org/articles/PMC5634911/