Zobrazeno 1 - 10
of 243
pro vyhledávání: '"M C Janssen"'
Autor:
Bert van de Kooij, Evert de Vries, Rogier W. Rooswinkel, George M. C. Janssen, Frédérique K. Kok, Peter A. van Veelen, Jannie Borst
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-13 (2023)
Abstract The majority of proteins in mammalian cells are modified by covalent attachment of an acetyl-group to the N-terminus (Nt-acetylation). Paradoxically, Nt-acetylation has been suggested to inhibit as well as to promote substrate degradation. C
Externí odkaz:
https://doaj.org/article/304e7d80f3b147c9966b6c141fbfb7bc
Publikováno v:
SciPost Physics, Vol 15, Iss 5, p 217 (2023)
The mode-coupling theory of the glass transition (MCT) has been at the forefront of fundamental glass research for decades, yet the theory's underlying approximations remain obscure. Here we quantify and critically assess the effect of each MCT appro
Externí odkaz:
https://doaj.org/article/d1e7e062f2f544e4834a80d4ce313bfb
Publikováno v:
Physical Review Research, Vol 4, Iss 4, p L042033 (2022)
Active matter studies are increasingly geared towards the high-density or glassy limit. This is mainly inspired by the remarkable resemblance between active glassy materials and conventional passive glassy matter. Interestingly, within this limit it
Externí odkaz:
https://doaj.org/article/d55b88c099e54f818a602d6e9bd5d1ed
Publikováno v:
Physical Review Research, Vol 5, Iss 3, p 033121 (2023)
We perform a systematic analysis of continuously polydisperse hard-sphere fluids as a function of the degree of polydispersity within the framework of the mode-coupling theory of the glass transition (MCT). Our results show that a high degree of poly
Externí odkaz:
https://doaj.org/article/b4b5b7246f244ded870a02f77998509f
Publikováno v:
Physical Review Research, Vol 5, Iss 3, p 033120 (2023)
State-of-the-art techniques for simulating deeply supercooled liquids require a high degree of size polydispersity to be effective. While these techniques have enabled great insight into the microscopic dynamics near the glass transition, the effect
Externí odkaz:
https://doaj.org/article/d41654836b2d48c09d4e76cc4535ac92
Autor:
Kyra van der Pan, Sara Kassem, Indu Khatri, Arnoud H. de Ru, George M. C. Janssen, Rayman T. N. Tjokrodirijo, Fadi al Makindji, Eftychia Stavrakaki, Anniek L. de Jager, Brigitta A. E. Naber, Inge F. de Laat, Alesha Louis, Wouter B. L. van den Bossche, Lisette B. Vogelezang, Rutger K. Balvers, Martine L. M. Lamfers, Peter A. van Veelen, Alberto Orfao, Jacques J. M. van Dongen, Cristina Teodosio, Paula Díez
Publikováno v:
Frontiers in Medicine, Vol 9 (2022)
Mass spectrometry (MS)-based proteomics profiling has undoubtedly increased the knowledge about cellular processes and functions. However, its applicability for paucicellular sample analyses is currently limited. Although new approaches have been dev
Externí odkaz:
https://doaj.org/article/10dcef007c494cce97c498dc3e5d7653
Autor:
Leonie Kollenstart, Sophie C. van der Horst, Kees Vreeken, George M. C. Janssen, Fabrizio Martino, Hanneke Vlaming, Peter A. van Veelen, Fred van Leeuwen, Haico van Attikum
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-17 (2021)
Abstract The collection of known posttranslational modifications (PTMs) has expanded rapidly with the identification of various non-acetyl histone lysine acylations, such as crotonylation, succinylation and butyrylation, yet their regulation is still
Externí odkaz:
https://doaj.org/article/49d63814a9b84605a12502b41eee17ad
Autor:
Giulia Janzen, Liesbeth M. C. Janssen
Publikováno v:
Physical Review Research, Vol 4, Iss 1, p L012038 (2022)
It is well established that glassy materials can undergo out-of-equilibrium aging, i.e., their properties gradually change over time. There is rapidly growing evidence that dense active and living systems also exhibit many features of glassy behavior
Externí odkaz:
https://doaj.org/article/b1189e3cc0b246bc87620001fac5dfa7
Autor:
Simone Ciarella, Massimiliano Chiappini, Emanuele Boattini, Marjolein Dijkstra, Liesbeth M C Janssen
Publikováno v:
Machine Learning: Science and Technology, Vol 4, Iss 2, p 025010 (2023)
We introduce a machine-learning approach to predict the complex non-Markovian dynamics of supercooled liquids from static averaged quantities. Compared to techniques based on particle propensity, our method is built upon a theoretical framework that
Externí odkaz:
https://doaj.org/article/ef5c796db2bf402780f66b5640baaa0b
Autor:
Wouter J. Venema, Sanne Hiddingh, Joke H. de Boer, Frans H. J. Claas, Arend Mulder, Anneke I. den Hollander, Efstratios Stratikos, Siranush Sarkizova, Lars T. van der Veken, George M. C. Janssen, Peter A. van Veelen, Jonas J. W. Kuiper
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
Birdshot Uveitis (BU) is a blinding inflammatory eye condition that only affects HLA-A29-positive individuals. Genetic association studies linked ERAP2 with BU, an aminopeptidase which trims peptides before their presentation by HLA class I at the ce
Externí odkaz:
https://doaj.org/article/96774bd91fe94255b5f0907aab6bb0ce