Performance metrics for models designed to predict treatment effect

Autor: C. C. H. M. Maas, D. M. Kent, M. C. Hughes, R. Dekker, H. F. Lingsma, D. van Klaveren

Publikováno v: BMC Medical Research Methodology, Vol 23, Iss 1, Pp 1-12 (2023)

Abstract Background Measuring the performance of models that predict individualized treatment effect is challenging because the outcomes of two alternative treatments are inherently unobservable in one patient. The C-for-benefit was proposed to measu

Externí odkaz: https://doaj.org/article/23accaec1591486fa6a6c1a76cdab252

Does blood flow limit acute hypoxia performance in larval zebrafish (Danio rerio)?

Autor: M C Hughes, Steve F. Perry

Publikováno v: Journal of Comparative Physiology B. 191:469-478

Oxygen uptake (ṀO2) in larval zebrafish prior to maturation of the gill relies on cutaneous O2 transfer. Under normoxic conditions, rates of cutaneous O2 transfer are unaffected by haemoglobin availability but are diminished in fish lacking a funct

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::ea20593ebfac1c26a8c9b9b33baf9f4e
https://doi.org/10.1007/s00360-020-01331-z

Patient age and risk of recurrence of primary melanoma at high risk of spread

Autor: Kiarash Khosrotehrani, L. A. von Schuckmann, Reza Ghiasvand, Bernard Mark Smithers, Vanessa L. Beesley, Adèle C. Green, M. C. Hughes, M. Malt

Publikováno v: The British journal of dermatologyReferences. 184(3)

Melanoma is more aggressive with poorer outcomes in older than younger patients. Older age has been associated with greater tumour thickness, higher rates of ulceration, and high mitotic rates, but it is not clear whether poorer outcomes in the elder

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e435ab0ef20bda080f72ad24bfcd4cc9
https://pubmed.ncbi.nlm.nih.gov/33053218

Forearm hair density and risk of keratinocyte cancers in Australian adults

Autor: J.C. van der Pols, Adèle C. Green, L. A. von Schuckmann, M. C. Hughes

Publikováno v: von Schuckmann, L A, Hughes, M C, Green, A C & van der Pols, J C 2016, ' Forearm hair density and risk of keratinocyte cancers in Australian adults ', Archives of Dermatological Research, vol. 308, no. 9, pp. 617-624 . https://doi.org/10.1007/s00403-016-1680-5

Evidence suggests that progenitor cells of keratinocyte cancers (basal cell carcinoma (BCC) and squamous cell carcinoma (SCC)) may originate from epidermal stem cells including hair follicle stem cells. We hypothesised that, therefore, a relatively h

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5ad2d316c3085acb1b875580aebb1125
https://pubmed.ncbi.nlm.nih.gov/27590883

Vitamin D Fortification: A Promising Approach to Overcome Drug Resistance and Tolerance in Therapeutic Interventions.

Autor: Digvijaya¹ (AUTHOR), Mittal, Saurabh² (AUTHOR), Mittal, Prateek³ (AUTHOR), Singh, Ruhi² (AUTHOR), Gupta, Simran² (AUTHOR), Singh, Taniya² (AUTHOR), Khan, Rahmuddin⁴ (AUTHOR), Alzobaidi, Nafaa⁵ (AUTHOR) nha.moqbel@pharm.adenuniv.com, Alhalmi, Abdulsalam⁶ (AUTHOR), Cherniack, Evan P. (AUTHOR)

Publikováno v: Scientifica. 11/22/2024, Vol. 2024, p1-16. 16p.