Zobrazeno 1 - 9
of 9
pro vyhledávání: '"M Can, Gulersonmez"'
Autor:
Marlies C. Ludikhuize, Sira Gevers, Nguyen T. B. Nguyen, Maaike Meerlo, S. Khadijeh Shafiei Roudbari, M. Can Gulersonmez, Edwin C. A. Stigter, Jarno Drost, Hans Clevers, Boudewijn M. T. Burgering, Maria J. Rodríguez Colman
Publikováno v:
Communications Biology, Vol 5, Iss 1, Pp 1-16 (2022)
In p53-deficient colorectal cancer organoids, 5-fluorouracil induces pyrimidine imbalance, which causes DNA damage and cell death. Rewiring glucose metabolism through PDK inhibition by DCA enhances 5-FU toxicity in glycolytic p53-deficient organoids.
Externí odkaz:
https://doaj.org/article/c8a2e24e3c664ab7b22d3021e93d4b64
Autor:
Koos de Wit, Ulrich Beuers, Anna Mukha, Edwin C. A. Stigter, M. Can Gulersonmez, Jose M. Ramos Pittol, Sabine Middendorp, R. Bart Takkenberg, Saskia W. C. van Mil
Publikováno v:
Liver International. 43
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2e70f0bdbff19ca8cbb296047f09d893
https://doi.org/10.1111/liv.15543
https://doi.org/10.1111/liv.15543
Autor:
Marlies C. Ludikhuize, Sira Gevers, Nguyen T. B. Nguyen, Maaike Meerlo, S. Khadijeh Shafiei Roudbari, M. Can Gulersonmez, Edwin C. A. Stigter, Jarno Drost, Hans Clevers, Boudewijn M. T. Burgering, Maria J. Rodríguez Colman
Publikováno v:
Communications Biology, 5(1). Nature Research
Despite the fact that 5-fluorouracil (5-FU) is the backbone for chemotherapy in colorectal cancer (CRC), the response rates in patients is limited to 50%. The mechanisms underlying 5-FU toxicity are debated, limiting the development of strategies to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fe4c6e385e7fdeaa49121f97775fe202
https://pure.knaw.nl/portal/en/publications/cd17bb28-70e5-4147-9b15-94394daf0df3
https://pure.knaw.nl/portal/en/publications/cd17bb28-70e5-4147-9b15-94394daf0df3
Autor:
Marlies Ludikhuize, Sira Gevers, Nguyen Nguyen, Maaike Meerlo, S. Khadijeh Shafiei Roudbari, M. Can Gulersonmez, Edwin Stigter, Jarno Drost, Hans Clevers, Boudewijn Burgering, Maria Rodríguez Colman
5-fluorouracil (5-FU) is the backbone for chemotherapy in colorectal cancer (CRC), however response rates in patients are limited to 50%. Unexpectedly, the molecular mechanisms by which 5-FU ultimately induces toxicity remain debated, limiting the de
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2b473c13f15b7a7f6117bf5b784439ef
https://doi.org/10.21203/rs.3.rs-1054076/v1
https://doi.org/10.21203/rs.3.rs-1054076/v1
Autor:
Marlies C, Ludikhuize, Sira, Gevers, Nguyen T B, Nguyen, Maaike, Meerlo, S Khadijeh Shafiei, Roudbari, M Can, Gulersonmez, Edwin C A, Stigter, Jarno, Drost, Hans, Clevers, Boudewijn M T, Burgering, Maria J, Rodríguez Colman
Publikováno v:
Communications biology. 5(1)
Despite the fact that 5-fluorouracil (5-FU) is the backbone for chemotherapy in colorectal cancer (CRC), the response rates in patients is limited to 50%. The mechanisms underlying 5-FU toxicity are debated, limiting the development of strategies to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::f3979969f46d2d108887abde4150a538
https://pubmed.ncbi.nlm.nih.gov/36316440
https://pubmed.ncbi.nlm.nih.gov/36316440
Autor:
Mathew J. Garnett, Else Driehuis, Arne Van Hoeck, Johan H. van Es, Hayley E. Francies, Lodewijk A.A. Brosens, Veerle Geurts, Robert P. de Vries, Sigrid Kolders, Lodewyk F. A. Wessels, Boudewijn M.T. Burgering, Kat Moore, Gergana Bounova, Sylvia F. Boj, Folkert H.M. Morsink, Edwin C. A. Stigter, Hans Clevers, Edwin Cuppen, G. Johan A. Offerhaus, Onno Kranenburg, M. Can Gulersonmez, Ana Gracanin
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America. National Academy of Sciences
Proc Natl Acad Sci U S A
Proc Natl Acad Sci U S A
We report the derivation of 30 patient-derived organoid lines (PDOs) from tumors arising in the pancreas and distal bile duct. PDOs recapitulate tumor histology and contain genetic alterations typical of pancreatic cancer. In vitro testing of a panel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cdec23c70add841eb5de1cc9e19bb429
https://pure.knaw.nl/portal/en/publications/4db45fba-cb9b-4424-af43-7e2cd39f18e4
https://pure.knaw.nl/portal/en/publications/4db45fba-cb9b-4424-af43-7e2cd39f18e4
Autor:
Thomas Hankemeier, Stephan Michel, Michel van Weeghel, Jos H. T. Rohling, Johanna H. Meijer, M. Can Gulersonmez, M. Renate Buijink, Amy C. Harms
Publikováno v:
Metabolomics, 14(10)
Metabolomics
Metabolomics, 14, 122
Metabolomics
Metabolomics, 14, 122
Introduction Most organisms display circadian rhythms in physiology and behaviour. In mammals, these rhythms are orchestrated by the suprachiasmatic nucleus (SCN). Recently, several metabolites have emerged as important regulators of circadian timeke
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5de6b318a7553f74f7e97b7a886f5fd0
https://pubmed.ncbi.nlm.nih.gov/30830420
https://pubmed.ncbi.nlm.nih.gov/30830420
Sheathless Capillary Electrophoresis–Mass Spectrometry for Metabolic Profiling of Biological Samples
Publikováno v:
Journal of Visualized Experiments.
In metabolomics, a wide range of analytical techniques is used for the global profiling of (endogenous) metabolites in complex samples. In this paper, a protocol is presented for the analysis of anionic and cationic metabolites in biological samples
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0b8462c306418deb1bd55af5f879f51a
https://doi.org/10.3791/54535
https://doi.org/10.3791/54535
Autor:
Koos de Wit, Ulrich Beuers, Anna Mukha, Edwin C. A. Stigter, M. Can Gulersonmez, Jose M. Ramos Pittol, Sabine Middendorp, R. Bart Takkenberg, Saskia W. C. van Mil
Publikováno v:
Liver international. Wiley-Blackwell
BACKGROUND AND AIMS: Recurrent hepatic encephalopathy (HE) is characterized by hyperammonemia in combination with neuropsychiatric abnormalities and is treated with lactulose and rifaximin. Rifaximin is a Pregnane X Receptor (PXR) agonist with low sy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fe500db14f9fd4103f3bfada8bb079a7