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Bioavailability and relative tissue distribution of [125I]‐recombinant human thrombin following intravenous or subcutaneous administration to non‐human primates

Autor: Kenneth B. Lewis, Jennifer Visich, M. C. Rogge, B. Meengs, K. A. Byrnes-Blake

Publikováno v: Journal of Thrombosis and Haemostasis. 4:1962-1968

Summary. Background: Recombinant human thrombin (rhThrombin) is being developed as a general adjunct to hemostasis. Endogenous thrombin is rapidly inactivated by complex formation with antithrombin III and other inhibitors. It follows that these inhi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2a6b138688dff1261fad595b0b1d22fc
https://doi.org/10.1111/j.1538-7836.2006.02097.x

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Absence of a pharmacokinetic interaction between digoxin and levofloxacin

Autor: J Natarajan, M C Rogge, S C Chien, A T Chow, F Wong, R R Williams

Publikováno v: Journal of Clinical Pharmacy and Therapeutics. 27:7-12

Background: Levofloxacin, a broad-spectrum fluoroquinolone, may enhance digoxin bioavailability by eliminating intestinal flora that metabolize digoxin. Moreover, levofloxacin, which is eliminated primarily by glomerular filtration and active tubular

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bac8042aefd0600b630a6e29337bc6bd
https://doi.org/10.1046/j.1365-2710.2002.00388.x

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[Untitled]

Autor: George R. Pickett, P. Skyba, A. M. Guénault, M. C. Rogge, M. Bartkowiak, Shaun N. Fisher, Richard P. Haley

Publikováno v: Journal of Low Temperature Physics. 126:533-538

We have measured the A-B boundary wall contact angle and the phase interface surface tension in superfluid He-3. The measurements have been made in the ballistic temperature regime at zero pressure in magnetic fields up to 400 mT. We infer the surfac

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::de9cab3df887d1440a94461e6bb5fb53
https://doi.org/10.1023/a:1013758916085

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Spin Droplet Formation in Quantum Dots

Autor: M. C. Rogge, E. Räsänen, R. J. Haug, Jisoon Ihm, Hyeonsik Cheong

Publikováno v: AIP Conference Proceedings.

A lateral quantum dot with approx. 50 electrons is analyzed in high perpendicular magnetic fields. In a regime with two Landau levels (LL) in the quantum dot information about the spin structure is gained by investigating the position of Coulomb bloc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::0688fa3e8d75551bf4bb357164f5f6cf
https://doi.org/10.1063/1.3666373

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Enbrel (etanercept)

Autor: C A, Foerder, M C, Rogge

Publikováno v: Developments in biologicals. 109

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::d58a3302efb1493a9509de71bfdd9d7d
https://pubmed.ncbi.nlm.nih.gov/12434918

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Pharmacokinetics/dynamics of 5c8, a monoclonal antibody to CD154 (CD40 ligand) suppression of an immune response in monkeys

Autor: J V, Gobburu, C, Tenhoor, M C, Rogge, D E, Frazier, D, Thomas, C, Benjamin, D M, Hess, W J, Jusko

Publikováno v: The Journal of pharmacology and experimental therapeutics. 286(2)

The pharmacokinetics and pharmacodynamics (PK/PD) of chimeric (Ch5c8) and humanized (Hu5c8) 5c8, a monoclonal antibody that binds CD154 (CD40 ligand), thus blocking the interaction between CD40 and CD154, were investigated in cynomolgus monkeys. Sing

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::d92fef830e16f98230ef0c7a5dac4bac
https://pubmed.ncbi.nlm.nih.gov/9694951

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Pharmacokinetics and safety of oral levofloxacin in human immunodeficiency virus-infected individuals receiving concomitant zidovudine

Autor: Andrew T. Chow, S C Chien, M C Rogge, R R Williams, C W Hendrix

Publikováno v: Antimicrobial agents and chemotherapy. 41(8)

This phase I, double-blind, randomized, placebo-controlled, parallel-design study was conducted to evaluate the safety and pharmacokinetics of levofloxacin in human immunodeficiency virus (HIV)-infected subjects concomitantly receiving a stable regim

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ae12a582c697c90ed6af96926261c243
https://pubmed.ncbi.nlm.nih.gov/9257757

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Bioequivalence of oral and intravenous ofloxacin after multiple-dose administration to healthy male volunteers

Autor: M C Rogge, S C Flor, Andrew T. Chow

The bioequivalence of oral and intravenous ofloxacin was investigated after the administration of multiple doses of 400 mg every 12 h to 20 healthy male volunteers in a randomized, crossover, open-label study. Ofloxacin concentrations in plasma were

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::99042e95e946947c15c985fec7034eb3
https://europepmc.org/articles/PMC187996/

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Self-emulsifying drug delivery systems: formulation and biopharmaceutic evaluation of an investigational lipophilic compound

Autor: S A, Charman, W N, Charman, M C, Rogge, T D, Wilson, F J, Dutko, C W, Pouton

Publikováno v: Pharmaceutical research. 9(1)

Self-emulsifying drug delivery systems (SEDDSs) represent a possible alternative to traditional oral formulations of lipophilic compounds. In the present study, a lipophilic compound, WIN 54954, was formulated in a medium chain triglyceride oil/nonio

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::6e2e0491cc4af98f983f1f3f995c8b2c
https://pubmed.ncbi.nlm.nih.gov/1589415

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