Zobrazeno 1 - 10
of 5 286
pro vyhledávání: '"M Charles"'
Autor:
Lingchao Ji, Beatriz C Borges, David T Martel, Calvin Wu, M Charles Liberman, Susan E Shore, Gabriel Corfas
Publikováno v:
PLoS Biology, Vol 22, Iss 6, p e3002665 (2024)
Loss of synapses between spiral ganglion neurons and inner hair cells (IHC synaptopathy) leads to an auditory neuropathy called hidden hearing loss (HHL) characterized by normal auditory thresholds but reduced amplitude of sound-evoked auditory poten
Externí odkaz:
https://doaj.org/article/987d6425caee416eb4dc1a221b0659cb
Autor:
M Charles Liberman
Publikováno v:
F1000Research, Vol 6 (2017)
The classic view of sensorineural hearing loss has been that the primary damage targets are hair cells and that auditory nerve loss is typically secondary to hair cell degeneration. Recent work has challenged that view. In noise-induced hearing loss,
Externí odkaz:
https://doaj.org/article/42ecd1dbfcf641708b2309030377805e
Publikováno v:
PLoS ONE, Vol 11, Iss 9, p e0162726 (2016)
Recent work suggests that hair cells are not the most vulnerable elements in the inner ear; rather, it is the synapses between hair cells and cochlear nerve terminals that degenerate first in the aging or noise-exposed ear. This primary neural degene
Externí odkaz:
https://doaj.org/article/91f4caff8cf142e4b93d118fb0e78273
Autor:
Jane Bjerg Jensen, Andrew C Lysaght, M Charles Liberman, Klaus Qvortrup, Konstantina M Stankovic
Publikováno v:
PLoS ONE, Vol 10, Iss 5, p e0125160 (2015)
Moderate acoustic overexposure in adult rodents is known to cause acute loss of synapses on sensory inner hair cells (IHCs) and delayed degeneration of the auditory nerve, despite the completely reversible temporary threshold shift (TTS) and morpholo
Externí odkaz:
https://doaj.org/article/07b680128c0542c2a9d6a13b857dcdee
Publikováno v:
PLoS ONE, Vol 10, Iss 11, p e0142341 (2015)
Synapses between cochlear nerve terminals and hair cells are the most vulnerable elements in the inner ear in both noise-induced and age-related hearing loss, and this neuropathy is exacerbated in the absence of efferent feedback from the olivocochle
Externí odkaz:
https://doaj.org/article/7a6780addd584fbfafd124d0592fe255
Publikováno v:
eLife, Vol 3 (2014)
Neurotrophin-3 (Ntf3) and brain derived neurotrophic factor (Bdnf) are critical for sensory neuron survival and establishment of neuronal projections to sensory epithelia in the embryonic inner ear, but their postnatal functions remain poorly underst
Externí odkaz:
https://doaj.org/article/958aab6e4d6247a79bc257ae6432a7b3
Autor:
Jun Yang, Xiaoqing Liu, Yun Zhao, Michael Adamian, Basil Pawlyk, Xun Sun, D Randy McMillan, M Charles Liberman, Tiansen Li
Publikováno v:
PLoS Genetics, Vol 6, Iss 5, p e1000955 (2010)
Mutations in whirlin cause either Usher syndrome type II (USH2), a deafness-blindness disorder, or nonsyndromic deafness. The molecular basis for the variable disease expression is unknown. We show here that only the whirlin long isoform, distinct fr
Externí odkaz:
https://doaj.org/article/d40cc87784f94e8599249d143577c1d0
Publikováno v:
In Physica B: Condensed Matter 15 June 2024 683
Autor:
O'Malley, Jennifer T., Wu, Pei-zhe, Kaur, Charanjeet, Gantz, Bruce J., Hansen, Marlan R., Quesnel, Alicia M., Liberman, M. Charles
Publikováno v:
In Hearing Research June 2024 447