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Endostatin expression in pancreatic tissue is modulated by elastase

Autor: Simon R. Bramhall, R D Brammer, M C Eggo

Publikováno v: British Journal of Cancer

Pancreatic tumours are scirrhous, avascular tumours, suggesting that they may produce angiogenesis inhibitors that suppress the growth of the vasculature to the tumour and metastases. We have sought evidence for the angiogenesis inhibitor, endostatin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fd2b5964efb0b17bcadc6c81ddd80912
http://europepmc.org/articles/PMC2361736

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Non-steroidal anti-inflammatory drug-induced apoptosis in gastric cancer cells is blocked by protein kinase C activation through inhibition of c-myc

Autor: B C Y Wong, K C Lai, C K Ching, M C Eggo, G H Zhu, E Y T Chan, S K Lam, S T Yuen

Publikováno v: British Journal of Cancer

Apoptosis plays a major role in gastrointestinal epithelial cell turnover, ulcerogenesis and tumorigenesis. We have examined apoptosis induction by non-steroidal anti-inflammatory drugs (NSAIDs) in human gastric (AGS) cancer cells and the role of pro

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::42a2ebba07ff0ea82c74d84f11bd1151
https://doi.org/10.1038/sj.bjc.6690062

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Insulin-like growth factors and their binding proteins in human colonocytes: preferential degradation of insulin-like growth factor binding protein 2 in colonic cancers

Autor: M. J. S. Langman, M. C. Eggo, N. P. Michell

Publikováno v: British Journal of Cancer

We have compared the expression of insulin-like growth factors (IGFs) and IGF binding proteins (IGFBPs) in ten paired samples of normal and tumour colonic tissue with regard to both mRNA and protein. We have compared sensitivity of these tissues to I

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5a0d98f97908370539030fb700e9eb13
https://doi.org/10.1038/bjc.1997.337

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Insulin-like Growth Factor Binding Proteins as Mediators of IGF-I Effects on Colon Cancer Cell Proliferation

Autor: M. J. S. Langman, N. P. Michell, M. C. Eggo, S. Dent

Publikováno v: Growth Factors. 14:269-277

Human colon cancer cell lines COLO205, HT29 and SW620 are known to secrete insulin-like growth factor II (IGF-II) and its modulatory binding proteins (IGFBPs). We have characterised the sensitivity of these cell lines to exogenous IGF-I and have exam

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ea9bc9f374c6ee9a64604a270233620c
https://doi.org/10.3109/08977199709021525

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Functional human thyroid cells and their insulin-like growth factor- binding proteins: regulation by thyrotropin, cyclic 3',5' adenosine monophosphate, and growth factors

Autor: M. C. Eggo

Publikováno v: Journal of Clinical Endocrinology & Metabolism. 81:3056-3062

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::2cd8c2247e509815cb52bee1d299ef09
https://doi.org/10.1210/jc.81.8.3056

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Expression of fibroblast growth factors in thyroid cancer

Autor: M. C. Eggo

Publikováno v: Journal of Clinical Endocrinology & Metabolism. 80:1006-1011

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::73a7d9dce748739e27c8baf32424d64a
https://doi.org/10.1210/jc.80.3.1006

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Control of thyroid secretion: effects of stimulators of protein kinase C, thyrotropin, and calcium mobilization on secretion of iodinated compounds from sheep thyroid cells

Autor: M. C. Eggo

Publikováno v: Endocrinology. 130:2274-2283

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::284395c9e7f92f0daac61b2a0a958648
https://doi.org/10.1210/en.130.4.2274

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Endostatin expression in a pancreatic cell line is modulated by a TNFalpha-dependent elastase

Autor: M C Eggo, Simon R. Bramhall, R D Brammer

Publikováno v: British Journal of Cancer

Endostatin, an inhibitor of angiogenesis, is a 20 kDa fragment of the basement membrane protein, collagen XVIII. The formation of endostatin relies upon the action of proteases on collagen XVIII. TNFalpha, produced by activated macrophages, is a mult

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::68ea1ba487db9e1215418a12eb22b70d
https://pubmed.ncbi.nlm.nih.gov/16234817

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Sulphide-induced energy deficiency in colonic cells is prevented by glucose but not by butyrate

Autor: S J, Hulin, S, Singh, M A S, Chapman, A, Allan, M J S, Langman, M C, Eggo

Publikováno v: Alimentary pharmacologytherapeutics. 16(2)

In ulcerative colitis, hydrogen sulphide is postulated to impair colonocyte butyrate metabolism, leading to cellular energy deficiency and dysfunction.To determine the effects of sulphide exposure on butyrate metabolism and adenosine triphosphate lev

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::996cf3fa67fb71c8e71df6507b17f831
https://pubmed.ncbi.nlm.nih.gov/11860416

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Site-specific regulation of oestrogen receptor-alpha and -beta by oestradiol in human adipose tissue

Autor: A, Anwar, P G, McTernan, L A, Anderson, J, Askaa, C G, Moody, A H, Barnett, M C, Eggo, S, Kumar

Publikováno v: Diabetes, obesitymetabolism. 3(5)

To examine the expression of oestrogen receptors alpha and beta (ERalpha and ERbeta) and their regulation by 17beta-oestradiol (E2) in stromal cells and adipocytes from human subcutaneous (s.c.) and omental (o.m.) adipose tissue.Subcutaneous and o.m.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::334389880ab5af692919607179a1e770
https://pubmed.ncbi.nlm.nih.gov/11703424

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