Zobrazeno 1 - 10 of 36 pro vyhledávání: '"M C Malet-Martino"'
2
Measurement of total water and bound water contents in human stratum corneum by in vitro proton nuclear magnetic resonance spectroscopy
Autor: M. Riviere, A. Gournay, Véronique Gilard, M C Malet-Martino, R. Navarro, Robert Martino
Publikováno v: International Journal of Cosmetic Science. 20:117-125
The reliability of in vitro proton nuclear magnetic resonance (NMR) spectroscopy to specifically measure the water content of rehydrated human stratum corneum samples was assessed by comparison with the previously validated thermal desorption-mass sp
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d97b665557ee26f9be948fb1391b84b3
https://doi.org/10.1046/j.1467-2494.1998.171743.x
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3
The anti-cancer drug 5-fluorouracil is metabolized by the isolated perfused rat liver and in rats into highly toxic fluoroacetate
Autor: P Gires, R. Martino, M. C. Malet-Martino, M Arellano
Publikováno v: British Journal of Cancer
We report the first demonstration of the biotransformation of the anti-cancer drug 5-fluorouracil (FU) into two new metabolites, alpha-fluoro-beta-hydroxypropionic acid (FHPA) and fluoroacetate (FAC), in the isolated perfused rat liver (IPRL) and in
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1d81ea2fbc6cbfae980e909c44f479ef
https://doi.org/10.1038/bjc.1998.12
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4
Degradation Products of Cyclophosphamide Synthesis and Structural studies
Autor: Robert Martino, Ion Neda, Ulf Niemeyer, M. C. Malet-Martino, Reinhard Schmutzler, Bernhard Kutscher, Véronique Gilard, Jürgen Engel, Peter G. Jones, Axel Fischer
Publikováno v: Phosphorus, Sulfur, and Silicon and the Related Elements. 109:473-476
The degradation of cyclophosphamide in neutral or slightly acidic aqueous solution starts with an intramolecular alkylation leading to an intermediary bicyclic compound which hydrolyses immediately and exclusively to a nine-membered heterocycle. Subs
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::6aa728a10667530a9320d1fe1bcc6085
https://doi.org/10.1080/10426509608545193
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5
Synthesis of Glucuronides of Fluoropyrimidine Drugs: N- and O-Glucuronides of 5-Fluorocytosine and 5-Fluorouracil
Autor: N Chouini-Lalanne, M. C. Malet-Martino, J. P. Vialaneix, Robert Martino, S. Mansouri
Publikováno v: Nucleosides and Nucleotides. 12:331-350
The protected (4a-9a) and deprotected (4b-6b, 8b) glucuronides of 5-fluorocytosine and 5-fluorouracil were synthesized and characterized by mass spectrometry and 19F, 1H and 13C NMR. The substitution position of the sugar moiety on the pyrimidine rin
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::9211221e640020707bbcc7f05c765a21
https://doi.org/10.1080/07328319308017830
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7
Structural determination of a glucuronide conjugate of flucytosine in humans
Autor: N, Chouini-Lalanne, M C, Malet-Martino, V, Gilard, J C, Ader, R, Martino
Publikováno v: Drug metabolism and disposition: the biological fate of chemicals. 23(8)
The structure of a glucuronide metabolite of flucytosine (FC; 5-fluorocytosine), found in the urine of all patients treated with this antifungal drug, was determined. This compound is the O2-beta-glucuronide of FC. Its structure was established after
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::56b485b550f6b51eb56dc819a571b6e6
https://pubmed.ncbi.nlm.nih.gov/7493547
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8
THE TRIS FORMULATION OF FLUOROURACIL IS MORE CARDIOTOXIC THAN THE SODIUM-SALT FORMULATIONS
Autor: B Lasserre, M. C. Malet-Martino, R. Martino, Laurent Lemaire, M Deforni
Publikováno v: Oncology Reports
Oncology Reports, Spandidos Publications, 1994, 1 (1), pp.173-4. ⟨10.3892/or.1.1.173⟩
ResearcherID
Oncology Reports, 1994, 1 (1), pp.173-4. ⟨10.3892/or.1.1.173⟩
International audience; The cardiotoxicity of 5-fluorouracil (FU) was attributed to degradation compounds present in the injected vials, fluoroacetaldehyde (Facet) and fluoromalonaldehydic acid (FMald). FU-NaOH vials were much less cardiotoxic than F
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e23ef887408d3ab3dc6f890e38523444
https://hal.univ-angers.fr/hal-02374762
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9
Determination of the urinary excretion of ifosfamide and its phosphorated metabolites by phosphorus-31 nuclear magnetic resonance spectroscopy
Autor: Robert Martino, M. de Forni, Ulf Niemeyer, Véronique Gilard, M C Malet-Martino, J. C. Ader
Publikováno v: Cancer chemotherapy and pharmacology. 31(5)
Phosphorus-31 nuclear magnetic resonance spectroscopy was used to analyze urine samples obtained from patients treated with ifosfamide (IF). This technique allows the individual assay of all phosphorated metabolites of IF in a single analysis without
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::71b13d014ca3f8a0ad1d7cd40a3a1a06
https://pubmed.ncbi.nlm.nih.gov/8431973
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10
Cardiotoxicity of commercial 5-fluorouracil vials stems from the alkaline hydrolysis of this drug
Autor: R. Martino, Laurent Lemaire, M. de Forni, M. C. Malet-Martino, B Lasserre
Publikováno v: British Journal of Cancer
British Journal of Cancer, Cancer Research UK, 1992, 66 (1), pp.119-127. ⟨10.1038/bjc.1992.227⟩
British Journal of Cancer, 1992, 66 (1), pp.119-127. ⟨10.1038/bjc.1992.227⟩
International audience; The cardiotoxicity of 5-fluorouracil (FU) was attributed to impurities present in the injected vials. One of these impurities was identified as fluoroacetaldehyde which is metabolised by isolated perfused rabbit hearts into fl
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c9222b40247b462e8a46057f90230b3f
https://hal.univ-angers.fr/hal-02374741
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