Zobrazeno 1 - 10
of 27
pro vyhledávání: '"M C Lorence"'
Autor:
Edward W. Gregg, Sara Caldwell, Elizabeth Grimes, C. Alexander Valencia, Madhuri Hegde, Cristina da Silva, Agnieszka M. Lichanska, Brian Weslowski, Anjan Purkayastha, Devin Rhodenizer, Marina Espirages, Leah M. Morris, Clark Tibbetts, Lisa A. Borsuk, M C Lorence, Alice K. Tanner
Publikováno v:
The Journal of Molecular Diagnostics. 16:350-360
Identifying individuals as carriers of severe disease traits enables informed decision making about reproductive options. Although carrier screening has traditionally been based on ethnicity, the increasing ethnic admixture in the general population
Autor:
David Metzgar, Lisa A. Borsuk, Mohamadou Sene, Joseph Campos, Clark Tibbetts, Patrick J. Blair, Leah M. Morris, Agnieszka M. Lichanska, M C Lorence, Klaus Schäfer, Jason L. Brown, Dennis J. Faix, Christopher A. Myers, Brian Weslowski
Publikováno v:
SPIE Proceedings.
High-density resequencing microarrays support simultaneous detection and identification of multiple viral and bacterial pathogens. Because detection and identification using RPM is based upon multiple specimen-specific target pathogen gene sequences
Autor:
J. Geisselsoder, Sandra E. Graham-Lorence, M C Lorence, F. Witney, C. Carmona, Jui-Yun Lu, Julian A. Peterson
Publikováno v:
Journal of Biological Chemistry. 267:14193-14203
Cytochromes P-450 are extremely important in the oxidative metabolism of a variety of endogenous and exogenous compounds in pro- and eukaryotic organisms. Progress in understanding the structure and mechanism of action of this superfamily of enzymes
Autor:
John M. Trant, M C Lorence, Serdia O. Mack, Barbara A. Murry, Danielle Naville, J. Ian Mason, Sandra E. Graham-Lorence
Publikováno v:
Molecular and Cellular Endocrinology. 80:21-31
The isolation, cloning and expression of a DNA insert complementary to mRNA encoding rat testis 3 beta-hydroxysteroid dehydrogenase/delta 5----4-isomerase (3 beta-HSD) is reported. The insert contains an open reading frame encoding a protein of 373 a
Publikováno v:
Scopus-Elsevier
The conversion of androgens to estrogens is catalyzed by an enzyme complex named aromatase, which consists of a form of cytochrome P-450, aromatase cytochrome P-450 (cytochrome P-450AROM), and the flavoprotein, NADPH-cytochrome P-450 reductase. As a
Publikováno v:
Molecular and Cellular Endocrinology. 74:R11-R17
The rat H540 Leydig tumor cell is established as a model for acute lutropin action on the initial step of steroidogenesis, namely the conversion of cholesterol to pregnenolone. Herein, we demonstrate that H540 cells express high levels of three stero
Publikováno v:
Proceedings of the National Academy of Sciences. 87:9756-9760
Cytochrome P450IIC5 (rabbit liver 21-hydroxylase) is unusual among hepatic forms of cytochromes P450 because it catalyzes the conversion of one active steroid hormone (progesterone) to another active hormone (deoxycorticosterone). Another interesting
Publikováno v:
Endocrinology. 126:2493-2498
The isolation, cloning, and expression of a cDNA insert complementary to mRNA encoding human 3 beta-hydroxysteroid dehydrogenase/delta 5----4isomerase is reported. The insert contains an open reading frame encoding a protein of 372 amino acids, the i
Publikováno v:
Journal of Biological Chemistry. 265:6066-6073
The oxidation of camphor by cytochrome P-450cam requires the participation of a flavoprotein, putidaredoxin reductase, and an iron-sulfur protein, putidaredoxin, to mediate the transfer of electrons from NADH to P-450 for oxygen activation. A 2.2-kil
Autor:
J. Ian Mason, Sandra E. Graham-Lorence, M C Lorence, Alan J Conley, Donita Sanders, Masaaki Kagimoto, Barbara A. Murry, Kunihiko Oka
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression. 1130:75-77
We describe the isolation and characterization of a cDNA encoding the complete porcine neonatal testis 17 alpha-hydroxylase/C-17,20-lyase cytochrome P-450. The deduced amino acid sequence is 509 amino acids in length.