Výsledky vyhledávání - "M C Dal Canto"

Autor: Patricia G. Spear, Cynthia L. Rowe, M. C. Dal Canto, Deepak Shukla

Publikováno v: Journal of Virology. 74:11773-11781

A cDNA encoding the murine homolog of human nectin-1α (also known as poliovirus receptor-related protein 1 [Prr1] and herpesvirus entry protein C [HveC]) was isolated. The protein encoded by this cDNA proved to be 95% identical in sequence to the hu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::76ca534749571e6f7ace8baade97e824
https://doi.org/10.1128/jvi.74.24.11773-11781.2000

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A low expressor line of transgenic mice carrying a mutant human Cu,Zn superoxide dismutase ( SOD1 ) gene develops pathological changes that most closely resemble those in human amyotrophic lateral sclerosis

Autor: Mark E. Gurney, M. C. Dal Canto

Publikováno v: Acta Neuropathologica. 93:537-550

About 15-20% of patients with familial amyotrophic lateral sclerosis (ALS) carry one of several missense mutations in the gene for Cu,Zn superoxide dismutase (SOD1). We have previously reported on an animal model of this disease produced by the trans

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1180c01826c62af7eca2e919c9d7c2cc
https://doi.org/10.1007/s004010050650

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Effect of Theiler's murine encephalomyelitis virus and cytokines on cultured oligodendrocytes and astrocytes

Autor: Y. Qi, M. C. Dal Canto

Publikováno v: Journal of Neuroscience Research. 45:364-374

The pathogenesis of Theiler's murine encephalomyelitis virus (TMEV)-induced demyelinating disease is still controversial. Our hypothesis is that primary infection of oligodendrocytes (OLGs) is not a crucial event in the pathogenesis of demyelination

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::b8d63dd6d0ad1febcef89a7fc7bb78b6
https://doi.org/10.1002/(sici)1097-4547(19960815)45:4<364::aid-jnr5>3.0.co

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The Golgi apparatus of spinal cord motor neurons in transgenic mice expressing mutant Cu,Zn superoxide dismutase becomes fragmented in early, preclinical stages of the disease

Autor: Zissimos Mourelatos, M E Gurney, Anna Stieber, Nicholas K. Gonatas, M. C. Dal Canto

Publikováno v: Proceedings of the National Academy of Sciences. 93:5472-5477

Dominant mutations of the SOD1 gene encoding Cu,Zn superoxide dismutase have been found in members of certain families with familial amyotrophic lateral sclerosis (ALS). To better understand the contribution of SOD1 mutations in the pathogenesis of f

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::50af31cc52a477e04803391919f4520d
https://doi.org/10.1073/pnas.93.11.5472

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Adoptively transferred CD8+ T lymphocytes provide protection against TMEV-induced demyelinating disease in BALB/c mice

Autor: S M Nicholson, M C Dal Canto, S D Miller, R W Melvold

Publikováno v: The Journal of Immunology. 156:1276-1283

On intracerebral infection with the BeAn strain of Theiler's murine encephalomyelitis virus (TMEV), certain mouse strains develop a chronic demyelinating disease similar both clinically and pathologically to human multiple sclerosis. Other strains re

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::15564549ff100af5a6e022173f39514a
https://doi.org/10.4049/jimmunol.156.3.1276

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Treatment with bacterial LPS renders genetically resistant C57BL/6 mice susceptible to Theiler's virus-induced demyelinating disease

Autor: L C Pullen, S H Park, S D Miller, M C Dal Canto, B S Kim

Publikováno v: The Journal of Immunology. 155:4497-4503

Theiler's murine encephalomyelitis virus (TMEV) induces a demyelinating disease in susceptible strains, which clinically and histopathologically resembles human multiple sclerosis. Since bacterial LPS produced by Gram-negative bacteria is known to po

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https://doi.org/10.4049/jimmunol.155.9.4497

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Inhibition of Theiler's virus-mediated demyelination by peripheral immune tolerance induction

Autor: W J Karpus, J G Pope, J D Peterson, M C Dal Canto, S D Miller

Publikováno v: The Journal of Immunology. 155:947-957

Theiler's murine encephalomyelitis virus (TMEV), a member of the cardiovirus subfamily of the Picornaviridae, is a natural pathogen of mice. Thirty to 60 days following intracerebral infection with TMEV, susceptible inbred mouse strains develop a chr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::fb7903182a8b37a2a1c593866d1ba542
https://doi.org/10.4049/jimmunol.155.2.947

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Functional evidence for epitope spreading in the relapsing pathology of experimental autoimmune encephalomyelitis

Autor: Stephen D. Miller, Carol L. Vanderlugt, Bradford L. McRae, M. C. Dal Canto

Publikováno v: The Journal of Experimental Medicine

The role of epitope spreading in the pathology of relapsing-remitting experimental autoimmune encephalomyelitis (R-EAE) was examined. Using peripherally induced immunologic tolerance as a probe to analyze the neuropathologic T cell repertoire, we sho

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https://doi.org/10.1084/jem.182.1.75

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A hybrid between a resistant and a susceptible strain of mouse alters the pattern of Theiler's murine encephalomyelitis virus-induced white matter disease and favors oligodendrocyte-mediated remyelination

Autor: M. C. Dal Canto, Roger W. Melvold, Byung S. Kim

Publikováno v: Multiple Sclerosis Journal. 1:95-103

Theiler's murine encephalomyelitis virus (TMEV) produces a chronic disease in its natural host, the mouse, characterised by primary inflammatory demyelination of the spinal cord. This viral infection is considered a very good model for human MS becau

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https://doi.org/10.1177/135245859500100207

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Mutation of a major histocompatibility class I locus, H-2D, leads to an increased virus burden and disease susceptibility in Theiler's virus-induced demyelinating disease

Autor: Stephen D. Miller, Roger D. Melvold, M. C. Dal Canto, Howard L. Lipton

Publikováno v: Journal of Neurovirology. 1:138-144

Genetic studies have demonstrated that susceptibility to Theiler's murine encephalomyelitis virus (TMEV)-induced demyelinating disease is multigenic with linkage to the MHC class I locus, H-2D. We have analyzed the effect of mutations (H-2bm13 and H-

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https://doi.org/10.3109/13550289509113960

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