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Myeloid Dendritic Cells Are Enriched in Lymph Node Tissue of Early Rheumatoid Arthritis Patients but not in At Risk Individuals

Autor: KI Maijer, K.P. van Lienden, M I Ramos, L G M van Baarsen, Paul P. Tak, M C Lebre, TH Ramwadhdoebe, M. Maas, Danielle M. Gerlag

Publikováno v: Cells, Vol 8, Iss 7, p 756 (2019)
Cells, 8(7). MDPI Multidisciplinary Digital Publishing Institute
Cells
Volume 8
Issue 7

Lymph nodes (LNs) are highly organized structures where specific immune responses are initiated by dendritic cells (DCs). We investigated the frequency and distribution of human myeloid (mDCs) and plasmacytoid (pDCs) in LNs and blood during the earli

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dbf9237808cd331e094359ed29d60c5c
https://www.mdpi.com/2073-4409/8/7/756

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Synovial IL-21/TNF-producing CD4(+) T cells induce joint destruction in rheumatoid arthritis by inducing matrix metalloproteinase production by fibroblast-like synoviocytes

Autor: Saida Aarrass, Boy Helder, Pedro L Vieira, Paul P. Tak, M C Lebre, Thomas Newsom-Davis, Man Wai Tang, Gavin R. Screaton

Publikováno v: Journal of leukocyte biology, 101(3), 775-783. FASEB

Bone and cartilage destruction is one of the key manifestations of rheumatoid arthritis (RA). Although the role of T helper (Th)17 cells in these processes is clear, the role of IL-21–producing cells T cells has been neglected. We sought to investi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::297a49330fd0bd618d3c5afebe1b4ab4
https://pure.amc.nl/en/publications/synovial-il21tnfproducing-cd4-t-cells-induce-joint-destruction-in-rheumatoid-arthritis-by-inducing-matrix-metalloproteinase-production-by-fibroblastlike-synoviocytes(d1bd9548-8f27-498b-a444-4291f69f3b35).html

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Fms-like tyrosine kinase 3 ligand-dependent dendritic cells in autoimmune inflammation

Autor: M I Ramos, PP Tak, M C Lebre

Publikováno v: Autoimmunity reviews. 13(2):117-124

Dendritic cells (DCs) are specialized in capture, processing and presentation of antigens to T cells. Depending on the type of DC and its activation state, the interaction of DCs with naive T cells can lead to different types of immune response, or t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c5b02ebc513053bf063461f73e2bfd63
https://doi.org/10.1016/j.autrev.2013.09.010

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MICE LACKING FLT3L ARE PROTECTED FROM COLLAGEN-INDUCED ARTHRITIS: IMPAIRED T CELL FUNCTION?

Autor: M C Lebre, Saida Aarrass, M I Ramos, Olga N. Karpus, PP Tak, Sten Eirik W. Jacobsen

Backgroundand objectives Autoimmune diseases often result from inappropriate or unregulated activation of autoreactive T cells. The induction and maintenance of T cell tolerance to tissue antigens is essential to prevent autoimmunity. Combinations of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dba15776e24652272218cfe1c4aa3c8e
https://doi.org/10.1136/annrheumdis-2011-201234.12

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Absence of Fms-like tyrosine kinase 3 ligand (Flt3L) signalling protects against collagen-induced arthritis

Autor: M C Lebre, Saida Aarrass, Olga N. Karpus, M I Ramos, Sten Eirik W. Jacobsen, Paul P. Tak, P. Broekstra

Publikováno v: Annals of the rheumatic diseases, 74(1), 211-219. BMJ Publishing Group

ObjectiveComprehending the mechanisms that regulate activation of autoreactive T cells and B cell antibody production is fundamental for understanding the breakdown in self-tolerance and development of autoimmunity. Here we studied the role of Fms-li

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7ef0afd6fe3e35b2dacaf971f79e47b2
https://ora.ox.ac.uk/objects/uuid:9df6562d-11e0-4e8e-8b94-e967595046ee

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Macrophage Subsets in Immune-Mediated Inflammatory Disease: Lessons from Rheumatoid Arthritis, Spondyloarthritis, Osteoarthitis, Behets Disease and Gout

Autor: Paul P. Tak, M C Lebre

Publikováno v: The Open Arthritis Journal. 3:18-23

Macrophages are a major cell population in most of the tissues, and their numbers increase massively in in- flammation, in wound healing and in tumors. In particular, macrophages contribute to autoimmune events in rheumatic diseases, such as rheumato

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::391a6f33456ff985b22bd59355a01852
https://doi.org/10.2174/1876539401003010018

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Stimulation of nicotinic acetylcholine receptors attenuates collagen-induced arthritis in mice

Autor: Daniel Elbaum, Marjolein A. van Maanen, Paul P. Tak, Margriet J. Vervoordeldonk, M C Lebre, Tom van der Poll, Gregory J. LaRosa

Publikováno v: Arthritis and rheumatism, 60(1), 114-122. John Wiley and Sons Inc.

Objective The parasympathetic nervous system, through the vagus nerve, can down-regulate inflammation in vivo by decreasing the release of cytokines, including tumor necrosis factor α (TNFα), by activated macrophages. The vagus nerve may exert anti

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::767abce2fa7ad2be80dfaaa3626af216
https://doi.org/10.1002/art.24177

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Reduced CLEC9A expression in synovial tissue of psoriatic arthritis patients after adalimumab therapy

Autor: Maria J. H. de Hair, Boy Helder, Arno W R van Kuijk, M I Ramos, Danielle M. Gerlag, Marcel B. M. Teunissen, M C Lebre, Saida Aarrass, Paul P. Tak

Publikováno v: Rheumatology (Oxford, England), 55(9), 1575-1584. Oxford University Press

We aimed to investigate the early changes in expression of C-type lectin domain family 9, member A (CLEC9A), a C-type lectin that is specifically expressed by the CD141(+) dendritic cell subset that is involved in cross-presentation to CD8(+) T cells

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0fdb6bf062314ace71e858ba129825f7
https://pubmed.ncbi.nlm.nih.gov/27179104

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Anti-TNF therapy reduces serum levels of chemerin in rheumatoid arthritis: a new mechanism by which anti-TNF might reduce inflammation

Autor: Ana S. F. Oliveira, Paul P. Tak, M C Lebre, Carla A. Wijbrandts, Danielle M. Gerlag, M M J Herenius

Publikováno v: PLoS ONE, Vol 8, Iss 2, p e57802 (2013)
PLoS ONE
PLoS ONE, 8(2). Public Library of Science

Background Chemerin is a specific chemoattractant for macrophages and dendritic cells (DC). In addition, it can rapidly stimulate macrophage adhesion to extracellular matrix proteins and adhesion molecules and is able to activate fibroblast-like syno

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::082be767bc42b990fb72d4330735bffc
https://doi.org/10.1371/journal.pone.0057802

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